Protein

MCA_05403_1

Length
154 amino acids

Gene name: FIS1

Description: Mitochondrial protein involved in fission; Saccharomyces cerevisiae homologue is involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division

Browser: contigD:1239204-1239821-

RNA-seq: read pairs 2616, FPKM 208.5, percentile rank 88.5% (100% = highest expression)

Protein function

Annotation:FIS1Mitochondrial protein involved in fission; Saccharomyces cerevisiae homologue is involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division
KEGG:K17969FIS1 mitochondrial fission 1 protein
EGGNOG:0PMVKFIS1Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity)
SGD closest match:S000001327FIS1Mitochondrial fission 1 protein
CGD closest match:CAL0000185855FIS1Mitochondrial fission 1 protein

Protein alignments

%idAln lengthE-value
MIA_00281_182.39%1591e-78MIA_00281_1
A0A0J9X7R9_GEOCN71.14%1491e-67Mitochondrial fission 1 protein OS=Geotrichum candidum GN=BN980_GECA04s07017g PE=3 SV=1
A0A060TDS1_BLAAD68.33%1203e-57Mitochondrial fission 1 protein OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D02398g PE=3 SV=1
FIS1_YARLI58.59%1283e-52Mitochondrial fission 1 protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=FIS1 PE=3 SV=2
A0A1E3PIT6_9ASCO57.03%1283e-50Mitochondrial fission 1 protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47023 PE=3 SV=1
UniRef50_Q7S8M156.10%1232e-43Mitochondrial fission 1 protein n=227 Tax=Fungi TaxID=4751 RepID=FIS1_NEUCR
FIS1_YEAST47.10%1552e-43Mitochondrial fission 1 protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FIS1 PE=1 SV=1
FIS1_CANAL46.03%1261e-36Mitochondrial fission 1 protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=FIS1 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0042

Protein family membership

Domains and repeats

  1. Domain
  2. Repeat
1 20 40 60 80 100 120 140 154

Detailed signature matches

  1. Family IPR016543
    Mitochondria fission 1 protein
    1. PIRSF008835 (TPR_re...)
  2. Domain IPR011990
    Tetratricopeptide-like helical domain
    1. G3DSA:1.25.40.10
    2. SSF48452 (TPR-like)
  3. Domain IPR033745
    Mitochondria fission protein Fis1, cytosolic domain
    1. cd12212 (Fis1)
  4. Repeat IPR028058
    Fis1, N-terminal tetratricopeptide repeat
    1. PF14852 (Fis1_TPR_N)
  5. Repeat IPR028061
    Fis1, C-terminal tetratricopeptide repeat
    1. PF14853 (Fis1_TPR_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)

Residue annotation

  1. heterodimer interf...

Protein sequence

>MCA_05403_1
MTEKFQLPSVQEINTPISKEELEVLRHQYYSEGQFVSLQTRFNYAWGLVRSPIVSDQQFGVKMLTDLFKDSPERRREVLY
YLSIGCYKLQDYSNARKYADILLELEPENRQVAQLRQVIEDRLAKEGLIGIAIASSVIAAVAAGVTFFVRNNRR

GO term prediction

Biological Process

GO:0000266 mitochondrial fission

Molecular Function

GO:0005515 protein binding

Cellular Component

None predicted.