Protein

MCA_05514_1

Length
540 amino acids

Gene name: ADE4

Description: Amidophosphoribosyltransferase

Browser: contigD:1523301-1525246-

RNA-seq: read pairs 5626, FPKM 128.5, percentile rank 82.7% (100% = highest expression)

Protein function

Annotation:ADE4Amidophosphoribosyltransferase
KEGG:K00764purF amidophosphoribosyltransferase [EC:2.4.2.14]
EGGNOG:0PGCVADE4Glutamine phosphoribosylpyrophosphate amidotransferase
SGD closest match:S000004915ADE4Amidophosphoribosyltransferase
CGD closest match:CAL0000174536ADE4Amidophosphoribosyltransferase

Protein alignments

%idAln lengthE-value
MIA_04523_184.92%5240.0MIA_04523_1
A0A0J9YHC0_GEOCN81.14%5250.0Amidophosphoribosyltransferase OS=Geotrichum candidum GN=BN980_GECA01s02199g PE=3 SV=1
A0A167FB25_9ASCO74.29%5290.0Amidophosphoribosyltransferase OS=Sugiyamaella lignohabitans GN=ADE4 PE=3 SV=1
Q6CEI8_YARLI74.77%5390.0Amidophosphoribosyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B15304g PE=3 SV=1
A0A1E4TA99_9ASCO63.54%5650.0Amidophosphoribosyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3330 PE=3 SV=1
A0A1D8PE37_CANAL67.41%5400.0Amidophosphoribosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE4 PE=3 SV=1
A0A1E3PP73_9ASCO70.12%5020.0Amidophosphoribosyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_73867 PE=3 SV=1
A0A060T7B6_BLAAD70.93%4850.0Amidophosphoribosyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C20152g PE=3 SV=1
PUR1_YEAST64.07%5260.0Amidophosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE4 PE=1 SV=2
UniRef50_P4139057.54%5370.0Amidophosphoribosyltransferase n=263 Tax=root TaxID=1 RepID=PUR1_SCHPO

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4969
Predicted cleavage: 14

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 540

Detailed signature matches

  1. Family IPR005854
    Amidophosphoribosyltransferase
    1. PIRSF000485 (Pur1)
    2. MF_01931 (PurF)
    3. TIGR01134
  2. Domain IPR029055
    Nucleophile aminohydrolases, N-terminal
    1. G3DSA:3.60.20.10
    2. SSF56235 (N-termina...)
  3. Domain IPR017932
    Glutamine amidotransferase type 2 domain
    1. PS51278 (GATASE_TYPE_2)
  4. Domain IPR035584
    Amidophosphoribosyltransferase, N-terminal
    1. cd00715 (GPATase_N)
  5. Domain IPR029057
    Phosphoribosyltransferase-like
    1. SSF53271 (PRTase-like)
  6. Domain IPR000836
    Phosphoribosyltransferase domain
    1. cd06223 (PRTases_typeI)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. PF13522 (GATase_6)

Residue annotation

  1. tetramer interface...
  2. active site cd00715
  3. active site cd06223

Protein sequence

>MCA_05514_1
MSSPLNNQIIPRFKGLLLSDPSASASGELLEGAHFLQHRGQDAAGIVTCGPGGRLYQCKGNGMARDVFTQARISLLAGNM
GIGHLRYPTAGSFANSEAQPFYVNSPYGIVMSHNGNLVNAPALRKYLDEVVHRHINTDSDSELLLNIFAAELQNTNKSRV
NDEDIFNALAGLYKQVRGAYACTGMIAGYGIMGFRDPNGIRPLVLGIRHKEDGSKDYMFSSESVLLQTLGYKEWFDIKPG
QAVIIPKGTMTPVFRQVVPQLSYSPDIFEYVYFARPDSVMDGISVYRSRLAMGDKLAENIISRFPSREAMMAEIDVVIPV
PDTSRTSALECAVRLGIPYREGFVKNRYVGRTFIMPNQTERKSSVRRKLNAMDMEFEGHNVLLVDDSIVRGTTSKEIVQM
AREAGAKKVYFASCAPPIRHNHIYGIDLADTKALVAYERSEDEISKTIGADQVFYQGLDDLIDACKSVQKETSEPIKDFE
VGVFNGQYITGVEESYLEYLEKIRGQNQRLKEQERHGLAALIEDPKAEVDIGLFNHGDIV

GO term prediction

Biological Process

GO:0009113 purine nucleobase biosynthetic process
GO:0009116 nucleoside metabolic process

Molecular Function

GO:0004044 amidophosphoribosyltransferase activity

Cellular Component

None predicted.