Protein

MCA_05470_1

Length
826 amino acids

Gene name: SPB1

Description: 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase

Browser: contigD:1400294-1402851-

RNA-seq: read pairs 1888, FPKM 28.2, percentile rank 50.9% (100% = highest expression)

Protein function

Annotation:SPB127S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase
KEGG:K14857SPB1 AdoMet-dependent rRNA methyltransferase SPB1 [EC:2.1.1.-]
EGGNOG:0PIINSPB1rRNA methyltransferase spb1
SGD closest match:S000000559SPB127S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase
CGD closest match:CAL0000201177SPB1AdoMet-dependent rRNA methyltransferase SPB1

Protein alignments

%idAln lengthE-value
MIA_05852_165.93%8540.0MIA_05852_1
A0A0J9X5H0_GEOCN57.16%8450.0AdoMet-dependent rRNA methyltransferase SPB1 OS=Geotrichum candidum GN=SPB1 PE=3 SV=1
A0A167CBA4_9ASCO56.99%8510.0AdoMet-dependent rRNA methyltransferase SPB1 OS=Sugiyamaella lignohabitans GN=SPB1 PE=3 SV=1
UniRef50_A0A167CBA456.99%8510.0AdoMet-dependent rRNA methyltransferase SPB1 n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A167CBA4_9ASCO
A0A1E3PRG9_9ASCO57.33%8250.0AdoMet-dependent rRNA methyltransferase SPB1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=SPB1 PE=3 SV=1
A0A060TAL0_BLAAD54.05%8640.0AdoMet-dependent rRNA methyltransferase SPB1 OS=Blastobotrys adeninivorans GN=SPB1 PE=3 SV=1
SPB1_YEAST52.35%8500.027S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPB1 PE=1 SV=2
SPB1_YARLI61.33%4815e-171AdoMet-dependent rRNA methyltransferase SPB1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SPB1 PE=3 SV=1
SPB1_CANAL58.58%5362e-168AdoMet-dependent rRNA methyltransferase SPB1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPB1 PE=3 SV=1
A0A1E4TBK1_9ASCO53.69%4342e-144Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15225 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0368

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 826

Detailed signature matches

  1. Family IPR015507
    Ribosomal RNA large subunit methyltransferase E
    1. MF_01547 (RNA_methy...)
  2. Family IPR028589
    AdoMet-dependent rRNA methyltransferase, Spb1
    1. MF_03163 (RNA_methy...)
  3. Domain IPR029063
    S-adenosyl-L-methionine-dependent methyltransferase
    1. SSF53335 (S-adenosy...)
  4. Domain IPR002877
    Ribosomal RNA methyltransferase FtsJ domain
    1. PF01728 (FtsJ)
  5. Domain IPR024576
    Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381
    1. PF11861 (DUF3381)
  6. Domain IPR012920
    Ribosomal RNA methyltransferase, Spb1, C-terminal
    1. PF07780 (Spb1_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. mobidb-lite (disord...)

Protein sequence

>MCA_05470_1
MGKAQKKHGKGRLDKYYRMAKEKGYRARSSFKIIHINEKFGHFLEKSKVVIDLCAAPGSWCQVASERCPVNSLIIGVDLD
RIKPLPNVITFQSDITTEHCRSELRSIMKTWKADTVLHDGAPNVGKDWIQDAFTQSDLVLKSLKLAVEFLAQGGIFVTKV
FRSKDYTKLMWIFQQFFESVEATKPPSSRNVSAEIFVVCKRFKAPKKYDPKLLDPRYVFEEVDQVNNQSLEKILNPEQKK
RKRDGYEEGDYTQHHECSVMELIKSNDPIQILGSYNALVLDKKDPELKPVRHLELTTDELLECFKDLKVLGRREFRMILK
WRKAARAVLNLDGESESKPEDEDKEEEELDEETKIDLELDALKDKERRRHKREKRRLNEKKQKEIIRMQMDMVSDMRIGT
ETNDDGKSLFNLTSAEKSGKLNSILKGKFIPSEERDDLEVSIPEPTVEYDDRSEEEIIDDMEAEMDAMYEEFKERQAEKK
ASYKSKKARDTTGYHDEWYGMGDEDEDNSEQDKISAANAEDSDDDFTSDDEDYQANAITSLLPKTTSTGLSTKAAMFFDN
SLFRDVDLNANDVKDITKTKKQAVPNTVEINSNVNDTPGSVENDEESEDEDEFASSEDDEDGNKDWNEDEEDEGPAVPDI
VTPQAMTIAHDLALGNINKHRLVDEGFNRFAFRDTEGLPEWFLEDEQKHNRVLKPVTKEAAEAVKAKLKALNARPIKKVA
EAKARKQMRRIKRLEKLRKKTELINEDVALSERDKADEIQKLTKKYSMTGGKKKKEKPRVTVVVARGNNRGIQGRPRGVK
GRYKMVDGVAKKEQRALKRISKKRKK

GO term prediction

Biological Process

GO:0001510 RNA methylation
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation

Molecular Function

GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity

Cellular Component

GO:0005634 nucleus