Protein

MCA_04907_1

Length
448 amino acids

Gene name: TUB2A

Description: Tubulin beta chain

Browser: contigC:4387542-4389191+

RNA-seq: read pairs 14278, FPKM 392.9, percentile rank 93.4% (100% = highest expression)

Protein function

Annotation:TUB2ATubulin beta chain
KEGG:K07375TUBB tubulin beta
EGGNOG:0PIDETUB2Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain
SGD closest match:S000001857TUB2Tubulin beta chain
CGD closest match:CAL0000176403TUB2Tubulin beta chain

Protein alignments

%idAln lengthE-value
MIA_06139_192.56%4300.0MIA_06139_1
TBB1_GEOCN86.05%4300.0Tubulin beta-1 chain OS=Geotrichum candidum PE=3 SV=2
A0A1E3PFH7_9ASCO84.65%4300.0Tubulin beta chain OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47457 PE=3 SV=1
A0A1D8PC97_CANAL82.33%4300.0Tubulin beta chain OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TUB2 PE=3 SV=1
Q6C7H8_YARLI81.63%4300.0Tubulin beta chain OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E00726g PE=3 SV=1
A0A060T354_BLAAD81.63%4300.0Tubulin beta chain OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A06952g PE=3 SV=1
UniRef50_P6837180.56%4270.0Tubulin beta-4B chain n=276 Tax=Eukaryota TaxID=2759 RepID=TBB4B_HUMAN
TBB_YEAST80.23%4300.0Tubulin beta chain OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUB2 PE=1 SV=2
A0A1E4TEH0_9ASCO75.58%4300.0Tubulin beta chain (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_60471 PE=3 SV=1
A0A161HF60_9ASCO87.07%3480.0Tubulin beta chain OS=Sugiyamaella lignohabitans GN=TUB2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0425

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 448

Detailed signature matches

  1. Family IPR000217
    Tubulin
    1. PR01161 (TUBULIN)
  2. Family IPR002453
    Beta tubulin
    1. PR01163 (BETATUBULIN)
  3. Domain IPR003008
    Tubulin/FtsZ, GTPase domain
    1. PF00091 (Tubulin)
    2. SM00864 (Tubulin_4)
    3. G3DSA:3.40.50...
    4. SSF52490 (Tubulin n...)
  4. Domain IPR008280
    Tubulin/FtsZ, C-terminal
    1. SSF55307 (Tubulin C...)
  5. Domain IPR018316
    Tubulin/FtsZ, 2-layer sandwich domain
    1. PF03953 (Tubulin_C)
    2. SM00865 (Tubulin_C_4)
    3. G3DSA:3.30.13...
  6. SITE IPR013838
    Beta tubulin, autoregulation binding site
    1. PS00228 (TUBULIN_B_...)
  7. SITE IPR017975
    Tubulin, conserved site
    1. PS00227 (TUBULIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.28...
  3. cd02187 (beta_tubulin)

Residue annotation

  1. beta/alpha domain ...
  2. nucleotide binding...
  3. Taxol binding site...
  4. alpha/beta domain ...

Protein sequence

>MCA_04907_1
MREIIHLSAGQCGNQIGSSFWQTISDEHGIDPSGNYVGDNPLQLERLNVYYNEATHGKYVPRAVLVDLEPGTMDAVRGGP
FGNLFRPDNFVFGQSSAGNNWAKGHYTEGAELVDNVLDVVRREAEGCDSLQGFQVSHSLGGGTGSGMGTLLISRMREEYP
DRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENADETFCIDNEALYDICQKTLKLPQPTLTDLNQLVSAVMSGITTCL
RFPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLSASGSKSFRSLTVPELTQQMFDPKNMMAASDPRHGRYLTVASFFRGQ
VSVKEVEDQMRIVQEKNAGYFVEWIPNNVQTAICSIPPKDVSMSATFVANSTSIQELFKRVGDQFSAMFRRKAFLHWFTS
EGMEESEFTEAESNMADLVSEYQQYQDATIDDEEYEYEDEQLIDQSLQ

GO term prediction

Biological Process

GO:0007017 microtubule-based process

Molecular Function

GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Cellular Component

GO:0005874 microtubule