Protein
MCA_04472_1
Length
928 amino acids
Gene name: KU80
Description: ATP-dependent DNA helicase II subunit 2
Browser: contigC:3131761-3134812-
RNA-seq: read pairs 1296, FPKM 17.2, percentile rank 37.4% (100% = highest expression)
Protein function
| Annotation: | KU80 | ATP-dependent DNA helicase II subunit 2 | |
|---|---|---|---|
| KEGG: | K10885 | XRCC5 | ATP-dependent DNA helicase 2 subunit 2 |
| EGGNOG: | 0PK4Q | KU80 | Single stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70 ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity) |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02810_1 | 30.33% | 811 | 2e-84 | MIA_02810_1 |
| A0A0J9X5D8_GEOCN | 25.61% | 742 | 1e-42 | Similar to Saccharomyces cerevisiae YMR106C YKU80 Subunit of the telomeric Ku complex (Yku70p-Yku80p) OS=Geotrichum candidum GN=BN980_GECA03s00791g PE=4 SV=1 |
| UniRef50_A0A0J9X5D8 | 25.61% | 742 | 2e-39 | Similar to Saccharomyces cerevisiae YMR106C YKU80 Subunit of the telomeric Ku complex (Yku70p-Yku80p) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X5D8_GEOCN |
| KU80_YARLI | 23.13% | 804 | 2e-35 | ATP-dependent DNA helicase II subunit 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=KU80 PE=3 SV=1 |
| A0A1E3PQT8_9ASCO | 23.43% | 734 | 4e-26 | SPOC domain-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_76203 PE=4 SV=1 |
| A0A060TCM3_BLAAD | 22.54% | 732 | 6e-20 | ARAD1D37246p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D37246g PE=4 SV=1 |
| A0A167EC69_9ASCO | 22.04% | 558 | 2e-14 | Yku80p OS=Sugiyamaella lignohabitans GN=YKU80 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1273
Protein family membership
None predicted.
Domains and repeats
-
Domain
-
Domain
1
100
200
300
400
500
600
700
800
928
Detailed signature matches
no IPR
Unintegrated signatures
-
-
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mobidb-lite (disord...)
Protein sequence
>MCA_04472_1 MSKEVTYFLIDLNPTMGKCHNGRTTSDLQWAMQYAYDIISDKIISLRKTDQVAIYGFNRKDELEEIIPLKQFFPSDVKSA QAQLFCADEDLAVQCNYVLDAASEVIDKIALHCRQLKYIKNLVLITNCREPLIDQEQELTSSVFPADKYLQSESDEDDEI LAKTQLVQDSVEKLEPSKLVMDDIVQVCSKISANNINFKVIGIDLDDFERGYVEKSEKEIKKFNNELLLLKMNLVFNQDK VEGLGNIIIGNAEEAIMSLAYPRIKKFRVQKSYSAVLSLGLKALDNENEEDGIRNATVSNSGRSIAISVEVYSSVRKANP PRTVATTKRQNKGSYIAGELGTKELTEIQYSTEYYLLDNKSDVSQDPAPVENTPVFFDDENGMTASGYEKQEHLREYIED GEKITEKMLSTNKKEFGYRLGNEVAMLGENEISLLSEISKGNYSNKLPSSFENTRLIELIGFIPNSKASRWMGMSPSDYI VSNKDEVESALALSSLVHSLYEYESFAIARSNATSGGTGTAGLKGGPEINLLIPYIEEEFEALVMVRLPFADDIRGLMFP PLGYLIKKPKTDNDAGSDDESTTITRKEKEEDIIIDEHDTLLPNQEIQEAMDQLVDDMDLMEKGAPIETEDGDDEERQEW GIPEEIKNPVLHRFKQIAKYYSINSMLREENKPLFEASRDLEVPDFIPSLLEHMTPPEEIKSKLESNSLANRLERLLEIK PRETKKRRRVDDDDEEDNKTNKVIQQAIDIDGLLEEVCDKPKEQDSETSKSMIKTEDSNSIKEEPKEIGLDIRIAKQEDI KFSSDLTSTVLVDETPKSLYESSKEQLDFITTSEISSKNVQSILDQFLERLEDVIEKVDNTSSLMATSGSVVEDVNEVVT FLEKQLGVLKSNTDVNDLLQNDSDMLQSIADVKEWINDTKDEVKKYLK
GO term prediction
Biological Process
GO:0006303 double-strand break repair via nonhomologous end joining
Molecular Function
GO:0003677 DNA binding
Cellular Component
None predicted.