Protein

MCA_05381_1

Length
529 amino acids

Gene name: ALD5A

Description: Aldehyde dehydrogenase 5, mitochondrial

Browser: contigD:1181522-1183112-

RNA-seq: read pairs 26187, FPKM 610.5, percentile rank 95.0% (100% = highest expression)

Protein function

Annotation:ALD5AAldehyde dehydrogenase 5, mitochondrial
KEGG:K00128ALDH aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
EGGNOG:0PFKNALD5Aldehyde dehydrogenase
SGD closest match:S000000875ALD5Aldehyde dehydrogenase 5, mitochondrial
CGD closest match:CAL0000188934ALD5Aldehyde dehydrogenase (NAD(P)(+))

Protein alignments

%idAln lengthE-value
MIA_03361_173.07%5310.0MIA_03361_1
A0A0J9XHI0_GEOCN68.32%5240.0Similar to Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase OS=Geotrichum candidum GN=BN980_GECA18s01209g PE=3 SV=1
A0A060T678_BLAAD65.49%4810.0ARAD1C17776p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C17776g PE=3 SV=1
A0A167DZ78_9ASCO65.77%4850.0Aldehyde dehydrogenase (NADP(+)) ALD4 OS=Sugiyamaella lignohabitans GN=ALD4 PE=3 SV=1
ALDH5_YEAST63.06%5170.0Aldehyde dehydrogenase 5, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALD5 PE=1 SV=4
A0A1E3PQ22_9ASCO66.11%4750.0Aldehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49830 PE=3 SV=1
UniRef50_A0A1X7R31161.96%5100.0Similar to Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase n=2 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7R311_9SACH
Q6C7J6_YARLI62.35%4860.0YALI0E00264p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E00264g PE=3 SV=1
A0A1D8PGT5_CANAL61.80%5000.0Aldehyde dehydrogenase (NAD(P)(+)) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ALD5 PE=3 SV=1
A0A1E4TLM3_9ASCO58.49%4890.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43149 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9959
Predicted cleavage: 33

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 529

Detailed signature matches

  1. Domain IPR016161
    Aldehyde/histidinol dehydrogenase
    1. SSF53720 (ALDH-like)
  2. Domain IPR016162
    Aldehyde dehydrogenase N-terminal domain
    1. G3DSA:3.40.60...
  3. Domain IPR015590
    Aldehyde dehydrogenase domain
    1. PF00171 (Aldedh)
  4. SITE IPR029510
    Aldehyde dehydrogenase, glutamic acid active site
    1. PS00687 (ALDEHYDE_D...)
  5. SITE IPR016160
    Aldehyde dehydrogenase, cysteine active site
    1. PS00070 (ALDEHYDE_D...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.30...
  3. cd07091 (ALDH_F1-2_...)

Residue annotation

  1. NAD(P) binding sit...
  2. catalytic residues...

Protein sequence

>MCA_05381_1
MNRTFTLASKALKSNVRFASPAMRSSAFIRFYSSAFPTSVKLTTPNGITYEQPTGLFINGEFIPSPSGKTITVESPSTES
KITEVHEATPEDVDAAVDAAEKAFESWSITPPSVRGRLLTKLADKIEEHADILASIESYDNGKALSSAKGDVALVANVLR
YYGGFADKIHGTTIETDDGHFTFTKREPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKTAEATPLSALYACKLAKE
VGIPDGVINNISGFGPTGAAIASHLKIKKVAFTGSTATGRFIMKAAAESNLKKVTLELGGKSPHIIFSDADLDNAVEVAA
AGIFFNSGEVCSAGSRLYVQDTIYDEFLARLKAKAESVKVGNPFDLETFQGSQTSKGHLQKILGYIDVGKQEGARVLTGG
ERLNRPGYYVAPTVFADVHPNMRISKEEIFGPILTATKFSTVDEVVKMANDSVYGLGAGIHTKDMNKIVDLSNRIKSGSV
WVNTYNAFHEAVPFGGFNQSGMGREMGEQGLDNYTQVKAVRMKVIPTNV

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.