Protein

MCA_05557_1

Length
415 amino acids

Gene name: RPT4

Description: 26S proteasome subunit RPT4; ATPase of the 19S regulatory particle of the 26S proteasome

Browser: contigD:1639583-1640997+

RNA-seq: read pairs 5250, FPKM 155.9, percentile rank 85.3% (100% = highest expression)

Protein function

Annotation:RPT426S proteasome subunit RPT4; ATPase of the 19S regulatory particle of the 26S proteasome
KEGG:K03064PSMC6 26S proteasome regulatory subunit T4
EGGNOG:0PG6YRPT4regulatory subunit
SGD closest match:S000005785RPT426S proteasome subunit RPT4
CGD closest match:CAL0000188624RPT4Proteasome regulatory particle base subunit

Protein alignments

%idAln lengthE-value
MIA_02138_191.60%4050.0MIA_02138_1
A0A0J9X567_GEOCN90.48%3990.0Similar to Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates OS=Geotrichum candidum GN=BN980_GECA03s00384g PE=3 SV=1
A0A060TA07_BLAAD89.45%3980.0ARAD1B03960p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B03960g PE=3 SV=1
Q6C516_YARLI87.37%3960.0YALI0E21868p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E21868g PE=3 SV=1
A0A1E3PPF5_9ASCO84.31%4080.0Putative 26S protease subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81750 PE=3 SV=1
Q5A6S2_CANAL82.17%4150.0Proteasome regulatory particle base subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RPT4 PE=3 SV=1
A0A1E4TA56_9ASCO84.76%3740.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3262 PE=3 SV=1
PRS10_YEAST75.30%4210.026S proteasome subunit RPT4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPT4 PE=1 SV=4
UniRef50_O7444579.03%3720.0Probable 26S proteasome subunit rpt4 n=262 Tax=Eukaryota TaxID=2759 RepID=PRS10_SCHPO
A0A167DYI9_9ASCO94.78%2680.0Proteasome regulatory particle base subunit RPT4 OS=Sugiyamaella lignohabitans GN=RPT4 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0128

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 415

Detailed signature matches

  1. Family IPR005937
    26S proteasome regulatory subunit P45-like
    1. TIGR01242
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR003593
    AAA+ ATPase domain
    1. SM00382 (AAA_5)
  4. Domain IPR003959
    ATPase, AAA-type, core
    1. PF00004 (AAA)
  5. SITE IPR003960
    ATPase, AAA-type, conserved site
    1. PS00674 (AAA)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.8.60
  3. G3DSA:3.40.50...
  4. cd00009 (AAA)
  5. mobidb-lite (disord...)

Residue annotation

  1. Walker A motif cd0...
  2. ATP binding site c...
  3. Walker B motif cd0...
  4. arginine finger cd...

Protein sequence

>MCA_05557_1
MSAEEERDPLLAALEDEVGEEEASAPVDPEREKALNDFKKKLKEHREWDAKLKDLRIQIKELDKQFEKTEDDIKALQSLG
QLIGEVLKQLDEERFIVKSSNGPRYIVGCRNSIDKASLKQGVRVALDMTTLTIMRILPREVDPLVYNMTTFEPGSLTFGG
IGGLNEQIRELREVIELPLKNPELFHRVGINPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPASAIVDKYIGESARL
IREMFGYAKEHAPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDYLGQTKVIMATNRPDTLDPALLRAGR
LDRKIEIPLPNEVGRLEIFKIHAADVQKQGEFDYEALVKLSDGFNGADIRNVVTEAGFFAIRDDRDYILQNDMMKAVRKV
AEAKKLEGKLEYEKL

GO term prediction

Biological Process

GO:0030163 protein catabolic process

Molecular Function

GO:0005524 ATP binding
GO:0016787 hydrolase activity

Cellular Component

GO:0005737 cytoplasm