Protein

MCA_04711_1

Length
900 amino acids

Gene name: FRE3B

Description: Ferric reductase transmembrane component 3

Browser: contigC:3781922-3784625-

RNA-seq: read pairs 2197, FPKM 30.1, percentile rank 52.9% (100% = highest expression)

Protein function

Annotation:FRE3BFerric reductase transmembrane component 3
EGGNOG:0PHSNFG01789.1Ferric-chelate reductase
SGD closest match:S000005908FRE3Ferric reductase transmembrane component 3
CGD closest match:CAL0000185898CFL4Ferric/cupric-chelate reductase

Protein alignments

%idAln lengthE-value
MIA_02081_158.50%8940.0MIA_02081_1
A0A060T7K7_BLAAD41.94%6511e-175ARAD1C28952p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C28952g PE=4 SV=1
UniRef50_A0A060T7K741.94%6513e-172ARAD1C28952p n=1 Tax=Blastobotrys adeninivorans TaxID=409370 RepID=A0A060T7K7_BLAAD
Q6C208_YARLI35.33%5692e-105YALI0F11825p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F11825g PE=4 SV=1
A0A1E3PKS3_9ASCO32.24%6085e-101Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51285 PE=4 SV=1
A0A1D8PN54_CANAL33.33%5851e-68Ferric/cupric-chelate reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CFL4 PE=4 SV=1
A0A0J9XIC4_GEOCN28.16%5931e-66Similar to Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters OS=Geotrichum candidum GN=BN980_GECA19s01132g PE=4 SV=1
A0A167FY66_9ASCO28.21%6383e-60Fre2p OS=Sugiyamaella lignohabitans GN=FRE2 PE=4 SV=1
FRE3_YEAST29.62%5308e-55Ferric reductase transmembrane component 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FRE3 PE=1 SV=1
A0A1E4TJY1_9ASCO25.96%6244e-52Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_81144 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6670

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 900 900

Detailed signature matches

  1. Domain IPR013130
    Ferric reductase transmembrane component-like domain
    1. PF01794 (Ferric_reduct)
  2. Domain IPR017938
    Riboflavin synthase-like beta-barrel
    1. SSF63380 (Riboflavi...)
  3. Domain IPR017927
    Ferredoxin reductase-type FAD-binding domain
    1. PS51384 (FAD_FR)
  4. Domain IPR013112
    FAD-binding 8
    1. PF08022 (FAD_binding_8)
  5. Domain IPR013121
    Ferric reductase, NAD binding domain
    1. PF08030 (NAD_binding_6)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. Coil
  3. G3DSA:2.40.30.10
  4. G3DSA:3.40.50.80
  5. NON_CYTOPLASM... (N...)
  6. SFLDG01168 (Ferric_...)
  7. SFLDS00052 (Ferric_...)
  8. SIGNAL_PEPTIDE (Sig...)
  9. SIGNAL_PEPTID... (S...)
  10. SIGNAL_PEPTID... (S...)
  11. SIGNAL_PEPTID... (S...)
  12. SSF52343 (Ferredoxi...)
  13. SignalP-noTM
  14. TMhelix
  15. TRANSMEMBRANE (Tran...)
  16. cd06186 (NOX_Duox_l...)

Residue annotation

  1. FAD binding pocket...
  2. FAD binding motif ...
  3. beta-alpha-beta st...
  4. NAD pyrophosphate ...
  5. NAD binding pocket...
  6. NADP ribose bindin...

Protein sequence

>MCA_04711_1
MVFLSINSAFAISAMLILSTILGSVSAMWPHSKIIGNVCQVVSGNNFDACSKSEEECLCTNPNYLATVALCINQNLNTTK
SVDEAWNFVLLDKCKQTLEVAEKAYKSAMRLLNQTNVTVLNEESNPNENYTNPVIPSKESVKDTYTSIYINLYNRDIGTW
QGSALVLYWVVVIGIAGIYRLWRYIMVSFAPKRQSMGRPNRLMRMYYKHIKLPATFGLRHIDRYYLFGFIPVFIPTRYET
ILISIYMILTIIFMCCGYVFMNNNPLWNTHYSELVLNVSNRAGIIAAIQIPLLTLFALRNNILIWITGWSYSSFNAYHRG
IARITFLLGVTHAAAKHSMMLTFGMPLRMIYYPTVLFRLGTAALVIWIFMILLGFFRVRFYEIFLFFHVLGAISAYICLI
YHLHGLGYKQTVYIALGFILADIIIRVTRIVFSNASIILKPIEGSKSLTKANVSLLASDVINVRIRTPIQWPFAPGQYVY
IHFNRINIFESHPFSAVGPSSDGESFQLLCKARGGITKRVKEYLEKEGASATNGRKIKMNVLIEGPYGVHCPVERYDTVL
LVAGGIGITGIIPYAEYLALSPNYHDIILIWTVSTVDELTWIEERLQWLSETAKAKIKLYVTRVSKKIEQPVDSTNVIVM
KELGVGHNTTPMELAHKRSGETDSFRLVGEGINFQKSYDNGVKRKLSIRKHIRNISQNSNVFAVDIDQRMENVDGGDMVD
WTHNEGQAYPHQHLRTNSRGQQIYTQLAPPIEEESEGSKMGCAYKMPRQAPNNYRNSYRYSYNPTKRNSAIFNNSSDIPS
YDGYAAHNIVPPPHAGVKGDHKISINEISRQQLWMDNIIEGTRPNLMETVSELFREAPGSVCIVGCGPARMMDTLRKATC
LNYDLVQHGRLDYFEEAFTW

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.