Protein

MCA_04560_1

Length
417 amino acids

Gene name: CKA1A

Description: Casein kinase II subunit alpha; in S. cerevisiae it has roles in cell growth and proliferation

Browser: contigC:3378276-3379530+

RNA-seq: read pairs 1938, FPKM 57.3, percentile rank 68.3% (100% = highest expression)

Protein function

Annotation:CKA1ACasein kinase II subunit alpha; in S. cerevisiae it has roles in cell growth and proliferation
KEGG:K03097CSNK2A casein kinase II subunit alpha [EC:2.7.11.1]
EGGNOG:0PI5TCKA1casein kinase ii
SGD closest match:S000001297CKA1Casein kinase II subunit alpha
CGD closest match:CAL0000178518CKA1Casein kinase 2 catalytic subunit

Protein alignments

%idAln lengthE-value
MIA_06063_183.00%2472e-153MIA_06063_1
A0A0J9X6R2_GEOCN76.01%2712e-139Similar to Saccharomyces cerevisiae YOR061W CKA2 Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation OS=Geotrichum candidum GN=BN980_GECA03s02683g PE=3 SV=1
UniRef50_I8TJ0372.02%2431e-130Casein kinase II, alpha subunit n=5 Tax=Aspergillus TaxID=5052 RepID=I8TJ03_ASPO3
A0A161HHJ2_9ASCO72.43%2438e-133Casein kinase 2 catalytic subunit CKA2 OS=Sugiyamaella lignohabitans GN=CKA2 PE=3 SV=1
A0A060T2F3_BLAAD71.60%2503e-132ARAD1C28204p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C28204g PE=3 SV=1
A0A1E4TLZ5_9ASCO69.01%2425e-127Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_92635 PE=3 SV=1
A0A1E3PNU0_9ASCO69.55%2437e-126Casein kinase II OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81701 PE=3 SV=1
Q6C8U8_YARLI69.55%2435e-123YALI0D16863p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D16863g PE=3 SV=1
CSK21_YEAST66.39%2416e-115Casein kinase II subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CKA1 PE=1 SV=1
A0A1D8PUA2_CANAL63.79%2434e-115Casein kinase 2 catalytic subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CKA1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1662

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 417

Detailed signature matches

  1. Domain IPR011009
    Protein kinase-like domain
    1. SSF56112 (Protein k...)
  2. Domain IPR000719
    Protein kinase domain
    1. PS50011 (PROTEIN_KI...)
    2. SM00220 (serkin_6)
    3. PF00069 (Pkinase)
  3. SITE IPR008271
    Serine/threonine-protein kinase, active site
    1. PS00108 (PROTEIN_KI...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.51...
  2. G3DSA:3.30.20...
  3. cd14132 (STKc_CK2_a...)
  4. mobidb-lite (disord...)

Residue annotation

  1. tetramer interface...
  2. CK2 beta interface...
  3. allosteric inhibit...
  4. active site cd14132
  5. ATP binding site c...
  6. polypeptide substr...
  7. activation loop (A...

Protein sequence

>MCA_04560_1
MSMSIARVYADYNQQMPSSYWDYEHVKINWGNQACYEIIRKVGRGKYSEAFEGLNLAAIGANYPAGASGSESMSSSMSSL
QRIQKIRDNELSETDASAEDLNNRNNITNSISNNNNNNITNSNNNSLSSNNNGSCKKPAPMFGESCVIKVLKPVRKKKIK
REIKILQNLAGGTNIITLLDVVRDPTSKTPSLIFEYVNNTDFRVLYPKFTNYDIKYYMFELLKALDFCHSKGIMHRDVKP
HNIMIDHEQRKLRLIDWGLAEFYHPGMTYNVRVASRCYKGPELLVDFQMYDYSLDLWSLGTVLASLIFKIDPFFHGTSNT
NQLIKIAQVLGTDDLLEYLRRYEIKLPSEYDNILGRYKRQSWQSFIKENNKKYATPLAIDLIDKLLRYDHKERLTAQEAM
DHPYFDEVRDLLTQGQR

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.