Protein

MCA_04773_1

Length
285 amino acids

Gene name: PRE2

Description: Proteasome subunit beta type-5

Browser: contigC:3994489-3995415+

RNA-seq: read pairs 4158, FPKM 179.6, percentile rank 86.8% (100% = highest expression)

Protein function

Annotation:PRE2Proteasome subunit beta type-5
KEGG:K02737PSMB5 20S proteasome subunit beta 5 [EC:3.4.25.1]
EGGNOG:0PFGVFG06886.1The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)
SGD closest match:S000006307PRE2Proteasome subunit beta type-5
CGD closest match:CAL0000200516PRE2Proteasome core particle subunit beta 5

Protein alignments

%idAln lengthE-value
MIA_05232_188.07%2850.0MIA_05232_1
A0A0J9XEC7_GEOCN83.57%2861e-177Similar to Saccharomyces cerevisiae YPR103W PRE2 Beta 5 subunit of the 20S proteasome OS=Geotrichum candidum GN=BN980_GECA12s00626g PE=4 SV=1
A0A060TD53_BLAAD79.15%2832e-170ARAD1D48246p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D48246g PE=4 SV=1
Q6CEJ2_YARLI76.31%2874e-164YALI0B15224p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B15224g PE=4 SV=1
PSB5_YEAST76.31%2873e-163Proteasome subunit beta type-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRE2 PE=1 SV=3
UniRef50_P3065676.31%2876e-160Proteasome subunit beta type-5 n=612 Tax=Eukaryota TaxID=2759 RepID=PSB5_YEAST
A0A1E3PDZ6_9ASCO74.91%2833e-161N-terminal nucleophile aminohydrolase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84580 PE=4 SV=1
Q59Z65_CANAL83.61%2444e-157Proteasome core particle subunit beta 5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PRE2 PE=4 SV=1
A0A1E4TIK0_9ASCO79.12%2491e-152Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_124 PE=4 SV=1
A0A167CVR0_9ASCO84.30%1721e-107Proteasome core particle subunit beta 5 OS=Sugiyamaella lignohabitans GN=PRE2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0832

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 285

Detailed signature matches

  1. Family IPR001353
    Proteasome, subunit alpha/beta
    1. PF00227 (Proteasome)
  2. Family IPR023333
    Proteasome B-type subunit
    1. PS51476 (PROTEASOME...)
  3. Family IPR000243
    Peptidase T1A, proteasome beta-subunit
    1. PR00141 (PROTEASOME)
  4. Domain IPR029055
    Nucleophile aminohydrolases, N-terminal
    1. G3DSA:3.60.20.10
    2. SSF56235 (N-termina...)
  5. SITE IPR016050
    Proteasome beta-type subunit, conserved site
    1. PS00854 (PROTEASOME...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd03761 (proteasome...)

Residue annotation

  1. active site cd03761
  2. beta subunit inter...

Protein sequence

>MCA_04773_1
MDAIVNKYATPLGAQSSLIDQEEQEFLNSEVVSGVPSISLPPISRPTAFLRAHTDDNANPDVKIKIAHGTTTLAFRFQGG
IVVAVDSRATAGNWVSSQTVKKVIEINPFLLGTMAGGAADCQFWETWLGMQCRLHELREKSRISVAAASKILANLTYEYK
GMGLSMGTMICGYTKLEGPAIYYVDSDGTRLKGDLFCVGSGQTFAYGVLDASYKWDLSVEEALALGKRSILAATHRDAYS
GGSVNLYHVTENGWIYHGNYDVKTEFWNAKEAEGSFNNIVTKLPN

GO term prediction

Biological Process

GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex