Protein
MCA_04251_1
Length
759 amino acids
Gene name: MEF1
Description: Elongation factor G, mitochondrial
Browser: contigC:2492122-2494402+
RNA-seq: read pairs 2127, FPKM 34.6, percentile rank 56.7% (100% = highest expression)
Protein function
Annotation: | MEF1 | Elongation factor G, mitochondrial | |
---|---|---|---|
KEGG: | K02355 | fusA | elongation factor G |
EGGNOG: | 0PGGK | MEF1 | Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) |
SGD closest match: | S000004059 | MEF1 | Elongation factor G, mitochondrial |
CGD closest match: | CAL0000175777 | MEF1 | Elongation factor G, mitochondrial |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MIA_02192_1 | 83.06% | 744 | 0.0 | MIA_02192_1 |
A0A0J9X7Y3_GEOCN | 77.37% | 760 | 0.0 | Elongation factor G, mitochondrial OS=Geotrichum candidum GN=MEF1 PE=3 SV=1 |
A0A060SXB9_BLAAD | 77.32% | 723 | 0.0 | Elongation factor G, mitochondrial OS=Blastobotrys adeninivorans GN=MEF1 PE=3 SV=1 |
A0A167EQ65_9ASCO | 75.67% | 744 | 0.0 | Elongation factor G, mitochondrial OS=Sugiyamaella lignohabitans GN=MEF1 PE=3 SV=1 |
EFGM_YEAST | 73.10% | 736 | 0.0 | Elongation factor G, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MEF1 PE=1 SV=2 |
UniRef50_P25039 | 73.10% | 736 | 0.0 | Elongation factor G, mitochondrial n=350 Tax=cellular organisms TaxID=131567 RepID=EFGM_YEAST |
A0A1E4TJ74_9ASCO | 73.74% | 712 | 0.0 | Elongation factor G, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=MEF1 PE=3 SV=1 |
EFGM_YARLI | 70.52% | 736 | 0.0 | Elongation factor G, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MEF1 PE=3 SV=1 |
A0A1E3PE22_9ASCO | 74.19% | 713 | 0.0 | Elongation factor G, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=MEF1 PE=3 SV=1 |
EFGM_CANAL | 71.60% | 729 | 0.0 | Elongation factor G, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MEF1 PE=3 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9730
Predicted cleavage: 36
Protein family membership
- Translation elongation factor EFG/EF2 (IPR004540)
Domains and repeats
-
Domain
-
Domain
1
100
200
300
400
500
600
700
759
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
G1 box cd01886
-
putative GEF inter...
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GTP/Mg2+ binding s...
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Switch I region cd...
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G2 box cd01886
-
G3 box cd01886
-
Switch II region c...
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G4 box cd01886
-
G5 box cd01886
Protein sequence
>MCA_04251_1 MSFRIATSYWGKSVARSANPLAALKSCFSTSAARLRTYEEEKVIIDELKSKMPAEEMARLQTLRNIGISAHIDSGKTTFT ERVLYYTGRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATYCDWTRKLPDGTGKDYHFNLIDTPGHIDFTIEVERA LRVLDGAVLVLCAVSGVQSQTITVDRQMRRYNVPRITFINKMDRMGANPWKAIDQVQKKLKIQAAAIQVPIGAEDHLEGV VDIIDEVAIYNKGDQGEKVVYTKEIPEDLKDLVAEKRALLIETLADVDDEIAEIFLEEQTPTPQQIKDAIRRATIARKFS PVLMGSALANRGIQPVLDAICDYLPNPSDILNTGLDIAKNEAPVVMTPYQSAPFVGLAFKLEEGKYGQLTYVRVYQGKLK KGMNIVNVKTGKRTKLARLARMHSEEMEDVDEIGAGEICATFGVDCSSGDTFTDGEVQYTMTSMFVPDPVISLSISPKTK DANFSKAINRFQKEDPTFVVKFDPESKETVISGMGELHLEIYVERMRREYNVDCVTGRPQVAYRETITTQVPFDYTHKKQ SGGAGQYAKVMGLMGPASVPDKNEFETQIVGGKIPDKFLYACQKGFNEACEKGPLTGHKVLGVNMLINDGQIHIVDSSEI SFKTATEAAFKQAFAKANPIILEPIMEVGLTAPIEFQGSIIGLLNKRMATINSTDVGSDEFTISAECSLNNMFGFASHLR AATQGKGEFSLEFKHYAPTPPQLQRELIAAFEKKQNAKK
GO term prediction
Biological Process
GO:0006414 translational elongation
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Cellular Component
GO:0005622 intracellular