MCA_05694_1

Protein

Length

1,179 amino acids

Gene name: SMC2

Description: Structural maintenance of chromosomes protein 2

Browser: contigD:2060904-2064444-

RNA-seq: read pairs 653, FPKM 6.8, percentile rank 20.4% (100% = highest expression)

Protein function

Annotation:		SMC2	Structural maintenance of chromosomes protein 2
KEGG:	K06674	SMC2	structural maintenance of chromosome 2
EGGNOG:	0PH55	SMC2	structural maintenance of chromosomes protein
SGD closest match:	S000001927	SMC2	Structural maintenance of chromosomes protein 2
CGD closest match:	CAL0000192877	SMC2	Structural maintenance of chromosomes protein

Protein alignments

	%id	Aln length	E-value
MIA_00320_1	58.00%	1200	0.0	MIA_00320_1
A0A0J9XJR3_GEOCN	58.14%	1180	0.0	Structural maintenance of chromosomes protein OS=Geotrichum candidum GN=BN980_GECA22s01209g PE=3 SV=1
A0A060SZ72_BLAAD	54.37%	1179	0.0	Structural maintenance of chromosomes protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C02948g PE=3 SV=1
Q6C0G9_YARLI	47.71%	1178	0.0	Structural maintenance of chromosomes protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F24783g PE=3 SV=1
UniRef50_Q6C0G9	47.71%	1178	0.0	Structural maintenance of chromosomes protein n=2 Tax=Yarrowia lipolytica TaxID=4952 RepID=Q6C0G9_YARLI
A0A1D8PI59_CANAL	47.20%	1180	0.0	Structural maintenance of chromosomes protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC2 PE=3 SV=1
SMC2_YEAST	46.23%	1179	0.0	Structural maintenance of chromosomes protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC2 PE=1 SV=1
A0A167EUU2_9ASCO	48.90%	1047	0.0	Condensin subunit SMC2 OS=Sugiyamaella lignohabitans GN=SMC2 PE=4 SV=1
A0A1E4TCA6_9ASCO	40.02%	1207	0.0	Structural maintenance of chromosomes protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_139250 PE=3 SV=1
A0A1E3PLP0_9ASCO	30.90%	288	4e-24	Structural maintenance of chromosomes protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50270 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1381

Protein family membership

Structural maintenance of chromosomes protein (IPR024704)

Domains and repeats

Domain
1 - 172
Smc2, ATP-binding cassette domain (IPR027120)
Domain
1 - 218
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
482 - 694
SMCs flexible hinge (IPR010935)
1,081 - 1,166
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
3 - 1,172
RecF/RecN/SMC, N-terminal (IPR003395)

1 200 400 600 800 1000 1179

Detailed signature matches

IPR024704

Structural maintenance of chromosomes protein
1. PIRSF005719 (SMC)
  
  1 - 1,178
  
  PIRSF
  PIRSF005719 (SMC)
IPR027120

Smc2, ATP-binding cassette domain
1. cd03273 (ABC_SMC2_euk)
  
  1 - 172
  
  CDD
  cd03273 (ABC_SMC2_euk)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,081 - 1,166
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1 - 218
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003395

RecF/RecN/SMC, N-terminal
1. PF02463 (SMC_N)
  
  3 - 1,172
  
  Pfam
  PF02463 (SMC_N)
IPR010935

SMCs flexible hinge
1. PF06470 (SMC_hinge)
  
  522 - 644
  
  Pfam
  PF06470 (SMC_hinge)
2. SM00968 (SMC_hinge_2)
  
  521 - 644
  
  SMART
  SM00968 (SMC_hinge_2)
3. SSF75553 (Smc hinge...)
  
  482 - 694
  
  SUPERFAMILY
  SSF75553 (Smc hinge domain)

no IPR

Unintegrated signatures

Coil

298 - 318

COILS
Coil (Coil)

745 - 818

COILS
Coil (Coil)

274 - 294

COILS
Coil (Coil)

826 - 902

COILS
Coil (Coil)

178 - 198

COILS
Coil (Coil)

719 - 739

COILS
Coil (Coil)

685 - 712

COILS
Coil (Coil)

355 - 389

COILS
Coil (Coil)

910 - 944

COILS
Coil (Coil)

443 - 470

COILS
Coil (Coil)

988 - 1,036

COILS
Coil (Coil)

326 - 353

COILS
Coil (Coil)

477 - 504

COILS
Coil (Coil)
G3DSA:1.20.11...

319 - 792

GENE3D
G3DSA:1.20.1170.10 (G3DSA:1.20.1170.10)
G3DSA:1.20.12...

793 - 879

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)
G3DSA:3.40.50...

1 - 184

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

880 - 1,179

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

Residue annotation

Walker A/P-loop cd...

32G

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

33L

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

34N

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

35G

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

36S

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

37G

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

38K

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)

39S

Walker A/P-loop
32G, 33L, 34N, 35G, 36S, 37G, 38K, 39S
CDD
cd03273 (ABC_SMC2_euk)
ATP binding site c...

35G

ATP binding site
35G, 36S, 38K, 39S, 40N, 147Q
CDD
cd03273 (ABC_SMC2_euk)

36S

ATP binding site
35G, 36S, 38K, 39S, 40N, 147Q
CDD
cd03273 (ABC_SMC2_euk)

38K

ATP binding site
35G, 36S, 38K, 39S, 40N, 147Q
CDD
cd03273 (ABC_SMC2_euk)

39S

ATP binding site
35G, 36S, 38K, 39S, 40N, 147Q
CDD
cd03273 (ABC_SMC2_euk)

40N

ATP binding site
35G, 36S, 38K, 39S, 40N, 147Q
CDD
cd03273 (ABC_SMC2_euk)

147Q

ATP binding site
35G, 36S, 38K, 39S, 40N, 147Q
CDD
cd03273 (ABC_SMC2_euk)
Q-loop/lid cd03273

144L

Q-loop/lid
144L, 145I, 146M, 147Q
CDD
cd03273 (ABC_SMC2_euk)

145I

Q-loop/lid
144L, 145I, 146M, 147Q
CDD
cd03273 (ABC_SMC2_euk)

146M

Q-loop/lid
144L, 145I, 146M, 147Q
CDD
cd03273 (ABC_SMC2_euk)

147Q

Q-loop/lid
144L, 145I, 146M, 147Q
CDD
cd03273 (ABC_SMC2_euk)
ABC transporter si...

167E

ABC transporter signature motif
167E, 168A, 169A, 170G, 171T, 172R
CDD
cd03273 (ABC_SMC2_euk)

168A

ABC transporter signature motif
167E, 168A, 169A, 170G, 171T, 172R
CDD
cd03273 (ABC_SMC2_euk)

169A

ABC transporter signature motif
167E, 168A, 169A, 170G, 171T, 172R
CDD
cd03273 (ABC_SMC2_euk)

170G

ABC transporter signature motif
167E, 168A, 169A, 170G, 171T, 172R
CDD
cd03273 (ABC_SMC2_euk)

171T

ABC transporter signature motif
167E, 168A, 169A, 170G, 171T, 172R
CDD
cd03273 (ABC_SMC2_euk)

172R

ABC transporter signature motif
167E, 168A, 169A, 170G, 171T, 172R
CDD
cd03273 (ABC_SMC2_euk)

Protein sequence

>MCA_05694_1
MKIEELIIDGFKSYATRTVISQWDSSFNCITGLNGSGKSNILDAICFVLGITTMNVVRAQNLQDLIYKRGQAGVTKASVT
IIFDNGDKSKSPIGFEDQSHISVTRQVVMGGTSKYLINGHRAQQTTVQQLFQSVQLNVNNPNFLIMQGRITKVLNMKPTE
ILALIEEAAGTRMFEERREKAIKTMAKKEKKVEEINALLQEEVLPKLEKLRTEKRQFIEYQQVQNQLERATKLVVSHDYV
EISETLKQMSASFSSTTSHSNALKKLVEKSHLEIDSLNQQIFDIKQQREEEAKRVGSLEGLEKKVKDLSEEKARLKAHGD
LQSSNLKQLEQSLSKILSTIEKLESEKKKYSEDGVGEYEVSYNKANAELQALISERDKKEELLQSLQTGVASKEGQASGY
GNEIQQIRDQAMNAETSKTNSYARLESISNDIKNDQDKTLNAQRELSKLSKDLEQRKSQLQSLESQLAQQGFVPGRLDQL
SAREKELKSQIHSLNQQIDFSKRRVANIDFKFKPPNGFDTSSVKGVVAQLFSLEEKNYEAATALEVAAGGKLYQVVVDTD
TTATQIIKHGQLKRRVTIIPLNRVSALGFAKVSQKLGAAQKIAPGKVDIALNLIGYDHEVERAMQYVFGNALICSDNESA
RKVAFHPQIRVKTVTLDGDIYDPRGTLSGGSDRNKGNQESFLISLQKINDMVKQQRELVNELRSIRMEIQQESNLFSQNK
ELKVQFDLKTHEMQLLEKKLNDGPAAKILQLNQKRQAQIKELEEEIAKADETISKCAKEIKKLEKEMKEFKTNKSGKLKE
LQDVVTQLRHQVARKTLEVQEKKARLQEFQMGSQQYEGELQSAQEESAMLQKSIAELQAELSELEEKYMQIDEKEKKAMS
KYEEEKSRFLGLDQELNSLEKTLNTKQKFLSENKLQLQKATHELGKLEHDIKSLQNKFNKLVETYEWVSTEAQFFGQEGS
PYNFYEVSNMSLLREELAKLNQRSHGMKKSLNEKVMNTLERMENKEETLHKMITTIEKDKRKIEETIVQLDDYKRKALEK
TWVQVSEDLGKIFGDLLPGSTSKLVTLENRSVTEGLEVKVALGGVWKDSLTELSGGQRSLVALSLIMALLQFKPAPMYIL
DEVDAALDLNHTQNIGQIIKTRFKGAQFIVVSLKEGMFTNANRIFRTRFTEGTSTVTVS

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features