Protein

MCA_05380_1

Length
541 amino acids

Gene name: ALD4A

Description: Potassium-activated aldehyde dehydrogenase, mitochondrial

Browser: contigD:1178642-1180268-

RNA-seq: read pairs 661, FPKM 15.1, percentile rank 34.2% (100% = highest expression)

Protein function

Annotation:ALD4APotassium-activated aldehyde dehydrogenase, mitochondrial
KEGG:K00128ALDH aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
EGGNOG:0PFKNALD5Aldehyde dehydrogenase
SGD closest match:S000005901ALD4Potassium-activated aldehyde dehydrogenase, mitochondrial
CGD closest match:CAL0000188934ALD5Aldehyde dehydrogenase (NAD(P)(+))

Protein alignments

%idAln lengthE-value
MIA_03361_170.08%4980.0MIA_03361_1
A0A0J9XHI0_GEOCN67.07%5010.0Similar to Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase OS=Geotrichum candidum GN=BN980_GECA18s01209g PE=3 SV=1
A0A1E3PQ22_9ASCO65.97%4760.0Aldehyde dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49830 PE=3 SV=1
UniRef50_J7R5Z362.83%4950.0Uncharacterized protein n=129 Tax=Eukaryota TaxID=2759 RepID=J7R5Z3_KAZNA
ALDH4_YEAST61.35%5020.0Potassium-activated aldehyde dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALD4 PE=1 SV=2
A0A060T678_BLAAD63.56%4830.0ARAD1C17776p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C17776g PE=3 SV=1
A0A167DZ78_9ASCO62.73%4830.0Aldehyde dehydrogenase (NADP(+)) ALD4 OS=Sugiyamaella lignohabitans GN=ALD4 PE=3 SV=1
Q6CD79_YARLI62.27%4850.0YALI0C03025p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C03025g PE=3 SV=1
A0A1D8PGT5_CANAL60.20%4900.0Aldehyde dehydrogenase (NAD(P)(+)) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ALD5 PE=3 SV=1
A0A1E4TLM3_9ASCO58.45%4910.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_43149 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9988
Predicted cleavage: 30

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 450 500 541

Detailed signature matches

  1. Domain IPR016161
    Aldehyde/histidinol dehydrogenase
    1. SSF53720 (ALDH-like)
  2. Domain IPR016162
    Aldehyde dehydrogenase N-terminal domain
    1. G3DSA:3.40.60...
  3. Domain IPR015590
    Aldehyde dehydrogenase domain
    1. PF00171 (Aldedh)
  4. SITE IPR029510
    Aldehyde dehydrogenase, glutamic acid active site
    1. PS00687 (ALDEHYDE_D...)
  5. SITE IPR016160
    Aldehyde dehydrogenase, cysteine active site
    1. PS00070 (ALDEHYDE_D...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.30...
  2. cd07091 (ALDH_F1-2_...)

Residue annotation

  1. NAD(P) binding sit...
  2. catalytic residues...

Protein sequence

>MCA_05380_1
MTRAFFTASRAIRSRPAAALLTRAAGTRQTVLPSLYSSFKYYSSASHPLSVPISLPNGIKYDQPTGLFINNEFVPSKSGE
LLSVESPSTEEHITQVYLARNPDVDVAVDAAEKAFKTWSTAQPSFRGDIMFRLADKIEENLELLASIEVLDNGKAISSAR
GDIALVAKVIRFYAGCADKNDGTLVDTNDGYFSYTKREPIGVCGQIIPWNFPLLMWAWKIAPALATGNTVVLKTAESTPL
SALVACELAKQVGLPPGVMNVISGAGETGAYIANHPKIRKIAFTGSTATGRYIMEAAAKSNLKKVTLELGGKSPHIVFND
ADLDKAAEIAAAAIFYNSGEVCCAGSRLYVQEDIYDKFIAKVADIAKNLKVGNPFDEATFQGSQTSKVQLERILKYIDIG
KSEGAQVVTGGTRLDSKGYFVAPTVFGNVNSSMKIVQEEIFGPVVVAEKFSTVQEVIDKANDSEYGLAAGVHTQDLNKAI
DISNKLHAGSVWVNSYNAFHEAVPFGGFNQSGMGREMGKQGLDNYTQVKAVRIKIEDTSKN

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.