MCA_04199_1

Protein

Length

1,115 amino acids

Gene name: SMC5

Description: Structural maintenance of chromosomes protein 5

Browser: contigC:2325482-2328830-

RNA-seq: read pairs 864, FPKM 9.6, percentile rank 25.3% (100% = highest expression)

Protein function

Annotation:		SMC5	Structural maintenance of chromosomes protein 5
EGGNOG:	0PGSX	SMC5	Structural maintenance of
SGD closest match:	S000005394	SMC5	Structural maintenance of chromosomes protein 5
CGD closest match:	CAL0000199747	SMC5	DNA repair ATPase

Protein alignments

	%id	Aln length	E-value
UniRef50_A0A1E3QES8	33.79%	1092	1e-173	Uncharacterized protein n=1 Tax=Lipomyces starkeyi NRRL Y-11557 TaxID=675824 RepID=A0A1E3QES8_LIPST
MIA_02634_1	41.46%	644	4e-144	MIA_02634_1
A0A0J9X8A4_GEOCN	38.32%	668	4e-129	Similar to Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein OS=Geotrichum candidum GN=BN980_GECA04s03233g PE=4 SV=1
SMC5_YEAST	28.23%	1144	2e-110	Structural maintenance of chromosomes protein 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC5 PE=1 SV=1
A0A1E3PGQ6_9ASCO	31.42%	662	2e-90	p-loop containing nucleoside triphosphate hydrolase protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_9252 PE=4 SV=1
Q59UE8_CANAL	28.30%	675	8e-67	DNA repair ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC5 PE=4 SV=1
A0A167E2E0_9ASCO	59.26%	162	4e-57	DNA repair ATPase SMC5 OS=Sugiyamaella lignohabitans GN=SMC5 PE=4 SV=1
A0A060T412_BLAAD	52.36%	212	4e-57	ARAD1A13508p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A13508g PE=4 SV=1
A0A1E4TDV6_9ASCO	51.49%	202	1e-54	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1669 PE=4 SV=1
Q6C5K8_YARLI	23.73%	649	2e-41	YALI0E17193p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E17193g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0537
Predicted cleavage: 16

Protein family membership

None predicted.

Domains and repeats

Domain
38 - 1,061
RecF/RecN/SMC, N-terminal (IPR003395)
Domain
38 - 191
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
971 - 1,064
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 200 400 600 800 1000 1115

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  971 - 1,064
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  38 - 191
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR003395

RecF/RecN/SMC, N-terminal
1. PF02463 (SMC_N)
  
  38 - 1,061
  
  Pfam
  PF02463 (SMC_N)

no IPR

Unintegrated signatures

Coil

747 - 767

COILS
Coil (Coil)

392 - 412

COILS
Coil (Coil)

269 - 310

COILS
Coil (Coil)

325 - 373

COILS
Coil (Coil)

902 - 936

COILS
Coil (Coil)

213 - 246

COILS
Coil (Coil)

661 - 740

COILS
Coil (Coil)
G3DSA:1.20.12...

282 - 439

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)

643 - 775

GENE3D
G3DSA:1.20.120.330 (G3DSA:1.20.120.330)
G3DSA:3.40.50...

37 - 254

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

776 - 1,093

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd03277 (ABC_SMC5_euk)

979 - 1,083

CDD
cd03277 (ABC_SMC5_euk)

36 - 184

CDD
cd03277 (ABC_SMC5_euk)

Residue annotation

Walker A/P-loop cd...

65G

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

66P

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

67N

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

68G

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

69T

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

70G

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

71K

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)

72S

Walker A/P-loop
65G, 66P, 67N, 68G, 69T, 70G, 71K, 72S
CDD
cd03277 (ABC_SMC5_euk)
ATP binding site c...

68G

ATP binding site
68G, 69T, 71K, 72S, 73T, 168Q
CDD
cd03277 (ABC_SMC5_euk)

69T

ATP binding site
68G, 69T, 71K, 72S, 73T, 168Q
CDD
cd03277 (ABC_SMC5_euk)

71K

ATP binding site
68G, 69T, 71K, 72S, 73T, 168Q
CDD
cd03277 (ABC_SMC5_euk)

72S

ATP binding site
68G, 69T, 71K, 72S, 73T, 168Q
CDD
cd03277 (ABC_SMC5_euk)

73T

ATP binding site
68G, 69T, 71K, 72S, 73T, 168Q
CDD
cd03277 (ABC_SMC5_euk)

168Q

ATP binding site
68G, 69T, 71K, 72S, 73T, 168Q
CDD
cd03277 (ABC_SMC5_euk)
Q-loop/lid cd03277

165F

Q-loop/lid
165F, 166L, 167P, 168Q
CDD
cd03277 (ABC_SMC5_euk)

166L

Q-loop/lid
165F, 166L, 167P, 168Q
CDD
cd03277 (ABC_SMC5_euk)

167P

Q-loop/lid
165F, 166L, 167P, 168Q
CDD
cd03277 (ABC_SMC5_euk)

168Q

Q-loop/lid
165F, 166L, 167P, 168Q
CDD
cd03277 (ABC_SMC5_euk)
ABC transporter si...

999Q

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,000S

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,001G

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,002G

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,003E

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,004R

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,005A

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,006V

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,007S

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)

1,008T

ABC transporter signature motif
999Q, 1,000S, 1,001G, 1,002G, 1,003E, 1,004R, 1,005A, 1,006V, 1,007S, 1,008T
CDD
cd03277 (ABC_SMC5_euk)
Walker B cd03277

1,023F

Walker B
1,023F, 1,024R, 1,025V, 1,026V, 1,027D, 1,028E
CDD
cd03277 (ABC_SMC5_euk)

1,024R

Walker B
1,023F, 1,024R, 1,025V, 1,026V, 1,027D, 1,028E
CDD
cd03277 (ABC_SMC5_euk)

1,025V

Walker B
1,023F, 1,024R, 1,025V, 1,026V, 1,027D, 1,028E
CDD
cd03277 (ABC_SMC5_euk)

1,026V

Walker B
1,023F, 1,024R, 1,025V, 1,026V, 1,027D, 1,028E
CDD
cd03277 (ABC_SMC5_euk)

1,027D

Walker B
1,023F, 1,024R, 1,025V, 1,026V, 1,027D, 1,028E
CDD
cd03277 (ABC_SMC5_euk)

1,028E

Walker B
1,023F, 1,024R, 1,025V, 1,026V, 1,027D, 1,028E
CDD
cd03277 (ABC_SMC5_euk)
ATP binding site c...

1,027D

ATP binding site
1,027D, 1,028E, 1,062P
CDD
cd03277 (ABC_SMC5_euk)

1,028E

ATP binding site
1,027D, 1,028E, 1,062P
CDD
cd03277 (ABC_SMC5_euk)

1,062P

ATP binding site
1,027D, 1,028E, 1,062P
CDD
cd03277 (ABC_SMC5_euk)
D-loop cd03277

1,031Q

D-loop
1,031Q, 1,032G, 1,033M, 1,034D
CDD
cd03277 (ABC_SMC5_euk)

1,032G

D-loop
1,031Q, 1,032G, 1,033M, 1,034D
CDD
cd03277 (ABC_SMC5_euk)

1,033M

D-loop
1,031Q, 1,032G, 1,033M, 1,034D
CDD
cd03277 (ABC_SMC5_euk)

1,034D

D-loop
1,031Q, 1,032G, 1,033M, 1,034D
CDD
cd03277 (ABC_SMC5_euk)
H-loop/switch regi...

1,058F

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

1,059L

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

1,060I

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

1,061T

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

1,062P

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

1,063K

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

1,064L

H-loop/switch region
1,058F, 1,059L, 1,060I, 1,061T, 1,062P, 1,063K, 1,064L
CDD
cd03277 (ABC_SMC5_euk)

Protein sequence

>MCA_04199_1
MAPTIRKIEYSEDDYPSKRIKHSTSNARSSDGYEPGAIRRIILENFVTYHHVEYTIGPSLNMIIGPNGTGKSTIVCAICL
GLGGKPDILGRARSPAEFIKNGYESATITLELQNTGSDASVVKISRTITKNGSSSWRIGNRPSTQKEIQKIVNTFNIQID
NLCQFLPQDRVASFAKIHPTELLIETERAVGSLGMVEKHKKLIELDEVRTVDVDTLKHEEERLEQMNKLQEEDREILERM
EEHKKNQNRLKVLDALIPSLKHRKARQVRAFAKMEYDKLLQRKQELYEQKEQLKKQQLIYEEKASELDESYRSLNIEKKS
LSQHNGQTLREIDTLNDEIKTTQAEMKELLMKRERRKDHIKQVEDRIAELEGVLENQPEPDKNRYIELGERIALKKDEKR
NIEARVQQLRRNKETVEEPLHTKRSELRKREQQMSDLQSVEAYRLHYLENNRGREFKVVAAAIKWLRKNKDMFKEPIYEP
PVMCLEFKDPKMTHIISAAIDKNSMLAFTACNREDYDLLAHELIDKQHINVAIREYSRTNIPTLDKQPMSMSRNELKSYG
FEGYVIDLLDGPAPVLNMLCHSSKINQIPYSAQILTTNQLNRINATLKPSGEPMFFKYMDRKNLMANIRSRYGRRLMSCK
TDTLAKAAPYIITTGASEQDIEAAQGEIRELIKEIQKIESNSSSIEEKINEVSQEITEIQHYISQYEEERKEYQKKSSII
LKLKNKIADFRLQLEDLRAQEDDSAAFDKLEKTLNQLCRQLKKLYTMATDSLNVWLEVARKARTVYIEKTTALGAAQWLK
IQTERGTEEITERIYAQECKLETLAVEIATLKELVQEKTNGMPNELKNEIKSLHSDPSDLEDPAFPAYINDRITQFDNEL
NQLKYLISSAQDHGGEAAQKRYEEREVEIQALTLEIESIRRRNENYEGEIAQIRETWEPELERMVETISTEFSKAFEFIK
CKGKVRLGNRDLPFKDWCIEILVSFRQDSELQVLTHQRQSGGERAVSTIFYLISLQTITKSPFRVVDEINQGMDPRNERI
VHHHMVQVACAENSSQYFLITPKLLQDLEYHPRMKIHMIFSGSKVEDVSNYEEPPSHSATLLRNMIANGVGAGTG

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

MCA_04199_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component