Protein

MCA_05189_1

Length
433 amino acids

Gene name: STR3

Description: Cystathionine beta-lyase

Browser: contigD:582519-583821+

RNA-seq: read pairs 3147, FPKM 89.6, percentile rank 77.1% (100% = highest expression)

Protein function

Annotation:STR3Cystathionine beta-lyase
KEGG:K01760metC cystathionine beta-lyase [EC:4.4.1.8]
EGGNOG:0PHQJSTR3cystathionine beta-lyase
SGD closest match:S000003152STR3Cystathionine beta-lyase
CGD closest match:CAL0000187862orf19.2092Cystathionine beta-lyase

Protein alignments

%idAln lengthE-value
MIA_01227_183.37%4330.0MIA_01227_1
A0A0J9X7M3_GEOCN79.08%3920.0Similar to Saccharomyces cerevisiae YGL184C STR3 Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine OS=Geotrichum candidum GN=BN980_GECA04s04773g PE=3 SV=1
A0A1E3PEX0_9ASCO73.97%4110.0Cystathionine beta-lyase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48079 PE=3 SV=1
Q6CAR4_YARLI74.43%3950.0YALI0D00605p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D00605g PE=3 SV=1
A0A060T3A5_BLAAD73.72%3920.0ARAD1C31218p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C31218g PE=3 SV=1
A0A167DB85_9ASCO76.80%3750.0Cystathionine beta-lyase STR3 OS=Sugiyamaella lignohabitans GN=STR3 PE=3 SV=1
UniRef50_W6QAK271.68%3920.0Cystathionine beta-lyase n=41 Tax=leotiomyceta TaxID=716546 RepID=W6QAK2_PENRF
Q5ACX5_CANAL67.45%3840.0Cystathionine beta-lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.2092 PE=3 SV=1
A0A1E4TGX8_9ASCO68.37%3920.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31814 PE=3 SV=1
STR3_YEAST50.50%4001e-127Cystathionine beta-lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STR3 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0678

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 433

Detailed signature matches

  1. Family IPR000277
    Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
    1. cd00614 (CGS_like)
    2. PIRSF001434 (CGS)
    3. PS00868 (CYS_MET_ME...)
    4. PF01053 (Cys_Met_Me...)
  2. Family IPR006238
    Cystathionine beta-lyase, eukaryotic
    1. TIGR01329
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  5. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Residue annotation

  1. homodimer interfac...
  2. pyridoxal 5'-phosp...
  3. substrate-cofactor...
  4. catalytic residue ...

Protein sequence

>MCA_05189_1
MSTPNDTTLANLSLHLSDPSARGEGFPPPSPAPSSPRSRRHYSIETELVYTETTDQYGSSSAPIYQTATFKQESLSNMGE
YDYTRSGNPTRTHLERHLAKIIGGAARCLTVTSGMTALDVITRLLKPGDEVIAGDDLYGGTNRLLKYLSTKGGVITHHVD
TTNVDAVKAKVSSKTAMVLLESPTNPLIKIANIPEIAKHVHKINPDSLVIVDNTMLSPLLMAPLELGADIVYESGTKYLS
GHHDIMAGVIACKDEKIANDIFFVINASGCGLAPFESWLLERGIKTLGVRMEKQQSNAQQIAEFLEGCGFKVRYPGLKSH
PQYDLHWSQASGAGAVLSLETGDIKLSEAIIEGTRIWGISVSFGCVNSLISMPCKMSHASIDAKTRAERDFPEDLIRLCV
GIENPTDLINDLKTSLVKAGAVKLNSDGSITKI

GO term prediction

Biological Process

GO:0071266 'de novo' L-methionine biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004121 cystathionine beta-lyase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

None predicted.