Protein

MCA_05569_1

Length
246 amino acids

Gene name: MDE1

Description: Methylthioribulose-1-phosphate dehydratase

Browser: contigD:1671360-1672154-

RNA-seq: read pairs 2792, FPKM 139.7, percentile rank 84.0% (100% = highest expression)

Protein function

Annotation:MDE1Methylthioribulose-1-phosphate dehydratase
KEGG:K08964mtnB methylthioribulose-1-phosphate dehydratase [EC:4.2.1.109]
EGGNOG:0PHCCMDE1Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
SGD closest match:S000003785MDE1Methylthioribulose-1-phosphate dehydratase
CGD closest match:CAL0000179829MDE1Methylthioribulose-1-phosphate dehydratase

Protein alignments

%idAln lengthE-value
A0A0J9XHS1_GEOCN79.57%2353e-142Methylthioribulose-1-phosphate dehydratase OS=Geotrichum candidum GN=MDE1 PE=3 SV=1
MIA_00889_175.42%2405e-135MIA_00889_1
A0A1E3PPI5_9ASCO78.51%2281e-134Methylthioribulose-1-phosphate dehydratase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=MDE1 PE=3 SV=1
A0A060T4F5_BLAAD76.44%2252e-132Methylthioribulose-1-phosphate dehydratase OS=Blastobotrys adeninivorans GN=MDE1 PE=3 SV=1
MTNB_YARLI73.71%2323e-129Methylthioribulose-1-phosphate dehydratase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MDE1 PE=3 SV=1
MTNB_YEAST62.23%2333e-100Methylthioribulose-1-phosphate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDE1 PE=1 SV=1
UniRef50_P4709562.23%2337e-97Methylthioribulose-1-phosphate dehydratase n=39 Tax=Saccharomycetales TaxID=4892 RepID=MTNB_YEAST
MTNB_CANAL62.23%2336e-97Methylthioribulose-1-phosphate dehydratase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDE1 PE=3 SV=1
A0A167CHH7_9ASCO76.92%1693e-91Methylthioribulose 1-phosphate dehydratase MDE1 OS=Sugiyamaella lignohabitans GN=MDE1 PE=4 SV=1
A0A1E4TJX1_9ASCO34.11%2141e-25Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30334 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1311
Predicted cleavage: 12

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 246

Detailed signature matches

  1. Family IPR017714
    Methylthioribulose-1-phosphate dehydratase
    1. TIGR03328
  2. Family IPR027514
    Methylthioribulose-1-phosphate dehydratase, eukaryotes
    1. MF_03116 (Salvage_M...)
  3. Domain IPR001303
    Class II aldolase/adducin N-terminal
    1. SSF53639 (AraD/HMP-...)
    2. SM01007 (Aldolase_II_2)
    3. G3DSA:3.40.22...
    4. PF00596 (Aldolase_II)

Protein sequence

>MCA_05569_1
MASVPSAPIRKATGPDELVISHDSNHPANLICELCKLFYDKDWVTGTGGGMSIRDGDLVYLAPSGVQKERMKPENMFVMD
LKTQEYIKTPDIYKPSACTPLFLSAYTMRGAGACIHTHSQAAVMVSLLYDKEFRIANIEQIKAIPKVTEPGYLSFFDTLV
IPIIDNVAHEEDLTPFLQKALEEYPSTTAVLVRRHGIYVWGESVWKAKIINEAIDYLLELAVKMVGMGIKPDGEIGSEKK
CQHYLN

GO term prediction

Biological Process

GO:0019509 L-methionine salvage from methylthioadenosine

Molecular Function

GO:0046872 metal ion binding

Cellular Component

GO:0005737 cytoplasm