Protein

MCA_05763_1

Length
1,182 amino acids

Gene name: PTP2

Description: Nuclear phosphotyrosine-specific phosphatase

Browser: contigD:2272553-2276102+

RNA-seq: read pairs 1030, FPKM 10.8, percentile rank 27.1% (100% = highest expression)

Protein function

Annotation:PTP2Nuclear phosphotyrosine-specific phosphatase
EGGNOG:0PK3PPGUG_02967phosphatase
SGD closest match:S000005734PTP2Tyrosine-protein phosphatase 2
CGD closest match:CAL0000198260PTP3Tyrosine protein phosphatase

Protein alignments

%idAln lengthE-value
MIA_03532_142.94%7291e-158MIA_03532_1
A0A0J9XG21_GEOCN42.49%4662e-103Similar to Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing OS=Geotrichum candidum GN=BN980_GECA15s02237g PE=4 SV=1
UniRef50_A0A0J9XG2142.49%4664e-100Similar to Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XG21_GEOCN
A0A161HK79_9ASCO38.44%3203e-60Tyrosine protein phosphatase PTP2 OS=Sugiyamaella lignohabitans GN=PTP2 PE=4 SV=1
A0A060T699_BLAAD37.86%3096e-55ARAD1C17886p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C17886g PE=4 SV=1
A0A1E3PPZ8_9ASCO32.14%3369e-47Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49812 PE=4 SV=1
Q6C0H6_YARLI33.58%2651e-41YALI0F24585p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F24585g PE=4 SV=1
A0A1D8PU75_CANAL29.82%3426e-34Tyrosine protein phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PTP3 PE=4 SV=1
A0A1E4TK41_9ASCO28.39%3171e-31Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_55782 PE=4 SV=1
PTP2_YEAST31.90%2329e-21Tyrosine-protein phosphatase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTP2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2182
Predicted cleavage: 14

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1182

Detailed signature matches

  1. Domain IPR001763
    Rhodanese-like domain
    1. SSF52821 (Rhodanese...)
    2. SM00450 (rhod_4)
    3. PF00581 (Rhodanese)
    4. G3DSA:3.40.25...
    5. PS50206 (RHODANESE_3)
  2. Domain IPR029021
    Protein-tyrosine phosphatase-like
    1. SSF52799 ((Phosphot...)
    2. G3DSA:3.90.19...
  3. Domain IPR003595
    Protein-tyrosine phosphatase, catalytic
    1. SM00404 (ptp_7)
  4. Domain IPR000387
    Tyrosine specific protein phosphatases domain
    1. PS50056 (TYR_PHOSPH...)
  5. Domain IPR000242
    PTP type protein phosphatase
    1. PR00700 (PRTYPHPHTASE)
    2. PS50055 (TYR_PHOSPH...)
    3. SM00194 (PTPc_3)
    4. PF00102 (Y_phosphatase)
  6. SITE IPR016130
    Protein-tyrosine phosphatase, active site
    1. PS00383 (TYR_PHOSPH...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. cd00047 (PTPc)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site cd00047

Protein sequence

>MCA_05763_1
MPSNLSSPSANRISTPSNVDFDSELPSSSATSGSTTPAAAISPLPSNASYISHNPINKNIDEPCYFKSKLEFPPSTGYID
PNTKPTVLYPLTSFESKISAGPLSSKTNDSKTSIPISHSKKERRSKNYYPLHNKSRSKSPENPFFKNQSSFDDPDHKDAK
QNSNNQDKSNKPSSITLPSSPFPLRHPIDQNISSPNITYTNPSASQHGIPAHHNSTPTTIPSAPSFHHTITQHKFRSPSL
PVNSLMLPSVQQLPSTVQKIYPSEIEDLLPDEPEFSNTLPSFHPNIKTLFVDVRPYAQYSKSRIKTAINICLPSTLLKRP
TFTITRFGECMIPFQRPCIENLDQYDSVIIYDQSTEEMSTATYSPLLFTILKFSKAENLKGKLYYLHGGISLLQSKGSKL
YDSQFIDYSETTAQISKDGANNNNSGQPNLASNNPAAPHNSVSPSSSSSASSSFSSNSSASVASSVNSSDSPLKKLGTSH
TFNFPPVLTGFSLPFSSTKDGPIKPFASNLNHLLDNVDYDLSPVRLPDDMDPEELESYFPTWLKDVINPESGPSKIARRF
HDIEKAEKVRVNTAFQIKSQNNSSNMNSATPTIIPPVGVETKGNIDTTPSKPQYISLMIKPPLEDCFKTPQIPISTTSIN
GNNACNSCTTSDQPAGYFNIVPTEENLQAHSSTTGPLNNLNTPQEFHPKPDNNSNSYFVSNLNTSSEVPSEELLTPDDAE
FKYSFSAGVELGTKNRYSNIWPYDHTRVRLPETLIEESTHSTPVDNKDMGKIFSHSNNHKENDTESNDNSNIEENIDSPE
IIIDDTKKNLSQLKLNTKNASKNAHSDQISSSPTLKNSIKISTPTNKTSKNLADDNGNDYINASYLCAKGSRDRYIATQG
PLPDTFNDFWHLVWAKKISMIIMLTAEIEGGQIKCHRYWNDGIYGKLKLSLVSEEKRKLSNATGNFVTIRTFSLAPISYF
KSSLSSRSSSSSNTTPHTVVQIQYASWPDLGSPTNPDDLIEISQIKEEIMENLAKNAPKSDSSDTCSSQMKRYKPWVIVH
CSAGCGRTGTFCTVDSIIEFLKEHGIFALPRRYLLIRKPNNDFSSPAILTATTATIPKNDTSESFIDYFSSDRTTETQPS
LAVLPGEPSFENYDFVYRTVHDFRRQRLGMVQVLRQYVLCYETIIVWIHQRYLEEKKSKQKT

GO term prediction

Biological Process

GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

Molecular Function

GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity

Cellular Component

None predicted.