MCA_05402_1

Protein

Length

490 amino acids

Description: Protein with NAD(P)-binding domains

RNA-seq: read pairs 56, FPKM 1.4, percentile rank 10.3% (100% = highest expression)

Protein function

Annotation:			Protein with NAD(P)-binding domains
EGGNOG:	0PKFE	FG08511.1	d-arabinitol
SGD closest match:	S000005146	SPS19	Peroxisomal 2,4-dienoyl-CoA reductase SPS19
CGD closest match:	CAL0000174204	ARD	Ardp

Protein alignments

	%id	Aln length	E-value
A0A0J9XIE3_GEOCN	67.12%	146	4e-59	Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA18s02144g PE=4 SV=1
UniRef50_A0A0J9XE82	64.38%	146	5e-54	Uncharacterized protein n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XE82_GEOCN
MIA_03478_1	61.07%	149	4e-54	MIA_03478_1
Q6C367_YARLI	69.84%	126	3e-52	YALI0F02211p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02211g PE=3 SV=1
A0A167BXQ3_9ASCO	68.80%	125	4e-52	Sps19p OS=Sugiyamaella lignohabitans GN=SPS19 PE=4 SV=1
A0A1E3PQI7_9ASCO	56.33%	158	8e-52	NAD(P)-binding protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50100 PE=4 SV=1
A0A060T1S4_BLAAD	68.80%	125	4e-51	ARAD1C18392p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C18392g PE=4 SV=1
A0A1D8PPB1_CANAL	61.60%	125	5e-44	Ardp OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ARD PE=4 SV=1
A0A1E4TBX3_9ASCO	54.76%	126	2e-38	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_29448 PE=4 SV=1
SPS19_YEAST	34.65%	127	5e-12	Peroxisomal 2,4-dienoyl-CoA reductase SPS19 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPS19 PE=1 SV=4

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9779
Predicted cleavage: 47

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
6 - 53
NAD(P)-binding domain (IPR016040)
112 - 205
NAD(P)-binding domain (IPR016040)
362 - 489
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 400 450 490

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  126 - 204
  
  Pfam
  PF00106 (adh_short)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  112 - 205
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  6 - 53
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  362 - 489
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  373 - 401
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

2 - 488

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
NON_CYTOPLASM... (N...)

25 - 490

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
PF13561 (adh_short_C2)

352 - 488

Pfam
PF13561 (adh_short_C2)
SIGNAL_PEPTIDE (Sig...)

1 - 24

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

17 - 24

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

6 - 16

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 5

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
mobidb-lite (disord...)

250 - 335

MobiDB Lite
mobidb-lite (disorder_prediction)

84 - 123

MobiDB Lite
mobidb-lite (disorder_prediction)

Protein sequence

>MCA_05402_1
MISKNLFSLTGKTVVVTGASGGLANAVCKAIVRAGARNIALIDYPQPAPSSSVMLEAALRPIVEQMYNQYDRIIKAQKKL
QQTKTNRISEVKNDKDPAKSKTGGTISSNGTKPNEIPEGPKPTPLTVSTWLCDISDQATVSKTMKAIKAYHNDTPLSVLI
NTAGYCENISAVDYPEKQLKRLLDVNLAGSMIVATEFAKAVIEQNPLQDKDKEQSPVPKQEKKIAEFINENLESSSSISS
STLENVNGTVTNAEQNQPRPLENNSSKVATENSGETSTNLNGESESSSHHKTNHAKEASPTVDANTSSEKPENNEGTSQP
TKECKNNGSPSAKNNASIKNAYLLPEIKSMELASQANTPLTTRASIILIASMSGSIVNYPQPQAAYNMSKAGVIHLAKSL
ASEWAPYGIRVNSLSPGYILTPLTKKIFEKRKGSKLDGIFDLKTQWEMKIPMGRMALPEEVAEPIVFMASDASSYMTGSD
LIIDGGYTVR

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component