Protein

MCA_04435_1

Length
1,233 amino acids

Gene name: SMC3

Description: Structural maintenance of chromosomes protein 3

Browser: contigC:3042185-3046086+

RNA-seq: read pairs 1128, FPKM 11.3, percentile rank 28.0% (100% = highest expression)

Protein function

Annotation:SMC3Structural maintenance of chromosomes protein 3
KEGG:K06669SMC3 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)
EGGNOG:0PHGYSMC3Chromosome segregation protein
SGD closest match:S000003610SMC3Structural maintenance of chromosomes protein 3
CGD closest match:CAL0000193720SMC3Structural maintenance of chromosomes protein

Protein alignments

%idAln lengthE-value
A0A0J9XBR7_GEOCN52.03%12340.0Structural maintenance of chromosomes protein OS=Geotrichum candidum GN=BN980_GECA07s02122g PE=3 SV=1
MIA_03652_151.21%12380.0MIA_03652_1
UniRef50_A0A1E3Q5T145.90%12310.0Structural maintenance of chromosomes protein n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A1E3Q5T1_LIPST
A0A1E3PLP0_9ASCO45.22%12450.0Structural maintenance of chromosomes protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50270 PE=3 SV=1
Q6CI88_YARLI40.21%12460.0Structural maintenance of chromosomes protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A00616g PE=3 SV=1
A0A060TGN9_BLAAD40.93%11580.0ARAD1D32186p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D32186g PE=4 SV=1
A0A167DW74_9ASCO40.58%11630.0Cohesin subunit SMC3 OS=Sugiyamaella lignohabitans GN=SMC3 PE=4 SV=1
A0A1D8PJK7_CANAL38.36%12800.0Structural maintenance of chromosomes protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC3 PE=3 SV=1
SMC3_YEAST35.78%12660.0Structural maintenance of chromosomes protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC3 PE=1 SV=1
A0A1E4TK84_9ASCO34.70%12450.0Structural maintenance of chromosomes protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_42779 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1632
Predicted cleavage: 35

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1233

Detailed signature matches

  1. Family IPR024704
    Structural maintenance of chromosomes protein
    1. PIRSF005719 (SMC)
  2. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  3. Domain IPR003395
    RecF/RecN/SMC, N-terminal
    1. PF02463 (SMC_N)
  4. Domain IPR010935
    SMCs flexible hinge
    1. PF06470 (SMC_hinge)
    2. SM00968 (SMC_hinge_2)
    3. SSF75553 (Smc hinge...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.28...
  3. G3DSA:1.20.12...
  4. G3DSA:1.20.5.170
  5. G3DSA:1.20.5.340
  6. G3DSA:3.40.50...
  7. cd03272 (ABC_SMC3_euk)
  8. mobidb-lite (disord...)

Residue annotation

  1. Walker A/P-loop cd...
  2. ATP binding site c...
  3. Q-loop/lid cd03272

Protein sequence

>MCA_04435_1
MYIKQITIQGFKSYKNQTITDPFSPHHNVVVGRNGSGKSNFFAAIRFVLNDGDVYHNMNREFRQSLLHEGSGSGIVTAYV
EIAIDNSDNRFVGYSDTVTIRRTVGVKKDEYSIDRKSATRNDVKSLLESGGFSQSNPYYIVPQGRVTALTNAKDSERLEL
LKEVAGTKVYDDRRAESIKVLNESEIKHKTIEESLQFIRERLEELEKEKEELKEYQVIDRQKRSLDYTLLDRELQEINET
LESLKEERENGIALNNQRLEQFNSLEEHVNEIESTLSKLKNDTRLLGVERARLKQELKLKIKDKARREVECDQLERSAAS
SREAIAQKRQEISNLTQLITDKKAEFDSIQPQLLELKAREQELRQEVQNLESAKNILLSKQGRNYRFNSQQERDLWLQNE
LAGLSSNIAELESVNSSSKKSLADLEQQLAAVRSSIDEIKAQGNSKAQLLKQQQELLDEAESEYLALDNERKSLWSEEQR
ANSVLENLQDDIKQSQRAAFSTLSRAQSSGLKAVKRISNKLGLNGVYGTIAELIDVAPEFKLATEITAGNSLLHVVVDDE
ETASKIMAELLREKSGRVTFMPLNRLSPRTPNYPTSDDVTPLINHLQYDQIFDPAVRQIFGNTIVVRNLEMGSQIAHNND
LNAITLEGDRVNTKGVMTGGFYNIRKSRLTAFQKLKEMNDLFSVKEEEYRTIQKRIRELDERINQSRSNKYKIESEIQTL
RNSLSPLNNLRQSKTIEESQIKEMIQEVQQSIQDSEINIQNYTNQKNSYLAELQSPFDQVLSDEEIQQLREINQQLPRKV
KQLNDLSMERLNIEQRSTQLDVEIHQDLEFRVEQLTSSLENNALDEDDEMPQDLGGRDPGHALTLARQQLQNLVENIASI
EEKLESLEADIERSNAEIAETEKQLSIATETRFKIGRSIESLHKQMEKSIAKNTLLTERHDEVQRKIRELGVLPPNAFTE
FEGTPSEQIVNKLRKISDKLKKFSHVNKKAVEQYNNFTKQEEKLEDRKRELETSHESIEQLIHTLDMRKDEAIDRTFKQV
SKAFTEIFEKLVPGGKGELIMRRKHDAVNGNNRGNDYESGSDDEEEAQEQQTRRRGNRNPRNTIVSVDSYVGVGISVSFN
SKEDDQQRIEQLSGGQKSLCALTLIFAIQQSDPAPFYLFDEIDANLDTQYRTSVAAMIHELARSAQFICTTFRPEMLQVA
DKFYGVSFENRMSTISTIDKEHALTFIEGYQAR

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome