Protein

MCA_05300_1

Length
491 amino acids

Gene name: LAG1A

Description: Sphingosine N-acyltransferase LAG1

Browser: contigD:940007-941483-

RNA-seq: read pairs 1980, FPKM 49.7, percentile rank 65.3% (100% = highest expression)

Protein function

Annotation:LAG1ASphingosine N-acyltransferase LAG1
KEGG:K04709LAG1 Acyl-CoA-dependent ceramide synthase [EC:2.3.1.24]
EGGNOG:0PHZ0FG05525.1Ceramide synthase
SGD closest match:S000000995LAG1Sphingosine N-acyltransferase LAG1
CGD closest match:CAL0000185837LAG1Sphingosine N-acyltransferase

Protein alignments

%idAln lengthE-value
MIA_04868_156.03%4735e-153MIA_04868_1
A0A0J9X9L5_GEOCN52.16%4622e-136Similar to Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component OS=Geotrichum candidum GN=BN980_GECA06s01231g PE=4 SV=1
A0A060T2S4_BLAAD49.67%4596e-136ARAD1C35134p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35134g PE=4 SV=1
Q6C2N3_YARLI47.05%4574e-131YALI0F06424p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F06424g PE=4 SV=1
UniRef50_Q6C2N347.05%4571e-127YALI0F06424p n=11 Tax=Ascomycota TaxID=4890 RepID=Q6C2N3_YARLI
A0A167DPT5_9ASCO57.97%3455e-126Sphingosine N-acyltransferase LAG1 OS=Sugiyamaella lignohabitans GN=LAG1 PE=4 SV=1
A0A1E3PGJ2_9ASCO54.39%3421e-114Longevity assurance proteins LAG1/LAC1 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52136 PE=4 SV=1
Q5A879_CANAL54.91%3462e-113Sphingosine N-acyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LAG1 PE=4 SV=1
A0A1E4TBG7_9ASCO60.67%2671e-105Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3737 PE=4 SV=1
LAG1_YEAST50.87%3464e-102Sphingosine N-acyltransferase LAG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAG1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1619

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 491

Detailed signature matches

  1. Family IPR016439
    Ceramide synthase component Lag1/Lac1
    1. PIRSF005225 (LAG1_LAC1)
  2. Domain IPR013599
    TRAM1-like protein
    1. PF08390 (TRAM1)
  3. Domain IPR006634
    TRAM/LAG1/CLN8 homology domain
    1. PS50922 (TLC)
    2. PF03798 (TRAM_LAG1_...)
    3. SM00724 (lag1_27)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. mobidb-lite (disord...)

Protein sequence

>MCA_05300_1
MSRRSSHVGHISLGDTAVPGLSTMPLDPKQERESRRRVRALSKSDSDYNRNNKDTKESSSSTDSAVTTGLDSSNNLINKR
NTISENDQNGNFKSSSSSISSSSSKRSSKSIGKLTPLSKFYYSYLEYSYRNSWLNPLICLLVIFTVCFLSPDKSPNGWTH
MFIHLSYEIPKEQLPISDVLSPETAPFGVFPMYGKGLRDFAFVFTGTIFFMFFREFVMQVLLNPLAKVCGLKRKSKISRF
MEQTYAIVYFGMSAPLGLYVMYITKDIEGNPLWYFETVAFYANYPHKIHGWLFKAFYLLQASFWTQQSVVLCLQLEKPRR
DFKELVFHHVVTIALIFCSYRFHFAFIGIAVFITMDFSDIFLSLSKTLNYLDSKFTPVMFIIFIGVWVYARHYLNLWILW
SVLTEFRTIGPYTLSFADEQYKCWISQVITFVLIFSLQLVNLYWLFLILRILYRLVTAGEQKDERSDDEDEDEDEENDEN
LTTTSNESDEK

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane