Protein

MCA_04647_1

Length
352 amino acids

Gene name: HOG1

Description: Mitogen-activated protein kinase Hog1; S. cerevisiae homologue is involved in osmoregulation.

Browser: contigC:3595243-3596604-

RNA-seq: read pairs 2896, FPKM 101.4, percentile rank 78.9% (100% = highest expression)

Protein function

Annotation:HOG1Mitogen-activated protein kinase Hog1; S. cerevisiae homologue is involved in osmoregulation.
KEGG:K04441P38 p38 MAP kinase [EC:2.7.11.24]
EGGNOG:0PF8JHOG1Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes
SGD closest match:S000004103HOG1Mitogen-activated protein kinase HOG1
CGD closest match:CAL0000197240HOG1Mitogen-activated protein kinase HOG1

Protein alignments

%idAln lengthE-value
MIA_01159_193.93%3460.0MIA_01159_1
A0A0J9X7K5_GEOCN88.86%3500.0Mitogen-activated protein kinase OS=Geotrichum candidum GN=BN980_GECA03s07666g PE=3 SV=1
A0A060T9W0_BLAAD88.15%3460.0Mitogen-activated protein kinase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D22154g PE=3 SV=1
A0A1E3PK72_9ASCO87.86%3460.0Mitogen-activated protein kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_46436 PE=3 SV=1
HOG1_YARLI86.42%3460.0Mitogen-activated protein kinase HOG1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HOG1 PE=3 SV=1
UniRef50_Q9UV5082.03%3450.0Mitogen-activated protein kinase HOG1 n=68 Tax=Fungi TaxID=4751 RepID=HOG1_DEBHA
HOG1_YEAST82.80%3430.0Mitogen-activated protein kinase HOG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOG1 PE=1 SV=2
HOG1_CANAL79.71%3450.0Mitogen-activated protein kinase HOG1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HOG1 PE=1 SV=2
A0A1E4TJB7_9ASCO78.06%3510.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_432 PE=3 SV=1
A0A161HI89_9ASCO89.15%2950.0Mitogen-activated protein kinase OS=Sugiyamaella lignohabitans GN=HOG1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.4100

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 352

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. PF00069 (Pkinase)
    3. SM00220 (serkin_6)
  3. SITE IPR017441
    Protein kinase, ATP binding site
    1. PS00107 (PROTEIN_KI...)
  4. SITE IPR003527
    Mitogen-activated protein (MAP) kinase, conserved site
    1. PS01351 (MAPK)
  5. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. PF12330 (Haspin_kinase)
  4. PIRSF000654 (ILK)
  5. cd07856 (STKc_Sty1_...)

Residue annotation

  1. ATP binding site c...
  2. active site cd07856
  3. polypeptide substr...
  4. KIM docking site c...
  5. activation loop (A...

Protein sequence

>MCA_04647_1
MADFIRTEIFGTCFEITSRYVDLNPVGMGAFGLVCSAKDQLSDQNVAIKKILKPFSTSVLAKRTYRELKLLKQLQHENLI
SLQDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDF
GLARIQDAQMTGYVSTRYYRAPEIMLTWQKYDTEVDIWSAGCIFAEMLEGKPLFPGKDHVHQFSIITELLGSPPTDVIDS
IGSENTLRFVQSLPKREPVPFRQKFKNAADDPHAIDLLEKMLTFDPRKRICAADALAHPYLERYHDPNDEPVAAVKFDWS
FNEADFPIDTWKVMMYSEILDFHKVDPQQMNP

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.