MCA_05555_1
Gene name: CDC60
Description: Leucine--tRNA ligase, cytoplasmic
Browser: contigD:1634194-1637580-
RNA-seq: read pairs 9500, FPKM 106.5, percentile rank 79.8% (100% = highest expression)
Protein function
| Annotation: | CDC60 | Leucine--tRNA ligase, cytoplasmic | |
|---|---|---|---|
| KEGG: | K01869 | LARS | leucyl-tRNA synthetase [EC:6.1.1.4] |
| EGGNOG: | 0PGGF | CDC60 | Leucyl-tRNA synthetase |
| SGD closest match: | S000006081 | CDC60 | Leucine--tRNA ligase, cytoplasmic |
| CGD closest match: | CAL0000201312 | CDC60 | Leucine--tRNA ligase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02140_1 | 79.78% | 1093 | 0.0 | MIA_02140_1 |
| A0A0J9XGU8_GEOCN | 72.64% | 1093 | 0.0 | Similar to Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase OS=Geotrichum candidum GN=BN980_GECA15s03090g PE=4 SV=1 |
| A0A060T503_BLAAD | 69.65% | 1094 | 0.0 | ARAD1B04004p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B04004g PE=4 SV=1 |
| A0A1E3PP14_9ASCO | 68.28% | 1094 | 0.0 | Leucyl-tRNA synthetase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49613 PE=4 SV=1 |
| A0A167DYF8_9ASCO | 69.71% | 1050 | 0.0 | Leucine--tRNA ligase CDC60 OS=Sugiyamaella lignohabitans GN=CDC60 PE=4 SV=1 |
| Q6C4Q2_YARLI | 66.48% | 1092 | 0.0 | YALI0E24607p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E24607g PE=4 SV=1 |
| A0A1D8PS12_CANAL | 63.01% | 1095 | 0.0 | Leucine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC60 PE=4 SV=1 |
| SYLC_YEAST | 64.42% | 1096 | 0.0 | Leucine--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC60 PE=1 SV=1 |
| UniRef50_P26637 | 64.42% | 1096 | 0.0 | Leucine--tRNA ligase, cytoplasmic n=432 Tax=Fungi TaxID=4751 RepID=SYLC_YEAST |
| A0A1E4TA44_9ASCO | 60.25% | 1112 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_125746 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0166
Protein family membership
Domains and repeats
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Domain
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Domain
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Domain
Detailed signature matches
no IPR
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SSF52374 (Nucleotid...)
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cd00812 (LeuRS_core)
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cd07959 (Anticodon_...)
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mobidb-lite (disord...)
Residue annotation
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active site cd00812
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KMSKS motif cd00812
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tRNA binding surfa...
Protein sequence
>MCA_05555_1 MVAPAKPESAAPKAEPKTIVLENTARRDALIAIEKKYQKIWQDENLFAVDAPESEGISAAELRKKYPKYFATMAYPYMNG VLHAGHSFTLSKVEFAVGYERLLGKRALFPLGFHCTGMPIKASSDKLVREIELFGENFENAPGDDEEEEPEQETKKPKAK EDVEKFSSKKSKAAAKQGRAKYQFEIMKQLGVPVEEIKKFADPTYWLTYFPPLCKEDCTNFGARIDWRRGFVTTDYNPYY DSFVRWQMNRLHALGKIKFGERYTIYSAKDGQPCMDHDRASGEGVAPQEYTGIKIEVKEFPEAAQKALADVDLSGKKVYL VAATLRPETMYGQTCCFVSPKITYGLYDAGNNEYFICTERAFKNMCFQKLTPKRGNWDSVAKIDGSALIGALIEAPLAVY KDLRVLPMETVLANKGTGVVTCVPSDSPDDYITSIDLANKPEYYKINKDWVKVDPVAIIETPTYGTLTAKTLVEQLKIRS PKDKDLLTKAKELAYKEGFYQGVMVTGPYKGEKVEVAKPKVKADLIKAGQAFVYNEPENQVISRSGDDCVVSLEDQWFTD YGEESWKAQAEKCLNDMNTFSVETRNGFEKVLDWLNNWALSRTYGLGTRIPWDEKYLVESLSDSTIYMAFQAIAHLLQGD FYGKVPGALGIKSDELNDDFWDYVLLHKDDAKTSIPKEKLDKIRNEFEYFYPLDVNISGKDLIGNHLTFFIYCHCAIFPE EFWPAGIRANGHLLLNNEKMSKSTGNFMTLKQVVEKFGADAARIALADAGDSFEDANFDETNANAAILRLFNLKEWAEEV MSSDSNLRTGPKDTVFDKAFDNEMNQLISETKKAYDDAFYKVALKCGLFDLQSARDYYRDSTTTSGIGMHKDLVRRYIEV QALLLSPIAPHFCEYLWREVLKNEGSIQNAKFPTVSQPINKEMSAALEYLRDVQRTIREVEGANLKKKKGKGPVFDPKAP SKLTLYVASKFPEWQDSYIDLVKEAFEGMSLEFTPEFRQKVSKLGDVKRGMQFVNHLKTRLAQEPAETVFNRKLIFDELD TLKNTLPVVKKAPTSTNIQQIQVVSVADGIDIITGESVEVPTTKAVQDAVPGHPGITITNI
GO term prediction
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
Molecular Function
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
Cellular Component
GO:0005737 cytoplasm