Protein

MCA_05508_1

Length
420 amino acids

Gene name: EAF3

Description: Chromatin modification-related protein EAF3

Browser: contigD:1498265-1499636+

RNA-seq: read pairs 2122, FPKM 62.3, percentile rank 70.0% (100% = highest expression)

Protein function

Annotation:EAF3Chromatin modification-related protein EAF3
KEGG:K11339MORF4L1 mortality factor 4-like protein 1
EGGNOG:0PMN5EAF3Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity)
SGD closest match:S000006227EAF3Chromatin modification-related protein EAF3
CGD closest match:CAL0000193590EAF3Chromatin modification-related protein EAF3

Protein alignments

%idAln lengthE-value
MIA_02660_158.45%4268e-169MIA_02660_1
A0A0J9XES4_GEOCN49.78%4461e-137Similar to Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor OS=Geotrichum candidum GN=BN980_GECA11s00615g PE=4 SV=1
UniRef50_A0A0J9XES449.78%4462e-134Similar to Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XES4_GEOCN
A0A1E3PNT4_9ASCO46.34%4102e-115MRG-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45215 PE=4 SV=1
A0A060T7N6_BLAAD43.45%4124e-114ARAD1D00968p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00968g PE=4 SV=1
A0A167CQA4_9ASCO45.30%4151e-110Eaf3p OS=Sugiyamaella lignohabitans GN=EAF3 PE=4 SV=1
EAF3_YARLI38.83%4613e-89Chromatin modification-related protein EAF3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=EAF3 PE=3 SV=1
A0A1E4TJJ3_9ASCO37.17%4175e-84Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_18276 PE=4 SV=1
EAF3_YEAST30.00%4302e-51Chromatin modification-related protein EAF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EAF3 PE=1 SV=1
EAF3_CANAL26.98%4301e-46Chromatin modification-related protein EAF3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=EAF3 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0335

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 420

Detailed signature matches

  1. Domain IPR016197
    Chromo domain-like
    1. SSF54160 (Chromo do...)
  2. Domain IPR025995
    RNA binding activity-knot of a chromodomain
    1. PF11717 (Tudor-knot)
  3. Domain IPR026541
    MRG domain
    1. PF05712 (MRG)
    2. PS51640 (MRG)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.30.30...
  2. cd00024 (CHROMO)
  3. mobidb-lite (disord...)

Residue annotation

  1. histone binding si...

Protein sequence

>MCA_05508_1
MAPSFPQKCLAFHGPMLYEAKTIKIWDPEAKTVRTKASENSGDQFASQGVVPPDLPAELENKIAYYIHYKGWKSTWDEWV
SDDRVLAWNEENLRTQKELKQMALAAASKKRHGGSSASSVAISVVPGGHYSMGANGYSEGAGPSSYKEESDFDGEDDSSK
GDRSSPLEASGSKRRESYKDDSSHTSRGTKRGRTVDMDLEREEDYIRKPEVSLNVPDVLKSLLVDDWRFITKEHQLVTLP
RDITVTDIIEMFRNSSHNPTKSSDKSKDKSSSADGSSGASGSANVSNGSTPSRRKSSLVSLHGSAEAEIFDEVLSGIKLY
FDRALGNILLYRFERQQYLQIKQKFPDKSLCDIYGAEHLLRLFVSFPALIAQTNMDQQSIVVLREHLEEFLKFMVENRRK
LFLTEYESTSPQYEAVSRSF

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.