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Entry type
Status
Per-residue features
Colour by
Protein
MCA_04946_1
Length
1,159 amino acids
Gene name: MIP1
Description: DNA polymerase gamma; mitochondrial
Browser: contigC:4490755-4494306+
RNA-seq: read pairs 1386, FPKM 14.8, percentile rank 33.7% (100% = highest expression)
Protein function
Annotation: | MIP1 | DNA polymerase gamma; mitochondrial | |
---|---|---|---|
KEGG: | K02332 | POLG1 | DNA polymerase gamma 1 [EC:2.7.7.7] |
EGGNOG: | 0PG2A | MIP1 | DNA polymerase gamma |
SGD closest match: | S000005857 | MIP1 | DNA polymerase gamma |
CGD closest match: | CAL0000176297 | orf19.3431 | DNA-directed DNA polymerase gamma (Fragment) |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_04947_1 | 63.51% | 1055 | 0.0 | MIA_04947_1 |
A0A0J9XAM4_GEOCN | 62.37% | 1031 | 0.0 | Similar to Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase OS=Geotrichum candidum GN=BN980_GECA07s00846g PE=4 SV=1 |
A0A060T2W1_BLAAD | 55.50% | 1072 | 0.0 | ARAD1A11572p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A11572g PE=4 SV=1 |
A0A167EFM7_9ASCO | 55.33% | 1014 | 0.0 | DNA-directed DNA polymerase gamma MIP1 OS=Sugiyamaella lignohabitans GN=MIP1 PE=4 SV=1 |
UniRef50_A0A167EFM7 | 55.33% | 1014 | 0.0 | DNA-directed DNA polymerase gamma MIP1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167EFM7_9ASCO |
A0A1E3PH76_9ASCO | 52.76% | 1033 | 0.0 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_60318 PE=4 SV=1 |
Q6C143_YARLI | 47.37% | 1064 | 0.0 | YALI0F19404p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F19404g PE=4 SV=1 |
A0A1E4TAT0_9ASCO | 50.61% | 976 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_32312 PE=4 SV=1 |
DPOG_YEAST | 48.05% | 1028 | 0.0 | DNA polymerase gamma OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MIP1 PE=1 SV=3 |
A0A1D8PPN3_CANAL | 46.49% | 1067 | 0.0 | DNA-directed DNA polymerase gamma (Fragment) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3431 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9867
Predicted cleavage: 36
Protein family membership
Domains and repeats
-
Domain
1
200
400
600
800
1000
1159
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
heterodimer interf...
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DNA binding site c...624NDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)628SDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)631ADNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)632HDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)672TDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)673VDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)674TDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)676RDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)678VDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)679EDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)680KDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)681TDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)777YDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)873TDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)874SDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)877NDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)881QDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)912VDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)913HDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)914DDNA binding site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 777Y, 873T, 874S, 877N, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA) -
active site cd08641624Nactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)628Sactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)631Aactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)632Hactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)672Tactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)673Vactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)674Tactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)676Ractive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)678Vactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)679Eactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)680Kactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)681Tactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)713Dactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)714Vactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)751Tactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)765Ractive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)769Kactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)874Sactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)881Qactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)912Vactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)913Hactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA)914Dactive site
624N, 628S, 631A, 632H, 672T, 673V, 674T, 676R, 678V, 679E, 680K, 681T, 713D, 714V, 751T, 765R, 769K, 874S, 881Q, 912V, 913H, 914D
CDD
cd08641 (DNA_pol_gammaA) -
catalytic site cd0...713D714V716S751T765R769K914D
Protein sequence
>MCA_04946_1 MNIISLRSPCTTIGIRFRRPSAIFLRRLTNLSEKGIETGKENDLRINPVGIQYLPSNLQNQLFKSKSTIIPNRSTSKLSS SSLKKLQEIEDKNLVQLAIKHLKNNDLYGKKTSILPPVDLKLPKLVGDSLDEHFYKLGVYASEPYLSKAKQFASQSIPDI PTPDRWVQQSGWTKYHANGNTPIKVDYPDEKDALVLDVEVLYKISDFPIFAVAVSNSAWYCWVSPWFLGESESPRHLIPL GSEEEKLVIGHNVSYDRQRIKEEYSIHLSNSMFLDTMSLHIAVSGMCSRQRPDMIRVKRAKKSSEDVERDATAFSLLDEE IGENPWIQVSSLNNLADVAYLHCGIQHDKGVRDSFGKMTRQEARDQFNKLVDYCARDVATTFEVYKHLLPKFLTVIPHPV SFAGIRHMGSLFLPINHSWEKYLADSERCYEEHQGKLYDSLVKLANTAVELRDTPEKWRSDPWLRQLDWTITPIKMVKPK KKGELPRPAKRQKLPGYPKWYKDLFPTANSPMNISVRCRTAVFLLRLQWDGNPLIWSQSHGFVFKVPKANKQMFLDKNYS LADMNNDPDLSFKDDVNSVYFKIPHKDGPKAKCTSPMTASYYDYFDKKILSSEYDLAAEALKVNMSCSYWAHNRERAKSQ LAIWSDDTNMGIKVQSPKDFGMILPSLITMGTVTRRAVEKTWLTASNAKKNRIGSEQKSMIQAPPGYKFVGADVDSEELW IASLLGDSMFKIHGGTALGWMTLEGTKSEGTDLHSKTASILGISRNEAKVFNYGRIYGAGVTFAAQLLKQFNPRLTEKEA KETAKKLYSLTKGVKSHSESLKLSKFWRSGSESLIFNRLEEMADQETPRTPVLGATITEALQRKNLKKSSFLTSRINWTI QSSGVDYLHLLITSMHYLIKKYGISARLFVTVHDEIRYMVKEEDAYRVALALQISNIWTRAMFCHQVGINDLPLSCAFFS SVDIDHVLRKEVDLDCVTLSHPNPIKPGSSIDIFNTLKVCSTLDKPNSSKFTQDNDLGFQFDFDKVEYQPITPVILELDS KKGSLVPSIAAQISTSTKELRAVEYITDHCESDWSSFFTDEKKTLFINGKSKTVRKSTKDNLKTVSKQKRVTKTGSITPV FGTLEKKKKKLQLTYHNKIKKKMYQIPLMFLMTMRYPIY
GO term prediction
Biological Process
GO:0006260 DNA replication
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Cellular Component
GO:0005760 gamma DNA polymerase complex