Protein
MCA_05643_1
Length
503 amino acids
Gene name: ERG4
Description: Delta(24(24(1)))-sterol reductase
Browser: contigD:1905315-1906827+
RNA-seq: read pairs 6040, FPKM 148.1, percentile rank 84.7% (100% = highest expression)
Protein function
| Annotation: | ERG4 | Delta(24(24(1)))-sterol reductase | |
|---|---|---|---|
| KEGG: | K00223 | ERG4 | Delta24(24(1))-sterol reductase [EC:1.3.1.71] |
| EGGNOG: | 0PFUR | ERG4 | )-reductase |
| SGD closest match: | S000002980 | ERG4 | Delta(24(24(1)))-sterol reductase |
| CGD closest match: | CAL0000199354 | ERG4 | Delta(24(24(1)))-sterol reductase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_00018_1 | 71.31% | 474 | 0.0 | MIA_00018_1 |
| A0A0J9XAZ3_GEOCN | 70.34% | 472 | 0.0 | Similar to Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase OS=Geotrichum candidum GN=BN980_GECA07s03442g PE=4 SV=1 |
| A0A167EQY0_9ASCO | 64.47% | 456 | 0.0 | Delta(24(24(1)))-sterol reductase OS=Sugiyamaella lignohabitans GN=ERG4 PE=4 SV=1 |
| A0A060THR7_BLAAD | 63.17% | 467 | 0.0 | ARAD1D39996p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39996g PE=4 SV=1 |
| UniRef50_A0A0E9N900 | 55.97% | 461 | 2e-172 | Uncharacterized protein n=2 Tax=Saitoella complicata NRRL Y-17804 TaxID=698492 RepID=A0A0E9N900_9ASCO |
| Q6C8J1_YARLI | 55.80% | 457 | 4e-178 | YALI0D19206p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D19206g PE=4 SV=1 |
| A0A1E4TG65_9ASCO | 53.45% | 464 | 1e-173 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2426 PE=4 SV=1 |
| ERG4_YEAST | 52.15% | 466 | 1e-163 | Delta(24(24(1)))-sterol reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG4 PE=1 SV=2 |
| A0A1D8PJ25_CANAL | 51.12% | 448 | 2e-156 | Delta(24(24(1)))-sterol reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG4 PE=4 SV=1 |
| A0A1E3PQ03_9ASCO | 49.30% | 503 | 4e-155 | ERG4/ERG24 ergosterol biosynthesis protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49810 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.2076
Predicted cleavage: 19
Protein family membership
- Ergosterol biosynthesis ERG4/ERG24 (IPR001171)
Domains and repeats
None predicted.
Detailed signature matches
-
-
PF01222 (ERG4_ERG24)
-
no IPR
Unintegrated signatures
-
CYTOPLASMIC_D... (C...)
-
NON_CYTOPLASM... (N...)
-
-
TRANSMEMBRANE (Tran...)
-
mobidb-lite (disord...)
Protein sequence
>MCA_05643_1 MASTTSVSQGDSSVKNRSTAKSASSDSSKEPYTPCITTLKDELAKNPDGLKVRISDPYAQHGEFQYEFGGPVGVTSMMIG FPLLMWYLFVCYKYYDCKLALPAKDQSFIDFIKQLVHYAYEGAYPTRQAWAIEWGFLIFQAILYVYLPGGIWTEGSPFPQ NGNRGLQYYCSAVQSLYFSTFVALALHFSGIFKLYTIIDRFGEIMSVAIISGFLISFFVYFRSIIEGTQVRMTGIFVYDF FMGAPLYPRIGKTLDLKMFFEVRLPWYTLYFLALAAVLKQYNDYGYVSFNLFHAFFSIWLFANACSKGEHLIIPSWDIFY EKFGFMLIFWNIAGVPFTYCYNTLYLVSHDPATYKHSTLYNTVMFVTLLVAHYFFDTTNGQKNSFRQQIAGTFKPRKAFP QLPWVTIENPTFIKCKNGGTLLADGWYRYAARKIHYTVDFIQNMTWALNCGFHSPLPYFYPAFFLGMILHRASRDEQKCA EKYGEDWEAYKKICPYRFIPGIY
GO term prediction
Biological Process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
Cellular Component
GO:0016020 membrane