Protein
MCA_04726_1
Length
796 amino acids
Gene name: HST1
Description: NAD-dependent protein deacetylase HST1; Sirtuin family protein
Browser: contigC:3823468-3825859+
RNA-seq: read pairs 2186, FPKM 33.9, percentile rank 56.1% (100% = highest expression)
Protein function
| Annotation: | HST1 | NAD-dependent protein deacetylase HST1; Sirtuin family protein | |
|---|---|---|---|
| KEGG: | K11121 | SIR2 | NAD-dependent histone deacetylase SIR2 [EC:3.5.1.-] |
| EGGNOG: | 0PGKD | SIR2 | histone deacetylase |
| SGD closest match: | S000005429 | HST1 | NAD-dependent protein deacetylase HST1 |
| CGD closest match: | CAL0000190389 | HST1 | NAD-dependent protein deacetylase HST1 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_03760_1 | 57.93% | 511 | 0.0 | MIA_03760_1 |
| A0A0J9X9A4_GEOCN | 63.57% | 269 | 6e-116 | Similar to Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan OS=Geotrichum candidum GN=BN980_GECA05s06775g PE=4 SV=1 |
| UniRef50_A0A0J9X9A4 | 63.57% | 269 | 1e-112 | Similar to Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X9A4_GEOCN |
| A0A167D863_9ASCO | 52.74% | 292 | 4e-92 | Histone deacetylase HST1 OS=Sugiyamaella lignohabitans GN=HST1 PE=4 SV=1 |
| A0A060SZ10_BLAAD | 47.89% | 284 | 7e-76 | ARAD1A16082p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A16082g PE=4 SV=1 |
| HST1_CANAL | 50.21% | 239 | 4e-67 | NAD-dependent protein deacetylase HST1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST1 PE=3 SV=2 |
| HST1_YEAST | 55.85% | 188 | 2e-63 | NAD-dependent protein deacetylase HST1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST1 PE=1 SV=1 |
| A0A1E3PEE8_9ASCO | 57.74% | 168 | 2e-62 | SIR2-domain-containing protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_5130 PE=4 SV=1 |
| A0A1E4TGZ2_9ASCO | 47.81% | 228 | 1e-57 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_148141 PE=4 SV=1 |
| Q6C219_YARLI | 52.35% | 170 | 2e-53 | YALI0F11583p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F11583g PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0184
Protein family membership
- Sirtuin family (IPR003000)
Domains and repeats
-
Domain
-
Domain
1
100
200
300
400
500
600
700
796
Detailed signature matches
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_04726_1 MSAEIPSKEPDTKKNLDFFFPKVSGTSTPPAKRIKLEDGTSSAVIPLSIEEPELVLVKEEPQPAQKTTSSEQLSAITTKQ QTSTLLDSFLKSSFSSPVLFNETPSDSDAVTSVTDPSDNDDPTVTQSKPNNDITENKPSSEESEAQITKSNNTYQVVEVV PEKKKDALDSVSPMFAKLFEDKIRDMTEAGSFPSEFVSLAGLFRQIYKQQRNATRQLNGEEISDSSSEEDDDESDDDQEE EDEFNIFSRDIEMELTHDQLLKKMEESLSNGNPISPDTPRVTISHKVASQLKMDLWMKGPYMFVQQYLYSAHSMVTPAEV LAALSFPLPEHLVTRSNADDLIQFAVQATKFTVMPRKRSSTPLTIDSLVKEIENAKNVIVLTGAGISTSLGIPDFRSKSG LYNKLSYLGLSDPQEVFYLSTFKKDPSIFYSIAKEILPVTSKFSPTHSFIKLLQDKGKLLRNYTQNIDNLEYYAGVLPEK LIQCHGSFAFATCQTCGYKTKGETIFEDIRNQVVARCPVCKKQAAKSLLQESENNNNSNKNNSKSNSKKKNKSSNTWDDS GSESDDNPKFTDTSSHFHMGGKVYGILDPKNKSEMKYRPTKSSRSTYEHYGGPMSISANMRKSPLFGVMKPDITFFGEPL PHTFEETLIGNDSDKCDLLLCIGTSLKVSPVSETVRIIPSNVTQVYISKTAITHNEFELTLLGACDDVIEHLVRKLGWEF QHPMLKNIDMDPYIEYKADMATYEFNTDHLVNQPQGSSASSSSSSSSTSSNTTATSNNSSDNSSSNNNNNDTTTTK
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0070403 NAD+ binding
Cellular Component
None predicted.