Protein

MCA_05431_1

Length
1,052 amino acids

Gene name: VPS11

Description: Tethering complex subunit

Browser: contigD:1312105-1315394+

RNA-seq: read pairs 1890, FPKM 22.2, percentile rank 44.1% (100% = highest expression)

Protein function

Annotation:VPS11Tethering complex subunit
KEGG:K20179VPS11 vacuolar protein sorting-associated protein 11
EGGNOG:0PI91FGSG_01612vacuolar protein sorting protein
SGD closest match:S000004844PEP5E3 ubiquitin-protein ligase PEP5
CGD closest match:CAL0000200561VPS11Tethering complex subunit

Protein alignments

%idAln lengthE-value
MIA_04208_172.11%9860.0MIA_04208_1
A0A0J9YH84_GEOCN64.58%9910.0Similar to Saccharomyces cerevisiae YMR231W PEP5 Component of CORVET tethering complex OS=Geotrichum candidum GN=BN980_GECA01s00725g PE=4 SV=1
A0A060T7V4_BLAAD52.44%9820.0ARAD1B23100p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B23100g PE=4 SV=1
A0A167C3E8_9ASCO52.13%9630.0Tethering complex subunit PEP5 OS=Sugiyamaella lignohabitans GN=PEP5 PE=4 SV=1
UniRef50_A0A167C3E852.13%9630.0Tethering complex subunit PEP5 n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A167C3E8_9ASCO
A0A1E3PLU6_9ASCO46.67%9900.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69604 PE=4 SV=1
Q6C4V4_YARLI44.50%10000.0YALI0E23408p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E23408g PE=4 SV=1
A0A1E4TLA2_9ASCO33.70%10000.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_88871 PE=4 SV=1
A0A1D8PMF6_CANAL34.12%10990.0Tethering complex subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=VPS11 PE=4 SV=1
PEP5_YEAST32.42%10582e-160E3 ubiquitin-protein ligase PEP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEP5 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2019
Predicted cleavage: 17

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
1 100 200 300 400 500 600 700 800 900 1000 1052

Detailed signature matches

  1. Family IPR016528
    Vacuolar protein sorting-associated protein 11
    1. PIRSF007860 (Vps11)
  2. Domain IPR011042
    Six-bladed beta-propeller, TolB-like
    1. G3DSA:2.120.1...
  3. Domain IPR017986
    WD40-repeat-containing domain
    1. SSF50978 (WD40 repe...)
  4. Domain IPR011990
    Tetratricopeptide-like helical domain
    1. G3DSA:1.25.40.10
  5. Domain IPR013083
    Zinc finger, RING/FYVE/PHD-type
    1. G3DSA:3.30.40.10
  6. Domain IPR001841
    Zinc finger, RING-type
    1. SM00184 (ring_2)
    2. PS50089 (ZF_RING_2)
  7. Domain IPR024763
    Vacuolar protein sorting protein 11, C-terminal
    1. PF12451 (VPS11_C)
  8. Repeat IPR000547
    Clathrin, heavy chain/VPS, 7-fold repeat
    1. PS50236 (CHCR)
    2. PF00637 (Clathrin)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SSF57850 (RING/U-box)
  3. SignalP-noTM
  4. cd16688 (RING-H2_Vps11)
  5. mobidb-lite (disord...)

Residue annotation

  1. Zn binding site cd...

Protein sequence

>MCA_05431_1
MFIFIHFWLQLSLTRYDGAVVVTSSGIAPNVTVMSCHLFPQCLPSNLNSNDGLAITKDFFYQFLVYFLNNILVLYNMALT
NWRYFNFFDTTPLKDPSLADASSLYSDPGLTSITPGNKTIFFATSNATIKEFDQDLRLKQSWAAYEPSVRITYLRYLKGT
SLLLSIGELQGSAGPIIKLWNLDKLDKKTHEPHCHSIVTVSNGDGIFPISAFDISPDYSTVALGFTDGAVILVRGDIVHD
RGSRQRVVYNSSGPITGLALHSDADGTLTLFVATVNRILTVPTTGKNNGKPEKILEKSKGADLGCTCYDSTNKMFVVARS
DSVSFYTTTGRGPSFVFDIPKKRVFTYKQYTIIVSSPEIPSPGENDGPHTNLSDILGGVGEMYSTYRLLIVDSKNQYIAY
SGQIPQGIVNIFVQWDKVMVLGADGVLYQFEEKSLEERLEILTQRNLYDVAIQLGKSLDIKKEKILRIEKDFGDYLYANG
EVADALPHYIEAIDLGGTSQIILKYRESQYINYLTTYLEALHEKGVALKEHTTLLLNSYAKLKDSKKLQDFIENDNNSGK
FDFETAIQICRQSGYFDMASHLAKKIGDSQLVVQIKLKDLEDYKGALSYVRSLPVDDCLRILIHNSRILLNKFPNDTTQL
LIELFTGKYVPKDEKEEETSLTEKESDSQIDSYISAPVLQSYRAFVNYMSTSTANSTDNLPNTTETTAPKPTYQPPRPRL
IFSSFVDHPNEFVIFLEACLEAYEEYSGNKKDKKDLLSTLFEMYLVLSRNADIPEVKKEWEEKAKNLAVESKDSLDPNTI
LLLSHMANFSEGQITMQDQDGFQIDLFRSCAATGDVRGAIKVLRQYGDEEPELYPLALTFFTSSPSTLKEAGDEFNFVLN
KIRDEKLMAPLQVVQALSVNSVATVGLVKDYLINIIQREKNEIDNNVKLSQSYRQETEAKKAEIEKLANDPMVIQYATCS
GCKSGLDLPAVHFACKHSFHQRCLHAADDLNPTCPVCLPNIEAISAIRKGQDDTGDRYDLFKIALEGSDSKFKVVTDFFG
RGAMEQARYILR

GO term prediction

Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.