Protein

MCA_05346_1

Length
287 amino acids


Gene name: MIA40

Description: Mitochondrial intermembrane space import and assembly protein 40

Browser: contigD:1075098-1075962+

RNA-seq: read pairs 3987, FPKM 171.1, percentile rank 86.3% (100% = highest expression)

Protein function

Annotation:MIA40Mitochondrial intermembrane space import and assembly protein 40
KEGG:K17782MIA40 mitochondrial intermembrane space import and assembly protein 40
EGGNOG:0PQPTMIA40Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS
SGD closest match:S000001678MIA40Mitochondrial intermembrane space import and assembly protein 40
CGD closest match:CAL0000191454MIA40Mitochondrial intermembrane space import and assembly protein 40

Protein alignments

%idAln lengthE-value
MIA_02509_169.31%1015e-46MIA_02509_1
UniRef50_W1QJX169.07%973e-40Mitochondrial intermembrane space import and assembly protein 40 n=2 Tax=Ogataea TaxID=461281 RepID=W1QJX1_OGAPD
A0A1E3PN12_9ASCO67.74%931e-40Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_41307 PE=4 SV=1
Q6C535_YARLI85.51%691e-41YALI0E21373p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E21373g PE=4 SV=1
A0A0J9XJE1_GEOCN85.07%674e-40Similar to Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space (IMS) OS=Geotrichum candidum GN=BN980_GECA19s00208g PE=4 SV=1
A0A1E4TD07_9ASCO84.06%692e-41Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32822 PE=4 SV=1
MIA40_YEAST74.12%855e-39Mitochondrial intermembrane space import and assembly protein 40 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MIA40 PE=1 SV=2
A0A161HMT3_9ASCO78.26%693e-39Mia40p OS=Sugiyamaella lignohabitans GN=MIA40 PE=4 SV=1
A0A060SYP7_BLAAD84.85%665e-39ARAD1A18656p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A18656g PE=4 SV=1
MIA40_CANAL72.06%682e-34Mitochondrial intermembrane space import and assembly protein 40 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MIA40 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9975
Predicted cleavage: 46

Protein family membership

None predicted.

Domains and repeats

None predicted.

Detailed signature matches

Unintegrated signatures no IPR
Unintegrated signatures
  1. PS51808 (CHCH)
  2. TRANSMEMBRANE (Tran...)
  3. mobidb-lite (disord...)

Protein sequence

>MCA_05346_1
MYRANTLRRLSAKSAGLRSVAGSLRSGSVSNVARFSTMPKTSARNSSSHLLVGGACAFTVGLIGYNSYFKSEKILLDDGK
IEKTAEPVMEEVVVIEESVKEDIPVITATIEETAEKLGSTIEEISEEIEKEVENIANEITEELAEAQALEEKAEEESAAQ
NKGAYDPETGEINWDCPCLGGMAHGPCGEEFKTAFSCFVYSKEEPKGIDCIEKFSAMQNCFREHPEVYAEELRETEPFPE
EDDKSKSAPSNEDVSAKPVEESKPAAEPVTEEVEPKKSKKSKKASKE

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.