Protein

MCA_05234_1

Length
303 amino acids

Gene name: HIS1

Description: ATP phosphoribosyltransferase

Browser: contigD:702396-703366+

RNA-seq: read pairs 2620, FPKM 106.5, percentile rank 79.8% (100% = highest expression)

Protein function

Annotation:HIS1ATP phosphoribosyltransferase
KEGG:K00765hisG ATP phosphoribosyltransferase [EC:2.4.2.17]
EGGNOG:0PI50HIS1ATP phosphoribosyltransferase
SGD closest match:S000000857HIS1ATP phosphoribosyltransferase
CGD closest match:CAL0000180598HIS1ATP phosphoribosyltransferase

Protein alignments

%idAln lengthE-value
MIA_01960_180.45%3120.0MIA_01960_1
A0A0J9XAP9_GEOCN70.30%3031e-152Similar to Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase OS=Geotrichum candidum GN=BN980_GECA07s01352g PE=3 SV=1
A0A060TG19_BLAAD68.98%3033e-145ARAD1D27500p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D27500g PE=3 SV=1
A0A1E3PCP4_9ASCO67.66%3035e-143ATP phosphoribosyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84551 PE=3 SV=1
HIS1_YARLI67.66%3032e-142ATP phosphoribosyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HIS1 PE=3 SV=1
UniRef50_Q9914567.66%3034e-139ATP phosphoribosyltransferase n=47 Tax=Fungi TaxID=4751 RepID=HIS1_YARLI
HIS1_YEAST64.36%3031e-138ATP phosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS1 PE=1 SV=1
HIS1_CANAL62.90%3101e-131ATP phosphoribosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HIS1 PE=3 SV=1
A0A1E4TDI7_9ASCO59.43%3184e-126Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4441 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0356

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 303

Detailed signature matches

  1. Family IPR020621
    ATP phosphoribosyltransferase HisG, long form
    1. MF_00079 (HisG_Long)
  2. Domain IPR013820
    ATP phosphoribosyltransferase, catalytic domain
    1. TIGR00070
    2. PF01634 (HisG)
  3. Domain IPR015867
    Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal
    1. G3DSA:3.30.70...
  4. Domain IPR011322
    Nitrogen regulatory PII-like, alpha/beta
    1. SSF54913 (GlnB-like)
  5. Domain IPR013115
    Histidine biosynthesis HisG, C-terminal
    1. TIGR03455
    2. PF08029 (HisG_C)
  6. SITE IPR018198
    ATP phosphoribosyltransferase, conserved site
    1. PS01316 (ATP_P_PHOR...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.19...
  2. SSF53850 (Periplasm...)

Protein sequence

>MCA_05234_1
MDLVNHLNDRLLFAIPKKGRLNERTIQLLNGADIQFKRSHRLDIALSTNMPVALVFLPAADIPRFVAEGRCALGITGADQ
VSESGLDCDMLLDLSFGKCKLQVQVPENSEYEKPEQLIGKSIVTSFTKLTDEYFTKLEHGDSSSSQDKKSSTTIKYVGGS
VEAAVALGVADAIVDLVESGETMRAAGLKPIATLMNTSAWLIQNKRVSASDLEICNIIRSRLEGVLAASKYVLCNYNAPR
NHLPELLKITPGRRAPTITQLEEEEWVAVSSMVLQTEIASVMDRLKSNGAEDILVFQISNCRV

GO term prediction

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0000287 magnesium ion binding
GO:0003879 ATP phosphoribosyltransferase activity

Cellular Component

GO:0005737 cytoplasm