Protein

MCA_05147_1

Length
448 amino acids

Gene name: INT6

Description: Eukaryotic translation initiation factor 3 subunit E

Browser: contigD:466854-468201+

RNA-seq: read pairs 9501, FPKM 261.5, percentile rank 90.8% (100% = highest expression)

Protein function

Annotation:INT6Eukaryotic translation initiation factor 3 subunit E
KEGG:K03250EIF3E translation initiation factor 3 subunit E
EGGNOG:0PISDINT6Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity)

Protein alignments

%idAln lengthE-value
MIA_06092_171.27%4420.0MIA_06092_1
A0A0J9X3J2_GEOCN64.63%4410.0Eukaryotic translation initiation factor 3 subunit E OS=Geotrichum candidum GN=INT6 PE=3 SV=1
UniRef50_A0A0J9X3J264.63%4410.0Eukaryotic translation initiation factor 3 subunit E n=18 Tax=Fungi TaxID=4751 RepID=A0A0J9X3J2_GEOCN
A0A060T492_BLAAD59.82%4330.0Eukaryotic translation initiation factor 3 subunit E OS=Blastobotrys adeninivorans GN=INT6 PE=3 SV=1
A0A167FIQ2_9ASCO59.68%4440.0Eukaryotic translation initiation factor 3 subunit E OS=Sugiyamaella lignohabitans GN=INT6 PE=3 SV=1
A0A1E3PJ91_9ASCO52.85%4396e-174Eukaryotic translation initiation factor 3 subunit E OS=Nadsonia fulvescens var. elongata DSM 6958 GN=INT6 PE=3 SV=1
EIF3E_YARLI53.77%4241e-161Eukaryotic translation initiation factor 3 subunit E OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=INT6 PE=3 SV=1
A0A1E4TI80_9ASCO39.12%4321e-101Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_15354 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0640

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 448

Detailed signature matches

  1. Family IPR016650
    Eukaryotic translation initiation factor 3 subunit E
    1. PIRSF016255 (Transl...)
    2. MF_03004 (eIF3e)
  2. Domain IPR019010
    Eukaryotic translation initiation factor 3 subunit E, N-terminal
    1. SM01186 (eIF3_N_2)
    2. PF09440 (eIF3_N)
  3. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. G3DSA:1.10.10.10
    2. SSF46785 ("Winged h...)
  4. Domain IPR000717
    Proteasome component (PCI) domain
    1. SM00088 (PINT_4)
    2. PF01399 (PCI)
Unintegrated signatures no IPR
Unintegrated signatures
  1. SM00753 (PINT)

Protein sequence

>MCA_05147_1
MSQQEVTTKQSEKALELARKYDLTETLMPFLDRHLIFPIASFLSKRGIYDSQSILELNYNLFKDSYMVDFVQELWQQLHE
GEEPPAEFDERRKINAEKVAKYEQDIAIVSQAFENPEVQANLKEDKVANLRMLEKYGVTVDIINSLYHFGQFKFSCGEYE
AASRTLTQFQLLSTDTALNLSATWGQFACDLLNDDMSSALEKQQILREAIDQRSVSNPLTQLHNRTWIIHWSLFLFPNRN
FNKDGLVDLLFSPSYISTIQAACPWIIRYIAAAVIASNSKGRNSTSAQKRLKELIKVVGQELYEYEDPITDFVRALYIDY
DFAEAQSKLSEAEIILSNDFFLCDMTEAFLDSARHLVSELYCRIHQRIDVKQLSLRLNLDPEQGEKWIANLIKDTKMDAK
INESDGTVIMNHHITSVYQQVIEKTRGLTFRSNQILNQAVNKNDSVIA

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003743 translation initiation factor activity
GO:0005515 protein binding

Cellular Component

GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex