Protein

MCA_04561_1

Length
2,296 amino acids

Gene name: CYR1

Description: Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling.

Browser: contigC:3379853-3386806-

RNA-seq: read pairs 176, FPKM 0.9, percentile rank 9.0% (100% = highest expression)

Protein function

Annotation:CYR1Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling.
KEGG:K01768E4.6.1.1 adenylate cyclase [EC:4.6.1.1]
EGGNOG:0PGS1CYR1Adenylate cyclase
SGD closest match:S000003542CYR1Adenylate cyclase
CGD closest match:CAL0000178292CYR1Adenylate cyclase

Protein alignments

%idAln lengthE-value
MIA_06062_166.62%15820.0MIA_06062_1
A0A0J9X5K6_GEOCN53.46%16330.0Similar to Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase OS=Geotrichum candidum GN=BN980_GECA03s02672g PE=4 SV=1
UniRef50_A0A0J9X5K653.46%16330.0Similar to Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5K6_GEOCN
A0A167FNF3_9ASCO50.25%15920.0Adenylate cyclase OS=Sugiyamaella lignohabitans GN=CYR1 PE=4 SV=1
Q6CE40_YARLI49.71%15550.0YALI0B18759p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B18759g PE=4 SV=1
A0A060T8C0_BLAAD52.03%10110.0ARAD1C28182p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C28182g PE=4 SV=1
A0A1E3PLW2_9ASCO52.52%9310.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82247 PE=4 SV=1
A0A1E4THH8_9ASCO46.37%8260.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2922 PE=4 SV=1
A0A1D8PR83_CANAL47.53%8310.0Adenylate cyclase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CYR1 PE=4 SV=1
CYAA_YEAST40.19%9380.0Adenylate cyclase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYR1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.7637
Predicted cleavage: 94

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Repeat
  4. Repeat
1 500 1000 1500 2000 2296

Detailed signature matches

  1. Domain IPR032675
    Leucine-rich repeat domain, L domain-like
    1. SSF52058 (L domain-...)
    2. G3DSA:3.80.10.10
  2. Domain IPR001932
    PPM-type phosphatase domain
    1. SM00332 (PP2C_4)
    2. G3DSA:3.60.40.10
    3. PF00481 (PP2C)
    4. SSF81606 (PP2C-like)
    5. PS51746 (PPM_2)
  3. Domain IPR029787
    Nucleotide cyclase
    1. SSF55073 (Nucleotid...)
  4. Domain IPR001054
    Adenylyl cyclase class-3/4/guanylyl cyclase
    1. PS50125 (GUANYLATE_...)
    2. G3DSA:3.30.70...
    3. PF00211 (Guanylate_cyc)
    4. SM00044 (cyc_6)
  5. Repeat IPR001611
    Leucine-rich repeat
    1. PF13855 (LRR_8)
    2. PS51450 (LRR)
  6. Repeat IPR003591
    Leucine-rich repeat, typical subtype
    1. SM00369 (LRR_typ_2)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.10.20.90
  2. SM00364 (LRR_bac_2)
  3. SM00365 (LRR_sd22_2)
  4. cd00143 (PP2Cc)
  5. cd01775 (CYR1_RA)
  6. cd07302 (CHD)
  7. mobidb-lite (disord...)

Residue annotation

  1. putative ras inter...
  2. Active site cd00143
  3. nucleotidyl bindin...
  4. metal binding site...
  5. dimer interface cd...

Protein sequence

>MCA_04561_1
MPSPTSTSPKSPNFSRRTPSHHASISSISSKISAGSRHSSHHSNHHHNHQPSPTTPTNPETTTKPNTSSPGNSLATHLNN
SSHRSLSMPNEMPDIQTSTTSNNQRSTPVSQFKYNPNNSAPTQKQKPAQDSLKTTTSNNSLFSPTYLDDTPSLSKVYKST
SNSASNTSLNMPKSGPSGPSSKPSNKPSPMITSTSSRSISQYIHNNSPPPISPNTCNPPSAFLNIRDIEDVSPLSSFSGP
SQEDLTTSGGSSNFKPHSESISSTNTVVPTTSFRANSSAAILESSRFSNEQSLSGTESSPVPTKTPSISSSNNSRRPSYA
SQSSIPRKFEEELNLYSDSASSHSNLMRHASNEWDPVSTDKGFNKPPPMIFPDPEQVFDTRGIQPKPSRSFTSVDFQPND
TQNQINSPSFDARSISSTPASSTKRRSKKSSFLDRFIYRRGSQLDDSDSPLSPSTSLTNSNNNKKCSRHKSTESSGVASS
ASSINQSHNLLHRPSYVLFSSGRHALQYVTQHTEGSTSRLRSSSASRISTPPSQEISPLSDGPSRSNTTTSPTTPLKPTS
SGSPLQTTSSPPGTFYQLDTDLDHMDMDGIVGPSSKPPDAPAPGTIAPPIAPPVGPSAVDKEADWQAPESWSIVPVKKNS
VAPSGSSNTEDKSASTTPKLKPHSNSISARAASAPNQKFCVRIFKENNTFGTSLCHIDITVSDLIALLGKKFFVKSTTGY
QLTVRIAGLTRILQPDETPIVYQTALLEFMGYTEKDRLWEVGRDDLSYLCKFEFSQANIRTITEQEKAIIARDIEHVHIA
RMDLQTIPVFLYSSASKIKYLDVSENPSLTIPSDFIQSCTSLKEIKYVNNQAFEFPVNITLPPALEALDLKRNLISNLDN
IDFTGLRYLTSLDMQGNLLTHIPDSFSQLQSLTFLNLSSNNIKEIPPAICSLRNLVDFDISFNKVSKLPDSIGQLAKLEK
LAISNSYLTKTFPESFTQLVSLKELDIRYNKVQNIDLLSKLPKLEVLYVSKNSITSLDADLSNVKLFYFDRNPITNISLK
TPHTNLTSLNLSKAQMAALPDNLLEMVPLLERLLLDKNHITTIPAKIGNLKNLKYLSLVANLLDSVPPEIGLLYNLTHLD
LHDNNILKLPEEIWNLSSLTYLNVSSNLLDAFPEQITTHSSISSSESERREVSASLSASSTASTTPNNTGTPIIPPNEAR
RPSVLSISSSYDEYKPPAPLKAVNSNPPPILRSPKGFSGSGGDSVMQFPSRRRTSLASSLTTLIMCDNQLTEDCFDELAV
LTSLQVLNLSYNDINEIPLGFLQNLTNLRKLYLSGNNIASLPGDDLESLSGLEVFHMNSNKLHNLPAELGKISTLKVLDV
GSNTLKYNIHNWPYDWNWRFNKDLQYLNFSGNRRLEVNAPNLPNSGYRREVDMSDFTVLSNIRVLGLMDVTLTALSVPDQ
TSNCRVRTFGSEVSSYPYGLADSLGNNNNLSVTDVVLERFRGKDNEILIGLFDGRGSSQIQQGGNKVAKLVQETIGGIFQ
DELKKLREPDETVVDALRRAFLNTNKEIGNTILLPSEEIAHTTIGHRSSTAVDLESKDGMTGSCATLAYITGKKAYFANA
GDSMAIMAHTSGEYSVLTTRHDPTSQVELNRIRSSGGIISSTGQLDGILNVSRAVGFYNLMPNIHANPSILEWDISDGDE
MIIIASKQLWEFVSYQIAVDIARTEKKDLMRAAAKLRDFAIAYGASDKIMVMVLGIGLSKKRPRGGLLNKNFYGNIPNGP
PGAGQLSLVGEIGNEGPFINRADDDYLYSRKRRDKGKDSELARLGGEVEPPQGELAIVFTDIKNSTMLWETHANGMRAAI
KLHNGIMRRQLRLTGGYEVKTEGDAFVVSFPTPTSALLWCLNIQQSLLYADWPAEILETEEGCEILDEKGQLMYRGLSVR
MGIHWGSPVCETDPITRRMDYFGPMVNKAARISAVADGGQITLSSDFVSEMKMLQDRLNSVKEHKMTLFEAFNGDEILGR
SVEQDFKSLESIGWEIKELGEYRLKGLENAEYISLGFPKSLLGRFEHHLLSKKKRNEVRSRYGALSLDSLPKIRQIAVRL
ERICSSLNASFDPDDHYSTDAQMDSPKKTKPNGGGAAKANGPSNARQTTQLGGPLPNNEYEYGQFLDNIITRIENSLSML
YLRTSMYEFTKDDEKFSGAIDFTTILSEALKILGECKKNHQNSQNNDRLVEEVDQNDHNNNNNISSQEEEEEQILSSPTS
FSSLSPLGNPNIKKSLDTQQMTPSLSETSFVTAEEHNVNIIQDDGQTQEFQSLNEN

GO term prediction

Biological Process

GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

Molecular Function

GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016849 phosphorus-oxygen lyase activity

Cellular Component

None predicted.