Protein

MCA_04178_1

Length
1,554 amino acids

Gene name: REV3

Description: DNA polymerase zeta catalytic subunit

Browser: contigC:2283448-2288178-

RNA-seq: read pairs 694, FPKM 5.5, percentile rank 18.5% (100% = highest expression)

Protein function

Annotation:REV3DNA polymerase zeta catalytic subunit
KEGG:K02350POLZ1 DNA polymerase zeta [EC:2.7.7.7]
EGGNOG:0PFY9REV3DNA polymerase
SGD closest match:S000006088REV3DNA polymerase zeta catalytic subunit
CGD closest match:CAL0000176488REV3DNA polymerase

Protein alignments

%idAln lengthE-value
MIA_02426_150.50%15920.0MIA_02426_1
A0A161HKH0_9ASCO44.41%14950.0DNA polymerase OS=Sugiyamaella lignohabitans GN=REV3 PE=3 SV=1
UniRef50_A0A161HKH044.41%14950.0DNA polymerase n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A161HKH0_9ASCO
A0A0J9X563_GEOCN53.14%10970.0DNA polymerase OS=Geotrichum candidum GN=BN980_GECA02s02595g PE=3 SV=1
A0A060T9Z7_BLAAD42.39%15640.0DNA polymerase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D19118g PE=3 SV=1
A0A1E3PNB5_9ASCO49.06%10150.0DNA polymerase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_8577 PE=3 SV=1
A0A1D8PKE9_CANAL37.21%15050.0DNA polymerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=REV3 PE=3 SV=1
Q6CB61_YARLI46.50%9870.0DNA polymerase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C21648g PE=3 SV=1
DPOZ_YEAST43.07%10030.0DNA polymerase zeta catalytic subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=REV3 PE=1 SV=1
A0A1E4TKE0_9ASCO40.44%7740.0DNA polymerase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_21996 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1073

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1554

Detailed signature matches

  1. Family IPR006172
    DNA-directed DNA polymerase, family B
    1. PR00106 (DNAPOLB)
    2. SM00486 (polmehr3)
  2. Domain IPR012337
    Ribonuclease H-like domain
    1. SSF53098 (Ribonucle...)
    2. G3DSA:3.30.42...
  3. Domain IPR006133
    DNA-directed DNA polymerase, family B, exonuclease domain
    1. PF03104 (DNA_pol_B_...)
  4. Domain IPR006134
    DNA-directed DNA polymerase, family B, multifunctional domain
    1. PF00136 (DNA_pol_B)
  5. Domain IPR023211
    DNA polymerase, palm domain
    1. G3DSA:3.90.16...
  6. Domain IPR025687
    C4-type zinc-finger of DNA polymerase delta
    1. PF14260 (zf-C4pol)
  7. SITE IPR017964
    DNA-directed DNA polymerase, family B, conserved site
    1. PS00116 (DNA_POLYME...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.30.34...
  3. SSF56672 (DNA/RNA p...)
  4. cd05534 (POLBc_zeta)
  5. cd05778 (DNA_polB_z...)

Residue annotation

  1. active site cd05534
  2. metal-binding site...

Protein sequence

>MCA_04178_1
MKKRYEVLEDCKFTCQINNIDHYQTFPTPLDRNVNSLSSPHQRLNSIPIIRIFGTTQAGQHAMVHVHGVYPYVYVEYKGS
LIPEDVMDYMKKLNTAITSAMIKAYRRDSTNPKNVFVANIVLCKGTPFYGYHVGWIPYLKIYLVNPAYMSKLSDLLRSGE
VMGFEMQPYEAHIPYLLQFLTDFNLKGCDSLNISSALFRSPLPVNDLEKESDDQVDSHTIFNQDNVSDHLVLPSTFTRMY
NGALEIDIDASSIENRHELHERNIHHNFENSMDMIKQTLRNSNEELVRFRNIKYVNSLKGIWADESKRRRIENTSSFKPK
ENNTQRTSPENVTIMWKRGEELSSELEERLETDKRQINGFKISFENFVKPTSYIHMAPTAFQTVEFMCTKLSISITRLKK
NNFEEATIAGFSNYLDENQNGIILDSHEPTSISEDEHGTDLDQEENQIDDLKDLENLSSFSDFSIAASPDSNKNYILDET
SELIPSKRPLNVSFTAPGKNSAASTKRFLVDSFANTSFTQPSFGNKSIDVSFFSTSQVGGSQERKIFKPSVVDKIKSAFP
TEDNVYIHKYQPPSVESVLSTFKKYNLPSIEYRQPFYSNKEDIPSEPTMFAGTEFNIKGNSVQDLDRFAFSESSGLGEIN
ILLDKTPLAMAKTFFFKTPPPSYKKVEEWCNKNEKNKQNGQKLLASQIRAPTQNNKYEFKYATQRRSKSRLATTASRYLS
FMSLELYVETREDFFPDPSNDPIKALFWAFQPEYQQMPYTKGCILLAETEEEKLKYQSMVTDFDVIVYESDELNLLNALI
DTVSFYDPDILCGYEINSSSWGYAIKRGRSHFEYDLCELLSRVNEKSFGKVGDRWGYTHTSAIQVTGRHVLNIWRILRND
LNLLSYSMENVAFHLLHYRIPHYKHQTLTEWFSSAEISVKSFTINYLHQRLKVLMDIIDTQEIIVRTSEEAKIIGIDFYS
VFYRGSQFKVESILTRIAKAENFMLPSPSKKQVGQQNAIECLPLILEPETRFYTSPVVVLDWQSLYPSVMIAYNYCYSTC
LGRVKSWRGRNKLGYTDIEIPKGLLTLLGKENLTVSPNGMIYVKPVIRQSLLGKMLTEFLETRVMVKDGMKSNKDDSAFQ
RLMNSRQLALKLIANVTYGYTSASFSGRMPCVEIADSIVQTGRETMENAIEHIRTNFAKWGAEVVYGDTDSLFIHFPGKT
KDEAFDLGQDIANEITSMNPQPMRLKFEKVYHPCILQTKKRYVGYMYEDKAQKEPVFNAKGIETVRRDGTPAQQKIEEKC
LKLLFDTCDLSQVKAYLQEQWAKIQQGKVSIQDFCFSKEVRLGTYKKRPPPGAMISANMVGKDPFSGPQYRERVPYVVIS
GNPGDRLIDRCVSPEYLIENQDVVHLDAEYYIMKNIIPPLERLFNLLGADIRQWYHDGPKVVNSLQFAGNHDNKAISSKL
DQHVLRNFIRTGGCKGCGEKLSKQEIETQIPVCFSCRSDPRYLVLKLISKSKLRERKLKELEEICYSCSRISLGSPIKCV
SYDCPIYYSRKKAVMYYNDSCNNDIPILNKALEW

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity

Cellular Component

None predicted.