Protein
MCA_04705_1
Length
689 amino acids
Gene name: LYS4
Description: Homoaconitase, mitochondrial
Browser: contigC:3771480-3773550-
RNA-seq: read pairs 1349, FPKM 24.2, percentile rank 46.7% (100% = highest expression)
Protein function
Annotation: | LYS4 | Homoaconitase, mitochondrial | |
---|---|---|---|
KEGG: | K01705 | LYS4 | homoaconitate hydratase [EC:4.2.1.36] |
EGGNOG: | 0PH1K | LYS4 | Responsible for the dehydration of cis-homoaconitate to homoisocitric acid (By similarity) |
SGD closest match: | S000002642 | LYS4 | Homoaconitase, mitochondrial |
CGD closest match: | CAL0000195924 | LYS4 | Homoaconitase, mitochondrial |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_05896_1 | 85.96% | 684 | 0.0 | MIA_05896_1 |
A0A0J9XHA5_GEOCN | 79.94% | 688 | 0.0 | Homoaconitase, mitochondrial OS=Geotrichum candidum GN=BN980_GECA16s02177g PE=3 SV=1 |
LYS4_YARLI | 76.97% | 686 | 0.0 | Homoaconitase, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LYS4 PE=3 SV=1 |
A0A167CU71_9ASCO | 76.75% | 671 | 0.0 | Homoaconitase, mitochondrial OS=Sugiyamaella lignohabitans GN=LYS4 PE=3 SV=1 |
A0A060TC05_BLAAD | 75.11% | 675 | 0.0 | Homoaconitase, mitochondrial OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B12980g PE=3 SV=1 |
A0A1E3PKR7_9ASCO | 73.23% | 691 | 0.0 | Homoaconitase, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51169 PE=3 SV=1 |
LYS4_CANAL | 71.87% | 686 | 0.0 | Homoaconitase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LYS4 PE=3 SV=1 |
A0A1E4TDG5_9ASCO | 72.07% | 673 | 0.0 | Homoaconitase, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_144314 PE=3 SV=1 |
LYS4_YEAST | 68.42% | 703 | 0.0 | Homoaconitase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS4 PE=1 SV=1 |
UniRef50_P49367 | 68.42% | 703 | 0.0 | Homoaconitase, mitochondrial n=264 Tax=root TaxID=1 RepID=LYS4_YEAST |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9640
Predicted cleavage: 31
Protein family membership
- Homoaconitase, mitochondrial (IPR004418)
Domains and repeats
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Domain
-
Domain
1
100
200
300
400
500
600
689
Detailed signature matches
Residue annotation
-
substrate binding ...
-
ligand binding sit...
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substrate binding ...
Protein sequence
>MCA_04705_1 MITLSSFSRFGSIYRSSIIRRGLATASRIPQNLTEKIVQKYAVGLSPGKVVQSGDYVSVRPSHCMTHDNSWPVALKFMGL GATRVKDNRQVVLTLDHDVQNKSEKNLEKYKNIENFGRKQGIDFYPAGRGIGHQIMVEEGYAFPYNLTVASDSHSNTYGG VGCLGTPIVRTDAASVWATGQTWWQVPPVAKVELQGKLPAGSTGKDVIVALCGVFNNDEVLNHAIEFVGDGLNHLSVDER LTIANMTTEWGALSGLFPVDDVLINWYKTRLQILPQPHPRVNAETVSNIEKNRVAADPDARYAKKLTIDLSTLSPIVSGP NSVKISTPLSELSAKNIPIHKAYLVSCTNSRLSDIEAAAKVIKGKKVADGVEFYVGAASSFVQKDAEKSGAWKDLLDAGA VPLPAGCGPCIGLGTGLLKDGEVGISATNRNFKGRMGSRDALAYLASPEVVAASAVLGKIGFPEEIDGKLPANIGAIKSS IEYPQESAESSAPAEESAAGSVLEGFPEVIEGELVLCDQDNINTDSIYPGKYTYEDDISREKMAQVCMENYDPDFGKKTK AGDVIVSGFNFGTGSSREQAATCILARGIQLVVAGSFGNIFSRNSINNALLTLEIPALINMLREKYKDDKDVTQRTGWFI KWDVKTATVTVTDGQNGPVILKQKVGELGQNLQEIIVKGGLEGWVKAQL
GO term prediction
Biological Process
GO:0008152 metabolic process
GO:0009085 lysine biosynthetic process
Molecular Function
GO:0004409 homoaconitate hydratase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Cellular Component
None predicted.