Protein

MCA_05469_1

Length
862 amino acids

Gene name: UBP10

Description: Ubiquitin carboxyl-terminal hydrolase 10

Browser: contigD:1397115-1399704-

RNA-seq: read pairs 723, FPKM 10.4, percentile rank 26.5% (100% = highest expression)

Protein function

Annotation:UBP10Ubiquitin carboxyl-terminal hydrolase 10
KEGG:K11873UBP10 ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
EGGNOG:0PIZRubiquitin carboxyl-terminal hydrolase
SGD closest match:S000005130UBP10Ubiquitin carboxyl-terminal hydrolase 10
CGD closest match:CAL0000187993DOT4Ubiquitin-specific protease

Protein alignments

%idAln lengthE-value
MIA_05851_162.98%3892e-172MIA_05851_1
A0A060TA42_BLAAD45.75%3651e-109ARAD1D20394p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D20394g PE=3 SV=1
UniRef50_A0A060TA4245.75%3653e-106ARAD1D20394p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060TA42_BLAAD
A0A0J9X489_GEOCN45.30%3626e-106Similar to Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties OS=Geotrichum candidum GN=BN980_GECA02s04536g PE=3 SV=1
A0A167CB96_9ASCO42.07%4164e-97Ubp10p OS=Sugiyamaella lignohabitans GN=UBP10 PE=3 SV=1
A0A1E3PFP8_9ASCO45.88%3642e-99Cysteine proteinase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_12288 PE=4 SV=1
UBP10_YEAST37.25%4516e-83Ubiquitin carboxyl-terminal hydrolase 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP10 PE=1 SV=2
Q6C7Z0_YARLI40.50%3633e-84YALI0D24211p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D24211g PE=3 SV=1
A0A1D8PLU4_CANAL42.29%4029e-81Ubiquitin-specific protease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DOT4 PE=3 SV=1
A0A1E4TC85_9ASCO30.92%3462e-46Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_138945 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2283
Predicted cleavage: 40

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 862

Detailed signature matches

  1. Domain IPR028889
    Ubiquitin specific protease domain
    1. PS50235 (USP_3)
  2. Domain IPR001394
    Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    1. PF00443 (UCH)
  3. SITE IPR018200
    Ubiquitin specific protease, conserved site
    1. PS00973 (USP_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.90.70.10
  3. SSF54001 (Cysteine ...)
  4. cd02257 (Peptidase_C19)
  5. mobidb-lite (disord...)

Residue annotation

  1. Active Site cd02257

Protein sequence

>MCA_05469_1
MSAPVAVFQKQSSTIIDQLKKSPLNFVAAKRPEAVSTRPTSYIHIKPASDTIDQDSNSDTEEKDFKVRSSSGQDQNQSIS
AEPKKQQSPNSASTKDSDSDSDSDYEDAINFNLSSDDNSVHESNSSNSEDENDDDNDENYQDDEETDNDDESDEQQFTQQ
TLKSIKGPLSLESLKLKQATILQNNKDISSSGDENSNSEPEEEKTASSSEIKQEPPQQTKNEAIKESSKKDDSEITQFMT
RGEKLQWRLKNEKELTDEVNSKYNFVGINSDNNSRSSHLNRRIRKTFPPGMQNPSGLMNNGVTCYMNSAIQSLFHLPAMC
NYLQDVFNGKYQDSISSRSVTRDLAHLFHRMTSPNAKFKNKRHSYDSSVNNRAILPTAIIRRLDDINPLMSEWNQEDSHE
YLMSLIGRLQEDSVPKGKKLNSSILYDMFGGTFLQTVICQECKNKSETHQDFFDIQVSIDKEELDVTGKATLNGSIRQYF
SNSFIKKSKTDGYDCEKCHKKTNALTYQRIERAPEYLVISIKRFEYTGKHSYSQKIKQNMAVSKVVELTPFSWKNTPMKY
ELMAFTVHEGRSASSGHYVAYCRQQDNTWALYDDELVERVPISRLNKTSKDDIYFLIYSKVDAVPLSEEKGILSDSLLKQ
RSLDRLANIDGNKQPAMPAEKPKTSDSFLPVESVTKPTNIMVSKKKSKKKLSLDSASRFSILDDDENDFGSQLKRSSSME
DYNNKIQAGLANTFNGKSQFLYDKKKNLAESKKYGKKSSHSISGRLGAFQPTNTLQKSISMPTLSSDNEERMNDKGSSKS
SIFKLAHKMMQKSKKPSSKDDSSKGKGHKRLTSQLSDSSLRSIARGNGEKVSKDKHKKKKHA

GO term prediction

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination

Molecular Function

GO:0036459 thiol-dependent ubiquitinyl hydrolase activity

Cellular Component

None predicted.