Protein

MCA_04938_1

Length
985 amino acids

Gene name: STE11

Description: Serine/threonine-protein kinase Ste11; signal transducing MEK kinase; in S. cerevisiae involved in pheromone response and pseudohyphal/invasive growth pathways

Browser: contigC:4473725-4476767-

RNA-seq: read pairs 1869, FPKM 23.4, percentile rank 45.8% (100% = highest expression)

Protein function

Annotation:STE11Serine/threonine-protein kinase Ste11; signal transducing MEK kinase; in S. cerevisiae involved in pheromone response and pseudohyphal/invasive growth pathways
KEGG:K11228STE11 mitogen-activated protein kinase kinase kinase [EC:2.7.11.25]
EGGNOG:0PG4HSTE11kinase kinase kinase
SGD closest match:S000004354STE11Serine/threonine-protein kinase STE11
CGD closest match:CAL0000193264STE11Mitogen-activated protein kinase kinase kinase

Protein alignments

%idAln lengthE-value
A0A0J9X317_GEOCN77.90%2765e-140Similar to Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways, and the high osmolarity response pathway OS=Geotrichum candidum GN=BN980_GECA02s01352g PE=4 SV=1
UniRef50_A0A0J9X31777.90%2769e-137Similar to Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways, and the high osmolarity response pathway n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X317_GEOCN
MIA_04395_170.59%2721e-129MIA_04395_1
B5BLP7_BLAAD71.17%2742e-128Serine/threonine-protein kinase Aste11p OS=Blastobotrys adeninivorans GN=aste11 PE=4 SV=1
A0A167BWF7_9ASCO71.48%2704e-126Mitogen-activated protein kinase kinase kinase STE11 OS=Sugiyamaella lignohabitans GN=STE11 PE=4 SV=1
A0A1E3PRS4_9ASCO69.49%2721e-121Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81184 PE=4 SV=1
F2Z643_YARLI66.91%2691e-115YALI0F13629p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13629g PE=4 SV=1
A0A1E4TLQ6_9ASCO62.82%2772e-111Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30775 PE=4 SV=1
A0A1D8PGY4_CANAL60.50%2814e-103Mitogen-activated protein kinase kinase kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=STE11 PE=4 SV=1
STE11_YEAST54.05%3096e-101Serine/threonine-protein kinase STE11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE11 PE=1 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0094

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 985

Detailed signature matches

  1. Domain IPR013761
    Sterile alpha motif/pointed domain
    1. SSF47769 (SAM/Point...)
  2. Domain IPR001660
    Sterile alpha motif domain
    1. PF00536 (SAM_1)
    2. PS50105 (SAM_DOMAIN)
    3. SM00454 (SAM_4)
  3. Domain IPR029458
    Ras-binding domain of Byr2
    1. SM01304 (Ras_bdg_2_2)
    2. PF14847 (Ras_bdg_2)
  4. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  5. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  6. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  7. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.15...
  3. G3DSA:1.10.51...
  4. G3DSA:3.10.20.90
  5. G3DSA:3.30.20...
  6. cd09534 (SAM_Ste11_...)
  7. mobidb-lite (disord...)

Residue annotation

  1. putative heterodim...
  2. heterodimer interf...
  3. homodimer interfac...

Protein sequence

>MCA_04938_1
MDAYLPPPEPLSPLRSSFAFSGDLPSPTSETLEPSSTPSTSNTTFTLSTSAGNVSPGYSVLSSATSDYTSPASASSFPLS
PVSSWTNQQLRDWLECLHCGAYYRTFEDNHITGDILLECDDSSLRDMGIRKVGDRIRIQQSLNKLRKQAAKTHFIEIQHN
NLEVPGNNNNNKGSASSKHRYSNSPNSKGNSPIDGFFTPTGPPPVSSSNLQNPNRLPEILPGLPSKPRSGNSTAQTQTNS
SRNHYHSAPSSATIDPRSQSSNHQTDQVKKILSMDDVKQSTVRFINTKGQCKTSNISGYFSGPSIKRKALKKFSIKENPD
NWVVFIADNELGTTTRRVNDLEIVTICHSQDRLERYRLMLCPVGTTPTIEQLSKSQQILRDSITKAAVAAAAALPDLSNP
SYQPQPHSANSVQSFDEKELSSSHNNNSKHNIQYNSHDYTNYNMNTSNSEKYTNLTPTSDITSQNTKGTAPLILSSAKRM
RKFYGQRPPSELISSNLQEYFPEAGPKVLEETIRNSIMFKRMSRMSRLSQRSSIASGWGIPDSEADAPPIPSLDEIWDEA
QGDKPTLSLKPSGLPTSSSSSLATGSTSSLPSSPINMTPSLPNPSTRNKKPLYLQQNSSFGSISNNKSGSAGSKGSESAS
TSNLPSFDEKTLPPVPQQFSSDRRSSSFSTPHTDNTDNNNNNGTLTPKQLQDGSQSNTGDNIEEEYMELLQQEQSGPSKW
IKGTLIGSGSFGTVYLGMNSITGELMAVKQVELLSDKSDEHEQRKKSMIDALQREMKLLQDLQHPNIVQYLGSNCENNYL
NIYLEYVPGGSVATMLSNYGAFEESLIRNFVKQILHGLKYLHDRSIIHRDIKGANVLVDNKGTIKISDFGISKKLEDKNA
RTSLQGSVYWMAPEVVKQKPYTFKADIWSLGCLIVEMFTGSRPFPEFQHLQALFNIGKETPVPPTIPEQATPEAQNFLKQ
AFEIDYNKRPTAQEMLQHQFLKTLI

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

None predicted.