Protein

MCA_04659_1

Length
1,073 amino acids

Gene name: CDC24

Description: Cell division control protein 24

Browser: contigC:3626466-3629827-

RNA-seq: read pairs 5658, FPKM 65.1, percentile rank 71.0% (100% = highest expression)

Protein function

Annotation:CDC24Cell division control protein 24
KEGG:K11236CDC24 cell division control protein 24
EGGNOG:0QE93FG10511.1nucleotide exchange factor
SGD closest match:S000000039CDC24Cell division control protein 24
CGD closest match:CAL0000190069CDC24Rho family guanine nucleotide exchange factor

Protein alignments

%idAln lengthE-value
MIA_00115_159.59%5890.0MIA_00115_1
A0A0J9XJZ2_GEOCN64.62%4550.0Similar to Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p OS=Geotrichum candidum GN=BN980_GECA24s00758g PE=4 SV=1
UniRef50_A0A0J9XJZ264.62%4550.0Similar to Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XJZ2_GEOCN
A0A167FRH5_9ASCO48.98%5883e-162Rho family guanine nucleotide exchange factor CDC24 OS=Sugiyamaella lignohabitans GN=CDC24 PE=4 SV=1
A0A060T2M6_BLAAD54.08%4538e-142ARAD1A02662p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A02662g PE=4 SV=1
Q6CBW7_YARLI48.69%4586e-122YALI0C14828p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C14828g PE=4 SV=1
A0A1D8PNB5_CANAL33.44%6017e-82Rho family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CDC24 PE=4 SV=1
A0A1E3PDB6_9ASCO43.69%3255e-74Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84393 PE=4 SV=1
A0A1E4THH4_9ASCO36.04%4443e-72Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_14730 PE=4 SV=1
CDC24_YEAST33.20%5037e-68Cell division control protein 24 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC24 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0927

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1000 1073

Detailed signature matches

  1. Domain IPR010481
    Cdc24/Scd1, N-terminal
    1. PF06395 (CDC24)
  2. Domain IPR000219
    Dbl homology (DH) domain
    1. SSF48065 (DBL homol...)
    2. PF00621 (RhoGEF)
    3. PS50010 (DH_2)
    4. SM00325 (RhoGEF_3)
  3. Domain IPR011993
    PH domain-like
    1. G3DSA:2.30.29.30
    2. SSF50729 (PH domain...)
  4. Domain IPR033511
    Rho guanine nucleotide exchange factor Cdc24/Scd1, PH domain
    1. cd13246 (PH_Scd1)
  5. Domain IPR000270
    PB1 domain
    1. PS51745 (PB1)
    2. PF00564 (PB1)
    3. SM00666 (PB1_new)
  6. SITE IPR001331
    Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    1. PS00741 (DH_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.56...
  3. G3DSA:1.20.90...
  4. G3DSA:3.10.20.90
  5. PF15411 (PH_10)
  6. SSF54277 (CAD & PB1...)
  7. cd00160 (RhoGEF)
  8. cd05992 (PB1)
  9. mobidb-lite (disord...)

Residue annotation

  1. GTPase interaction...
  2. PB1 interaction cd...
  3. PB1 interaction su...
  4. PB1 interaction su...
  5. PB1 interaction si...
  6. PB1 interaction su...

Protein sequence

>MCA_04659_1
MSSSVLSNSQIPPTPSSTSIPTPPSLPQPQQLQLQQQPQPLQQSQPQQQTLQQQQQQQQQQQQQQHNPSISSASNVSIST
LNTNSTVLPSSLNKNYDNYVSLFQAAAQMKERLLEVPHLAPFLELCIGNTTNLAALQKLYAELNAKAQQKLNSLANTNDK
TNMTSAFPIISSSSSSNSASESNRNSSNDLLVQNITGSSFSLSPTSPIIPLGKKIDPVTHLWQFFRLGSSLCALFNELNP
KVPLKVLITTDVKSCKRSVYDFVQGCKSELGYTDEELFTITNVFSDSTTDLLKVLRTVDLVLDTLAQREVISPKKPIPKT
IPADPKDKRAKAVEELLITERHYVYDLERLYDYQCALQTLNLLTADTIHFLFPNLNVLVDFQRRFLIGIEYHSQLPIEEQ
RIGSVFLNFQDGFEVYEGFALNQKKAVEIARAETDKLKTLSYKMDPVYELPSLLIKPIQRICKYPLLLQQLIKFTPKDAP
NYQDQLDAFASIRHVTQQVNETQRRVENLGIVQQLAERLADWKGHNLDDFGALLHEGVFPVLKAGTEREYHLFLFEHIIL
CCKEAPPSKKSMTLSTKKSKPKKTVTGTGPLILKGRIYIAYITDVTPIKSNGYFLHIAWGRDDASDTGFFDIRFRNDEQL
DQWETTISQMVARYNNEPNSDIEDSIQYQQYQIQQIQLQRLHNQQQGFTNNPQFFHQNQGRQNSQSFDRSTLVNGTSYDD
ASDDEGINQRQKSYTDDEATPRTTLTYPIDQAKEQQQSSLMSSGGMNNALYQQQIEALTQDISNSRLTNGPHGKHTSHQE
PSTGQMGPSNMPIMNRSASFPAVTGLGPGMRPMNSNNNSNNMAPLYDIYNQQTASTATSATNSMTDVSETSLSSTSPSHL
VKSSNMNGYDDNSWSSVNQRGQMLPSNNGNGRSGSNSSINNQFSQAYTNGSSGGQSNGTTPTSANGGGLNSNKNSFSSMS
NLKGGAQIKVKLHYLDDTFLLIVPSSVSYEQLVDRAERKIRLCGKETPNPLRLKYKDEDDDFVTMRSDEDIIMALEQQGF
LDGSCDFGEDEDAFTNGIMKSFKNNELLIIWAA

GO term prediction

Biological Process

GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction

Molecular Function

GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Cellular Component

None predicted.