Protein
MCA_05491_1
Length
228 amino acids
Gene name: DFR1
Description: Dihydrofolate reductase
Browser: contigD:1451709-1452396-
RNA-seq: read pairs 492, FPKM 26.5, percentile rank 49.3% (100% = highest expression)
Protein function
Annotation: | DFR1 | Dihydrofolate reductase | |
---|---|---|---|
KEGG: | K00287 | folA | dihydrofolate reductase [EC:1.5.1.3] |
EGGNOG: | 0PPTW | DFR1 | dihydrofolate reductase |
SGD closest match: | S000005762 | DFR1 | Dihydrofolate reductase |
CGD closest match: | CAL0000177250 | DFR1 | Dihydrofolate reductase |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
A0A167FPM6_9ASCO | 43.36% | 226 | 2e-55 | Dihydrofolate reductase OS=Sugiyamaella lignohabitans GN=DFR1 PE=3 SV=1 |
UniRef50_A0A167FPM6 | 43.36% | 226 | 5e-52 | Dihydrofolate reductase n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167FPM6_9ASCO |
A0A060T4G3_BLAAD | 41.36% | 220 | 1e-51 | ARAD1A17072p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A17072g PE=3 SV=1 |
A0A1E3PD95_9ASCO | 39.33% | 239 | 3e-51 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53532 PE=3 SV=1 |
Q6CC38_YARLI | 40.72% | 221 | 7e-48 | YALI0C12771p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C12771g PE=3 SV=1 |
A0A0J9XJB7_GEOCN | 36.52% | 230 | 2e-38 | Similar to Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase OS=Geotrichum candidum GN=BN980_GECA18s02342g PE=3 SV=1 |
DYR_YEAST | 35.74% | 235 | 1e-32 | Dihydrofolate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DFR1 PE=1 SV=2 |
Q5A5E0_CANAL | 33.62% | 229 | 7e-33 | Dihydrofolate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DFR1 PE=3 SV=1 |
A0A1E4TIE2_9ASCO | 35.62% | 219 | 6e-32 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_18002 PE=3 SV=1 |
MIA_04403_1 | 34.17% | 120 | 2e-14 | MIA_04403_1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.8737
Predicted cleavage: 69
Protein family membership
- Dihydrofolate reductase (IPR012259)
Domains and repeats
-
Domain
1
50
100
150
200
228
Detailed signature matches
no IPR
Unintegrated signatures
-
NON_CYTOPLASM... (N...)
-
SIGNAL_PEPTIDE (Sig...)
-
SIGNAL_PEPTID... (S...)
-
SIGNAL_PEPTID... (S...)
-
SIGNAL_PEPTID... (S...)
-
Residue annotation
-
folate binding sit...
-
NADP+ binding site...
Protein sequence
>MCA_05491_1 MAATKKPVSLILAAAVPSMGIGLNGTLPWNLSKEMAYFRQVTTKSVVIMGKTTWESIPLKFRPLKNRVNVVISSTLYKDN SDIYKDDQALNIKNSPVLYYKNFDTALNHIDKLYSDLPIYVIGGVQLYTSVLDHERVKNVLLTEVKKISVSPEDSSQYDT IECDSFFTAFPWYPKNTDEISINQKEWIRQSFDSLKAFVPEAISLENKPISENGFEYEFTLWNRNQQN
GO term prediction
Biological Process
GO:0006545 glycine biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0050661 NADP binding
Cellular Component
None predicted.