Protein

MCA_05670_1

Length
1,228 amino acids

Gene name: RGA1

Description: Rho-type GTPase-activating protein

Browser: contigD:1982502-1986496-

RNA-seq: read pairs 2268, FPKM 22.8, percentile rank 44.9% (100% = highest expression)

Protein function

Annotation:RGA1Rho-type GTPase-activating protein
KEGG:K19839RGA1_2 Rho-type GTPase-activating protein 1/2
EGGNOG:0PHGZRGA2Rho-type gtpase-activating protein
SGD closest match:S000005653RGA1Rho-type GTPase-activating protein 1
CGD closest match:CAL0000179204RGA2Rga2p

Protein alignments

%idAln lengthE-value
A0A0J9XHN8_GEOCN43.87%6528e-129Similar to Saccharomyces cerevisiae YOR127W RGA1 GTPase-activating protein for the polarity-establishment protein Cdc42p OS=Geotrichum candidum GN=BN980_GECA17s00395g PE=4 SV=1
UniRef50_A0A0J9XHN843.87%6522e-125Similar to Saccharomyces cerevisiae YOR127W RGA1 GTPase-activating protein for the polarity-establishment protein Cdc42p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHN8_GEOCN
MIA_04284_167.98%2032e-81MIA_04284_1
A0A1E3PDK3_9ASCO34.70%7091e-79Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84163 PE=4 SV=1
A0A167D146_9ASCO59.09%1985e-68Rga1p OS=Sugiyamaella lignohabitans GN=RGA1 PE=4 SV=1
Q6CF51_YARLI77.69%1302e-62YALI0B10241p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B10241g PE=4 SV=1
A0A060T1E4_BLAAD54.00%2006e-61ARAD1C15928p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15928g PE=4 SV=1
Q5AMQ3_CANAL67.74%1243e-54Rga2p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RGA2 PE=4 SV=1
A0A1E4TFU9_9ASCO73.64%1103e-52Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31537 PE=4 SV=1
RGA1_YEAST49.11%1125e-34Rho-type GTPase-activating protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGA1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0060

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1228

Detailed signature matches

  1. Domain IPR001781
    Zinc finger, LIM-type
    1. PF00412 (LIM)
    2. PS50023 (LIM_DOMAIN_2)
    3. PS00478 (LIM_DOMAIN_1)
    4. SM00132 (lim_4)
  2. Domain IPR008936
    Rho GTPase activation protein
    1. SSF48350 (GTPase ac...)
  3. Domain IPR000198
    Rho GTPase-activating protein domain
    1. SM00324 (RhoGAP_3)
    2. PF00620 (RhoGAP)
    3. PS50238 (RHOGAP)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.55...
  3. G3DSA:1.20.5.340
  4. G3DSA:2.10.11...
  5. cd00159 (RhoGAP)
  6. cd09394 (LIM1_Rga)
  7. cd09395 (LIM2_Rga)
  8. mobidb-lite (disord...)

Residue annotation

  1. Zn binding site cd...
  2. Zn binding site cd...
  3. catalytic residue ...
  4. GTPase interaction...

Protein sequence

>MCA_05670_1
MDSTDSTPSVDNDDESQYCKKCNKILEEGRAYELGGDRWHVECFRCSSCNTQLGCTTNLLVLGNGSLICSNCSYHCSVCH
KKIEDLAILTGDQAFCSSCFCCRNCKKKIDDLQYARTSLGIFCMTCHQALLARKKKAAAMKANGSSGTATSSSTSNTPPP
VVTSNSGLISSNPLTNLNQNNLNNISSTYSKAYSPGTANTPPSLASPNQSYPLNPSSSLPMNYTSTPNFLSRHGSNSFKE
KSLPSLPNEEPPLNYPVAHPQASVSPTSIIQPTNAIPSSMKSVLSSPPGSSSPSQSPNSLSNPSPPTRPSQPAFDPALVR
IPQRSQHASSNSRSVSISSEASGTSNNPNASPSTVPTTITSTVCPTSPNPTHNHSSDINTPLSSQSSTNTSLGQSEASKT
RNSRGLMRSSSVKKTETIDSIRRKAKSPDLVPSIPLDSLRNRSNASASSNASRGGLYLDSSIPLTSSTPDSSLESGSFID
HNNGTYPSSTSSFSNSSSSENLSKLVLERSVLRSTSPHPANQYEAPTSSSSTVRPFDPIPPIHLLGKDENYSAYPPSSSN
KYGLSQGLTINTKGPKSSPGNTTMTTPTQGHYRSASDNPLPTPTFSLKYSSFDDATTSNSISSSNMAKELSEARSRIAEL
EAQLSKKENTHNLENSIQEKRKTIAGLEAKGKVAEKELRALEEARNRSDSLNDCRADLVTVFTNEITQVKKSLQAEIENL
VLERDKLVEETTELLKKRDSLQDEMNYLITKNNHLHDLHLELARQAVEKFGPYAKFGNTSFNLSKELSNGSNSSDHTRGI
FSSGSNHLEDLDTIEDKKAHKGRFWKRPTAAMAKGVKGFNKVFQQDPQAQHSVHTISNGPYIDGSPNDSNELTNSSSNSN
DSNDSNNHGNNDNQNNGNDTDNNTNAESYNDGTIKSSKQRNGWFRSGSQNDTTNSHNTHNNTSNNSATSNPSQLMGNSIE
NRIEYEGTKIPFIVTRCIQEVEERGIDMEGIYRKSGGRSQVSSIEEAFENMPPNSVGDDFNEILSGDISGVTSALKQYLR
HLPNPLIPYEHYDSFVEASKSCSDSNLRQVINALPQAYKECLTFVIHHLAKVAQHSEVNLMTTRNLAVVFAPTLVRHTNG
EREILDMQPRNDGTQMLIEKYSTIFSDVVITDEIALKVINGTIGDKTLTTQGNGNKNNNSSLENNNRKTSSETGRFSEGL
KPDDSMSTGTHSNTSSMLGPPMSIANVI

GO term prediction

Biological Process

GO:0007165 signal transduction

Molecular Function

None predicted.

Cellular Component

None predicted.