MCA_04953_1

Protein

Length

913 amino acids

Gene name: PKH2

Description: Serine/threonine protein kinase; in S. cerevisiae involved in sphingolipid-mediated signaling pathway that controls endocytosis

Browser: contigC:4507634-4510461+

RNA-seq: read pairs 5734, FPKM 77.5, percentile rank 74.7% (100% = highest expression)

Protein function

Annotation:		PKH2	Serine/threonine protein kinase; in S. cerevisiae involved in sphingolipid-mediated signaling pathway that controls endocytosis
KEGG:	K06276	PDPK1	3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
EGGNOG:	0PGTT	PKH3	serine threonine protein kinase
SGD closest match:	S000005460	PKH2	Serine/threonine-protein kinase PKH2
CGD closest match:	CAL0000187991	PKH2	Serine/threonine-protein kinase PKH2

Protein alignments

	%id	Aln length	E-value
MIA_04259_1	64.32%	398	0.0	MIA_04259_1
A0A167C8X5_9ASCO	68.04%	341	3e-165	Serine/threonine protein kinase PKH2 OS=Sugiyamaella lignohabitans GN=PKH2 PE=4 SV=1
UniRef50_A0A167C8X5	68.04%	341	7e-162	Serine/threonine protein kinase PKH2 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167C8X5_9ASCO
A0A1E3PGW1_9ASCO	65.77%	336	1e-159	Kinase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83515 PE=4 SV=1
A0A0J9X399_GEOCN	67.91%	321	6e-163	Similar to Saccharomyces cerevisiae YDR490C PKH1 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis OS=Geotrichum candidum GN=BN980_GECA01s10020g PE=4 SV=1
Q6CFM7_YARLI	66.28%	341	3e-154	YALI0B05566p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B05566g PE=4 SV=1
A0A060SYZ5_BLAAD	64.22%	327	2e-150	ARAD1C01276p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01276g PE=4 SV=1
PKH2_CANAL	55.30%	349	1e-130	Serine/threonine-protein kinase PKH2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PKH2 PE=1 SV=2
A0A1E4TEU0_9ASCO	63.61%	294	1e-130	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31248 PE=4 SV=1
PKH2_YEAST	50.31%	320	2e-109	Serine/threonine-protein kinase PKH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKH2 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1016

Protein family membership

None predicted.

Domains and repeats

Domain
164 - 491
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 100 200 300 400 500 600 700 800 913

Detailed signature matches

IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  164 - 491
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  166 - 432
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. PF00069 (Pkinase)
  
  166 - 432
  
  Pfam
  PF00069 (Pkinase)
3. SM00220 (serkin_6)
  
  166 - 432
  
  SMART
  SM00220 (serkin_6)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  172 - 195
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  286 - 298
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

G3DSA:1.10.51...

265 - 683

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:3.30.20...

94 - 264

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
NON_CYTOPLASM... (N...)

25 - 913

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
SIGNAL_PEPTIDE (Sig...)

1 - 24

PHOBIUS
SIGNAL_PEPTIDE (Signal Peptide)
SIGNAL_PEPTID... (S...)

17 - 24

PHOBIUS
SIGNAL_PEPTIDE_C_REGION (Signal peptide C-region)
SIGNAL_PEPTID... (S...)

6 - 16

PHOBIUS
SIGNAL_PEPTIDE_H_REGION (Signal peptide H-region)
SIGNAL_PEPTID... (S...)

1 - 5

PHOBIUS
SIGNAL_PEPTIDE_N_REGION (Signal peptide N-region)
cd05581 (STKc_PDK1)

164 - 432

CDD
cd05581 (STKc_PDK1)
mobidb-lite (disord...)

1 - 22

MobiDB Lite
mobidb-lite (disorder_prediction)

718 - 741

MobiDB Lite
mobidb-lite (disorder_prediction)

545 - 612

MobiDB Lite
mobidb-lite (disorder_prediction)

667 - 688

MobiDB Lite
mobidb-lite (disorder_prediction)

627 - 651

MobiDB Lite
mobidb-lite (disorder_prediction)

875 - 895

MobiDB Lite
mobidb-lite (disorder_prediction)

494 - 528

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

172L

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

173G

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

174I

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

175G

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

178S

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

180V

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

193A

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

195K

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

214E

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

228I

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

244L

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

245D

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

246Y

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

247A

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

250G

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

251E

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

294E

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

295N

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

297L

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

307T

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)

308D

ATP binding site
172L, 173G, 174I, 175G, 178S, 180V, 193A, 195K, 214E, 228I, 244L, 245D, 246Y, 247A, 250G, 251E, 294E, 295N, 297L, 307T, 308D
CDD
cd05581 (STKc_PDK1)
active site cd05581

172L

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

173G

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

174I

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

175G

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

176S

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

180V

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

193A

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

195K

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

228I

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

244L

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

245D

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

247A

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

251E

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

253L

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

290D

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

292K

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

294E

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

295N

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

297L

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

307T

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

308D

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

311T

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

338F

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

339V

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

340G

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

341T

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

342A

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

343E

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

370Q

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

376P

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

379T

active site
172L, 173G, 174I, 175G, 176S, 180V, 193A, 195K, 228I, 244L, 245D, 247A, 251E, 253L, 290D, 292K, 294E, 295N, 297L, 307T, 308D, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)
polypeptide substr...

176S

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

251E

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

253L

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

290D

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

292K

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

294E

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

311T

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

338F

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

339V

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

340G

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

341T

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

342A

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

343E

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

370Q

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

376P

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)

379T

polypeptide substrate binding site
176S, 251E, 253L, 290D, 292K, 294E, 311T, 338F, 339V, 340G, 341T, 342A, 343E, 370Q, 376P, 379T
CDD
cd05581 (STKc_PDK1)
activation loop (A...

307T

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

308D

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

309F

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

310G

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

311T

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

312A

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

313K

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

314L

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

315L

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

316D

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

317R

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

335A

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

336S

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

337S

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

338F

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

339V

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

340G

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

341T

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

342A

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

343E

activation loop (A-loop)
307T, 308D, 309F, 310G, 311T, 312A, 313K, 314L, 315L, 316D, 317R, 335A, 336S, 337S, 338F, 339V, 340G, 341T, 342A, 343E
CDD
cd05581 (STKc_PDK1)

Protein sequence

>MCA_04953_1
MASKQALSLSPTPSSLSSSSHLSAFNSAKLSPTISPINSEPLCSEKISNPGLITVSTTEIGINSQIALSSPSDDTTSTQP
LNLASDNKNFIISMENQPQLPQNITVNSEPTNSKQPDLVADMASHEPLPRSAEEWREKGAASLIRKESDEKGQVRTYVIK
KGVKDFEFGKTLGIGSYSTVVCGRDKQSLRQYAIKILDKRHIIREKKVKYVEIEKRTLNRLGDHPGIIPLYYTFQDENSL
YFVLDYASNGELLSLITKLGSLDEDCAKYYGAQLLDAIEFMHSRGVIHRDLKPENLLLDDKMRLKVTDFGTAKLLDREID
KDGNELDSYPQNVRASSFVGTAEYVSPELLADKYATKSCDMWAYGCILYQMVAGRPPFTASNEYQIFRKVVKLQYSFPPR
FPTVLRDLIKHLLVLAPERRYTTSQVKRHPFFQGVEWTRNAIWKTPHPRLQPYTYSTKIPTNIPPFGSRAYNPGVNGNGN
ISHNPYISNLARNKTSANSRSSPNLVNTNQTNSAHPPLPKQASGNGLSNKSVVSAAAGAAAALAKPPSSISPYYTPTQPH
SYSSGTNNNQQIKAQPVSKAATRAHVNTSTSNSTTLPQSGNNANATARSKPSNTALVASNLAAVSDGYTDSNKQKQGTQI
SSSEGNSSVDQKKNFKAALTSATIATNSASNTSASQNSTTIKPMEIPPLTKADKDFSSLLTHKDERILKIGQITMSTTSS
TNGSLNDSDTNDKEMPDFNEKEPSRISRLFAGSRKKKRVLFVTTFGRLVVVNGIEDKKVQLDIRVVSPQVVVREFARNKK
TFVGTFAVEAHGRVFTFEDPSGSSDWMKAINKAKEFVENQEQLAAAKTHQTAAAAAMAAAASSAMRLGNVGMGGVNGSTS
RRRSSDIDSMISQPNHSVFLRRSEERKQRNYLN

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component