MCA_04397_1

Protein

Length

1,464 amino acids

Gene name: STE20

Description: Serine/threonine-protein kinase Ste20; in S. cerevisiae it is involved in Cdc42p-activated signal transduction pathway; in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptak.

Browser: contigC:2883316-2888058+

RNA-seq: read pairs 1975, FPKM 16.7, percentile rank 36.6% (100% = highest expression)

Protein function

Annotation:		STE20	Serine/threonine-protein kinase Ste20; in S. cerevisiae it is involved in Cdc42p-activated signal transduction pathway; in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptak.
KEGG:	K04409	PAK1	p21-activated kinase 1 [EC:2.7.11.1]
EGGNOG:	0PGP3	STE20	serine threonine-protein kinase
SGD closest match:	S000000999	STE20	Serine/threonine-protein kinase STE20
CGD closest match:	CAL0000198103	CST20	Serine/threonine-protein kinase CST20

Protein alignments

	%id	Aln length	E-value
A0A0J9X7V4_GEOCN	82.57%	327	6e-176	Similar to Saccharomyces cerevisiae YHL007C STE20 Cdc42p-activated signal transducing kinase of the PAK (P21-activated kinase) family OS=Geotrichum candidum GN=BN980_GECA04s06214g PE=4 SV=1
UniRef50_A0A0J9X7V4	82.57%	327	1e-172	Similar to Saccharomyces cerevisiae YHL007C STE20 Cdc42p-activated signal transducing kinase of the PAK (P21-activated kinase) family n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7V4_GEOCN
A0A167DPV5_9ASCO	76.40%	322	2e-161	Mitogen-activated protein kinase kinase kinase kinase STE20 OS=Sugiyamaella lignohabitans GN=STE20 PE=4 SV=1
A0A060T898_BLAAD	77.44%	328	4e-163	ARAD1C35046p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C35046g PE=4 SV=1
MIA_03434_1	80.00%	290	8e-158	MIA_03434_1
STE20_YARLI	78.11%	297	2e-158	Serine/threonine-protein kinase STE20 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=STE20 PE=3 SV=1
STE20_YEAST	73.79%	290	2e-144	Serine/threonine-protein kinase STE20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STE20 PE=1 SV=1
A0A1E4TI70_9ASCO	69.67%	300	1e-147	Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_18692 PE=4 SV=1
STE20_CANAL	69.46%	298	1e-139	Serine/threonine-protein kinase CST20 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CST20 PE=3 SV=1
A0A1E3PGH3_9ASCO	71.66%	307	3e-149	Pkinase-domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_26587 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2120

Protein family membership

None predicted.

Domains and repeats

Domain
679 - 735
CRIB domain (IPR000095)
p21 activated kinase binding domain (IPR033923)
1,176 - 1,441
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 200 400 600 800 1000 1200 1464

Detailed signature matches

IPR000095

CRIB domain
1. G3DSA:3.90.81...
  
  679 - 720
  
  GENE3D
  G3DSA:3.90.810.10 (G3DSA:3.90.810.10)
2. PF00786 (PBD)
  
  679 - 735
  
  Pfam
  PF00786 (PBD)
3. SM00285 (PBD_5)
  
  680 - 715
  
  SMART
  SM00285 (PBD_5)
IPR033923

p21 activated kinase binding domain
1. cd01093 (CRIB_PAK_like)
  
  683 - 723
  
  CDD
  cd01093 (CRIB_PAK_like)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  1,176 - 1,441
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. PS50011 (PROTEIN_KI...)
  
  1,185 - 1,436
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
2. SM00220 (serkin_6)
  
  1,185 - 1,436
  
  SMART
  SM00220 (serkin_6)
3. PF00069 (Pkinase)
  
  1,185 - 1,436
  
  Pfam
  PF00069 (Pkinase)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  1,191 - 1,214
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  1,300 - 1,312
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

Coil

1,455 - 1,464

COILS
Coil (Coil)

1,044 - 1,131

COILS
Coil (Coil)
G3DSA:1.10.51...

1,399 - 1,438

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)

1,251 - 1,398

GENE3D
G3DSA:1.10.510.10 (G3DSA:1.10.510.10)
G3DSA:1.20.58.60

721 - 1,133

GENE3D
G3DSA:1.20.58.60 (G3DSA:1.20.58.60)
G3DSA:3.30.20...

1,168 - 1,250

GENE3D
G3DSA:3.30.200.20 (G3DSA:3.30.200.20)
cd06614 (STKc_PAK)

1,184 - 1,437

CDD
cd06614 (STKc_PAK)
mobidb-lite (disord...)

285 - 317

MobiDB Lite
mobidb-lite (disorder_prediction)

756 - 944

MobiDB Lite
mobidb-lite (disorder_prediction)

496 - 676

MobiDB Lite
mobidb-lite (disorder_prediction)

440 - 477

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 60

MobiDB Lite
mobidb-lite (disorder_prediction)

956 - 1,026

MobiDB Lite
mobidb-lite (disorder_prediction)

166 - 269

MobiDB Lite
mobidb-lite (disorder_prediction)

75 - 101

MobiDB Lite
mobidb-lite (disorder_prediction)

1,113 - 1,164

MobiDB Lite
mobidb-lite (disorder_prediction)

125 - 150

MobiDB Lite
mobidb-lite (disorder_prediction)

346 - 425

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

GTPase interaction...

683P

GTPase interaction site
683P, 686M, 688I, 691H, 708W, 712L
CDD
cd01093 (CRIB_PAK_like)

686M

GTPase interaction site
683P, 686M, 688I, 691H, 708W, 712L
CDD
cd01093 (CRIB_PAK_like)

688I

GTPase interaction site
683P, 686M, 688I, 691H, 708W, 712L
CDD
cd01093 (CRIB_PAK_like)

691H

GTPase interaction site
683P, 686M, 688I, 691H, 708W, 712L
CDD
cd01093 (CRIB_PAK_like)

708W

GTPase interaction site
683P, 686M, 688I, 691H, 708W, 712L
CDD
cd01093 (CRIB_PAK_like)

712L

GTPase interaction site
683P, 686M, 688I, 691H, 708W, 712L
CDD
cd01093 (CRIB_PAK_like)
ATP binding site c...

1,191I

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,192G

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,193Q

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,194G

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,195A

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,199V

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,212A

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,214K

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,243V

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,259M

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,260E

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,261Y

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,262M

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,263E

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,265G

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,266S

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,269D

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,308D

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,309N

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,311L

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,321T

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)

1,322D

ATP binding site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D
CDD
cd06614 (STKc_PAK)
active site cd06614

1,191I

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,192G

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,193Q

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,194G

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,195A

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,199V

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,212A

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,214K

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,243V

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,259M

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,260E

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,261Y

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,262M

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,263E

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,265G

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,266S

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,269D

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,304D

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,306K

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,307S

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,308D

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,309N

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,311L

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,321T

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,322D

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,325F

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,338T

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,339M

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,340V

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,341G

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,342T

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,344Y

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,371E

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,380L

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,381N

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,382E

active site
1,191I, 1,192G, 1,193Q, 1,194G, 1,195A, 1,199V, 1,212A, 1,214K, 1,243V, 1,259M, 1,260E, 1,261Y, 1,262M, 1,263E, 1,265G, 1,266S, 1,269D, 1,304D, 1,306K, 1,307S, 1,308D, 1,309N, 1,311L, 1,321T, 1,322D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)
polypeptide substr...

1,194G

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,195A

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,304D

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,306K

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,307S

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,308D

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,325F

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,338T

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,339M

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,340V

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,341G

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,342T

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,344Y

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,371E

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,380L

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,381N

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)

1,382E

polypeptide substrate binding site
1,194G, 1,195A, 1,304D, 1,306K, 1,307S, 1,308D, 1,325F, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,344Y, 1,371E, 1,380L, 1,381N, 1,382E
CDD
cd06614 (STKc_PAK)
activation loop (A...

1,321T

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,322D

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,323F

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,324G

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,325F

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,326C

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,327A

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,328R

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,329I

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,330N

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,331E

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,332S

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,337T

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,338T

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,339M

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,340V

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,341G

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,342T

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,343P

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

1,344Y

activation loop (A-loop)
1,321T, 1,322D, 1,323F, 1,324G, 1,325F, 1,326C, 1,327A, 1,328R, 1,329I, 1,330N, 1,331E, 1,332S, 1,337T, 1,338T, 1,339M, 1,340V, 1,341G, 1,342T, 1,343P, 1,344Y
CDD
cd06614 (STKc_PAK)

Protein sequence

>MCA_04397_1
MTTALSKNTNSSNNNNNSSSSSSSSHHHHPHNFNTVSNNNSNSKDNNHLDFDFSSSTTSPHSFTLEEIKLQPSNRFNFSS
EPSEHQTTRSTTVVNSSNNSKSFDIQHNKNINNLLNLSFENTNNTNNDSTINSQSTLKMNSQSNSSSNYQGLQEGITFSN
IFSSSSHHHPYSNNNTAGSLQNKSKFNNSSTDINRSQTTIIDTDPSSSDDNDDPYLDQNSIYEEYEDSPKYSVQQQQYKV
QHNQPSSPKNYANPPPSSSGHSTIMSNNHYNQSKIPQENINLNLNNTYPQHYTTTDSSINNNNNNNNSNSFYSQNIPATP
TAMQSNQFVNSPASVKTTVPSSPTIIDFPSVNNNNTNNNTYNSSSSSNNNQPQAYTKQSPNKPSSKILQRLSNQHSSPQN
TRKSSSGDYSSNYPSGGSTPPIPMKSAERTLSHLSSFSISSSTSANSYNQDGINQYSTSNPNLQNTLSNSTDFPSPVTPQ
LQILEQFQSSSALSYEYKTPNNNNNNINNSSRPTTSTTVQTPSTATSRSSRGSNQWQPMKQPSQTASAEYLSNSSKPNDS
STHSSSTAPSTSSPSAIDLSNLKDIPFPQESSSGSSSLISSPAVNQNYSLSPSDRNNSMPAFDNGNKRRSGRARSKTMKG
VISNFVNSMRGGEQGNSSRRVSGNSDYGSNSSSSSGIIKISEPYDMKIVTHVGVDYDTGEFTGMPKEWEKMLADGGISKR
EVEQHPQAVRDVMNFLTNADQEQTIWKKFDKAKVGNGSSPPLKLDSSAFQTPLTTPGLASPMSSAGNGGGDYFTAVRPAP
PVPKTSDSTNGHADSRSRSNSILDGLRKKDSSNRLRSGSVKELAHSLRKRSDSIKEEISAPQVIGERQFIPTRPAPKPPG
SPQSPVSSSHNVSPGTATSVPLPQELRYDNNNNANSLANQFSPQSTTHSINNSNNTGRSSNPAANLKIDLSKSSNANISS
SVSTPTSISASKKNPPHPASPPPRPPPAPPLGVPSVRSNRDERQTSGGSIGSNGPNGMSGMDPSFFSPLQQQHLTRTQAP
QQSSQQQQQQQQQQQQQQQQQQQQQQQQQRRLQQQQQEQLLQQRQLLQQQQQQQQRRLEQQQQQQQQHAAQMELARQNQQ
QQEQLLQMQQATQGAVGGAIQPTPAANSRDPQSAARRREARRRRDMEVLNQLNRICNPEDPSNKYTNLRKIGQGASGGVY
TATEVSNNRCVAIKQMNLEQQPKKELIINEIIVMRESSHKNIVNFIDSYLLSGDLWVVMEYMEGGSLTDVVTYNMMTEGQ
IGAVCREVLQGLEHLHDQGVIHRDIKSDNILLSMRGDIKLTDFGFCARINESNSKRTTMVGTPYWMAPEVVSRKEYGPKI
DIWSLGIMAIEMIEGEPPYLNESPIRALYLIVTNGTPRLKDPGSLSQVFTEFLNWSLKVDVEQRATASELLQHDFLKTAD
SVRNLAPLVKAARMAKLAEQNNSN

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Cellular Component