Protein

MCA_05348_1

Length
650 amino acids

Gene name: MSK1

Description: mitochondrial lysine-tRNA synthetase; protein with OB-fold nucleic acid-binding domain

Browser: contigD:1079150-1081103+

RNA-seq: read pairs 848, FPKM 16.1, percentile rank 35.6% (100% = highest expression)

Protein function

Annotation:MSK1mitochondrial lysine-tRNA synthetase; protein with OB-fold nucleic acid-binding domain
KEGG:K04567KARS lysyl-tRNA synthetase, class II [EC:6.1.1.6]
EGGNOG:0PFJ1FG00875.1lysyl-tRNA synthetase
SGD closest match:S000005017MSK1Lysine--tRNA ligase, mitochondrial
CGD closest match:CAL0000184486MSK1Lysine--tRNA ligase

Protein alignments

%idAln lengthE-value
MIA_02483_149.50%5986e-168MIA_02483_1
A0A0J9XAZ4_GEOCN48.57%5934e-163Lysine--tRNA ligase OS=Geotrichum candidum GN=BN980_GECA07s04916g PE=4 SV=1
A0A060TA79_BLAAD44.17%6005e-129Lysine--tRNA ligase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D21472g PE=4 SV=1
UniRef50_A0A060TA7944.17%6001e-125Lysine--tRNA ligase n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A060TA79_BLAAD
A0A167FZ22_9ASCO45.82%5029e-125Lysine--tRNA ligase KRS1 OS=Sugiyamaella lignohabitans GN=KRS1 PE=4 SV=1
A0A1E3PPF6_9ASCO41.17%6007e-116Lysine--tRNA ligase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81709 PE=4 SV=1
Q6C814_YARLI39.39%5941e-115YALI0D23639p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23639g PE=4 SV=2
A0A1D8PQY7_CANAL36.16%5671e-95Lysine--tRNA ligase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MSK1 PE=4 SV=1
A0A1E4THC7_9ASCO33.87%5551e-71Lysine--tRNA ligase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_116458 PE=3 SV=1
SYKM_YEAST32.57%6113e-71Lysine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSK1 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9627
Predicted cleavage: 21

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 650

Detailed signature matches

  1. Domain IPR012340
    Nucleic acid-binding, OB-fold
    1. SSF50249 (Nucleic a...)
  2. Domain IPR004365
    OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
    1. PF01336 (tRNA_anti-...)
  3. Domain IPR006195
    Aminoacyl-tRNA synthetase, class II
    1. PS50862 (AA_TRNA_LI...)
  4. Domain IPR004364
    Aminoacyl-tRNA synthetase, class II (D/K/N)
    1. PF00152 (tRNA-synt_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:2.40.50...
  2. G3DSA:3.30.93...
  3. SSF55681 (Class II ...)
  4. cd04322 (LysRS_N)

Residue annotation

  1. dimer interface cd...
  2. putative anticodon...

Protein sequence

>MCA_05348_1
MIKHQRFCSKVFTSVVSARSRVSLTGSLSIASQWYSTTTSTTATNKEKNKSANASKRMSLVHENEALDFANRKANLLTKP
IDLYPSLSLPSFDSNITGYQAVRIPEFRSKYGPQLSGDEKSNGGDPLPDLITVQGRVSKIRKSGKGLLFYDLIQDSTKLQ
VVINQKKLVNSSFNKEEEEQTEQQNLIDIEKFINLHSYFRRGDIVSISGKPWKTPRGELSLLADHPATLLSPCFHPIPLK
ALNQDSAATKHNRVVNFLSSKEARYVIVMRSQILQYIRNFFFNKGFLEVQTPTLSNNATGATARPFLTELNFSGTQNSTS
DLVEVNEEKEKLKLALRIAPELWLKRLIVSGFDKIFEIGQCYRNEGLDTTHNPEFTSCEFYQSYTNLDGLVDITQTFLRG
LVDNLVEIAKKSRGDHSETAAAGTTTAFQNLVECPDPIFENLLQIQKAFSKDFIKLDFVKDIETATGKPLPKDLSDYDKV
LEYAKTVGAMSSSSSSSVPPPTLAKVLDNLAAKYLETQSQGHYTPVLIVNHPTEMSALAKSVENSGRTLSRRFELFINGK
EYINAYEEENSPVEQLKKFELQQQSSSSSSTVRDEETPLPDYSYVETLEWGLPPTGGWGLGIDRLCMLMSNSKSIEQVLS
FGSVKTVNYQ

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation

Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

None predicted.