Protein

MCA_05614_1

Length
452 amino acids

Gene name: IPL1

Description: Serine/threonine protein kinase Ipl1, Aurora kinase of chromosomal passenger complex; in S. cerevisiae plays a role as spindle assembly checkpoint kinase.

Browser: contigD:1803148-1804507+

RNA-seq: read pairs 1244, FPKM 33.9, percentile rank 56.2% (100% = highest expression)

Protein function

Annotation:IPL1Serine/threonine protein kinase Ipl1, Aurora kinase of chromosomal passenger complex; in S. cerevisiae plays a role as spindle assembly checkpoint kinase.
KEGG:K08850AURKX aurora kinase, other [EC:2.7.11.1]
EGGNOG:0PFYFIPL1serine threonine-protein kinase
SGD closest match:S000006130IPL1Spindle assembly checkpoint kinase
CGD closest match:CAL0000183313IPL1Spindle assembly checkpoint kinase

Protein alignments

%idAln lengthE-value
A0A0J9XJN3_GEOCN62.83%4521e-179Similar to Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase subunit of the conserved chromosomal passenger complex CPC OS=Geotrichum candidum GN=BN980_GECA24s00549g PE=3 SV=1
MIA_06268_179.67%3002e-170MIA_06268_1
A0A060THZ4_BLAAD57.73%4597e-158ARAD1D42064p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D42064g PE=3 SV=1
A0A167EH36_9ASCO72.52%3134e-156Aurora kinase OS=Sugiyamaella lignohabitans GN=IPL1 PE=3 SV=1
A0A1E3PQL5_9ASCO68.87%3025e-139Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_21761 PE=3 SV=1
UniRef50_B6JZ1563.93%2806e-122AUR protein kinase Ark1 n=16 Tax=Eukaryota TaxID=2759 RepID=B6JZ15_SCHJY
A0A1E4TK36_9ASCO69.08%2623e-126Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_18595 PE=3 SV=1
IPL1_YARLI60.69%3183e-118Spindle assembly checkpoint kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=IPL1 PE=3 SV=1
IPL1_YEAST54.74%2855e-110Spindle assembly checkpoint kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IPL1 PE=1 SV=1
IPL1_CANAL51.39%2887e-96Spindle assembly checkpoint kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IPL1 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4253

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 452

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. PIRSF000654 (ILK)
  4. cd14007 (STKc_Aurora)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. active site cd14007
  3. polypeptide substr...
  4. activation loop (A...

Protein sequence

>MCA_05614_1
MSVSNLESRLARVSISENPVPLTKQKLRPSNLSKNNPANGATTSESRKPLVKLTNGQSQPKSTSSKTGTSSSAKNTLPVV
KINPERWRLSTNSGLSSIPSTSKKTNNNTSSNSSASTTTSQTTASSKTQNKKTVSTIDPNTIRLSNPLSGIKVRNSSALL
YNSTGNSPLSNGNSGPTYRQFSLSDFEIGKKLGKGKFGKVYCVRDKLSGYICALKVMSKKELIEYKVEKQFRREVEIQSN
LLHPNISRLFGHFHDDKNVYLLIEYVAQGELFKVLRRMGTFNDVRASKYIYQMSLALIYLHKKHIIHRDIKPENILLGLD
GNIKISDFGWSVHSPSPSTRRTTMCGTLDYLPPEMVEAKDHDYRVDIWSLGILTYEFLVGNPPFEESGHAATYKRISKVD
LRIPPTVSPEAADIIKRFLQHSPEKRFPLEKVATHPWIVKNKPYWDSPEHLG

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.