MCA_04160_1

Protein

Length

1,178 amino acids

Gene name: SMC6B

Description: Structural maintenance of chromosomes protein 6

Browser: contigC:2232584-2236326-

RNA-seq: read pairs 480, FPKM 5.0, percentile rank 17.4% (100% = highest expression)

Protein function

Annotation:		SMC6B	Structural maintenance of chromosomes protein 6
EGGNOG:	0PGUP	SMC6	DNA repair protein
SGD closest match:	S000004375	SMC6	Structural maintenance of chromosomes protein 6
CGD closest match:	CAL0000185544	SMC6	DNA repair protein

Protein alignments

	%id	Aln length	E-value
MIA_02331_1	35.97%	1112	5e-172	MIA_02331_1
A0A0J9XHA9_GEOCN	34.62%	1089	5e-172	Similar to Saccharomyces cerevisiae YLR383W SMC6 Protein involved in structural maintenance of chromosomes OS=Geotrichum candidum GN=BN980_GECA17s02419g PE=4 SV=1
UniRef50_A0A0J9XHA9	34.62%	1089	1e-168	Similar to Saccharomyces cerevisiae YLR383W SMC6 Protein involved in structural maintenance of chromosomes n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHA9_GEOCN
Q5AGX1_CANAL	27.56%	791	2e-63	DNA repair protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SMC6 PE=4 SV=1
A0A1E3PEY4_9ASCO	39.51%	243	1e-43	p-loop containing nucleoside triphosphate hydrolase protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52937 PE=4 SV=1
SMC6_YEAST	45.83%	168	1e-40	Structural maintenance of chromosomes protein 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMC6 PE=1 SV=1
A0A161HGQ0_9ASCO	46.55%	174	2e-40	DNA repair protein SMC6 OS=Sugiyamaella lignohabitans GN=SMC6 PE=4 SV=1
A0A060T0P4_BLAAD	40.56%	180	7e-36	ARAD1C09900p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C09900g PE=4 SV=1
Q6C360_YARLI	32.02%	203	2e-14	YALI0F02365p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F02365g PE=4 SV=1
A0A1E4TDV6_9ASCO	26.11%	157	5e-08	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1669 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0032

Protein family membership

None predicted.

Domains and repeats

Domain
125 - 295
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
517 - 697
SMCs flexible hinge (IPR010935)
1,016 - 1,155
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 200 400 600 800 1000 1178

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  125 - 295
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  1,016 - 1,155
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR010935

SMCs flexible hinge
1. SSF75553 (Smc hinge...)
  
  517 - 697
  
  SUPERFAMILY
  SSF75553 (Smc hinge domain)

no IPR

Unintegrated signatures

Coil

500 - 548

COILS
Coil (Coil)

821 - 897

COILS
Coil (Coil)

902 - 936

COILS
Coil (Coil)

359 - 393

COILS
Coil (Coil)

306 - 337

COILS
Coil (Coil)

745 - 765

COILS
Coil (Coil)

408 - 456

COILS
Coil (Coil)
G3DSA:1.20.12...

305 - 465

GENE3D
G3DSA:1.20.120.570 (G3DSA:1.20.120.570)
G3DSA:1.20.5.340

817 - 936

GENE3D
G3DSA:1.20.5.340 (G3DSA:1.20.5.340)
G3DSA:1.20.58.60

499 - 816

GENE3D
G3DSA:1.20.58.60 (G3DSA:1.20.58.60)
G3DSA:3.40.50...

946 - 1,161

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

125 - 304

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PF13476 (AAA_23)

128 - 381

Pfam
PF13476 (AAA_23)
cd03276 (ABC_SMC6_euk)

126 - 282

CDD
cd03276 (ABC_SMC6_euk)

1,079 - 1,178

CDD
cd03276 (ABC_SMC6_euk)
mobidb-lite (disord...)

1 - 82

MobiDB Lite
mobidb-lite (disorder_prediction)

1,056 - 1,092

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Walker A/P-loop cd...

153G

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

154H

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

155N

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

156G

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

157S

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

158G

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

159K

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)

160S

Walker A/P-loop
153G, 154H, 155N, 156G, 157S, 158G, 159K, 160S
CDD
cd03276 (ABC_SMC6_euk)
ATP binding site c...

156G

ATP binding site
156G, 157S, 159K, 160S, 161A, 267Q
CDD
cd03276 (ABC_SMC6_euk)

157S

ATP binding site
156G, 157S, 159K, 160S, 161A, 267Q
CDD
cd03276 (ABC_SMC6_euk)

159K

ATP binding site
156G, 157S, 159K, 160S, 161A, 267Q
CDD
cd03276 (ABC_SMC6_euk)

160S

ATP binding site
156G, 157S, 159K, 160S, 161A, 267Q
CDD
cd03276 (ABC_SMC6_euk)

161A

ATP binding site
156G, 157S, 159K, 160S, 161A, 267Q
CDD
cd03276 (ABC_SMC6_euk)

267Q

ATP binding site
156G, 157S, 159K, 160S, 161A, 267Q
CDD
cd03276 (ABC_SMC6_euk)
Q-loop/lid cd03276

264I

Q-loop/lid
264I, 265L, 266Q, 267Q
CDD
cd03276 (ABC_SMC6_euk)

265L

Q-loop/lid
264I, 265L, 266Q, 267Q
CDD
cd03276 (ABC_SMC6_euk)

266Q

Q-loop/lid
264I, 265L, 266Q, 267Q
CDD
cd03276 (ABC_SMC6_euk)

267Q

Q-loop/lid
264I, 265L, 266Q, 267Q
CDD
cd03276 (ABC_SMC6_euk)
ABC transporter si...

1,091L

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,092S

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,093G

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,094G

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,095E

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,096K

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,097S

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,098F

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,099S

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)

1,100Q

ABC transporter signature motif
1,091L, 1,092S, 1,093G, 1,094G, 1,095E, 1,096K, 1,097S, 1,098F, 1,099S, 1,100Q
CDD
cd03276 (ABC_SMC6_euk)
Walker B cd03276

1,115I

Walker B
1,115I, 1,116R, 1,117G, 1,118L, 1,119D, 1,120E
CDD
cd03276 (ABC_SMC6_euk)

1,116R

Walker B
1,115I, 1,116R, 1,117G, 1,118L, 1,119D, 1,120E
CDD
cd03276 (ABC_SMC6_euk)

1,117G

Walker B
1,115I, 1,116R, 1,117G, 1,118L, 1,119D, 1,120E
CDD
cd03276 (ABC_SMC6_euk)

1,118L

Walker B
1,115I, 1,116R, 1,117G, 1,118L, 1,119D, 1,120E
CDD
cd03276 (ABC_SMC6_euk)

1,119D

Walker B
1,115I, 1,116R, 1,117G, 1,118L, 1,119D, 1,120E
CDD
cd03276 (ABC_SMC6_euk)

1,120E

Walker B
1,115I, 1,116R, 1,117G, 1,118L, 1,119D, 1,120E
CDD
cd03276 (ABC_SMC6_euk)
ATP binding site c...

1,119D

ATP binding site
1,119D, 1,120E, 1,154P
CDD
cd03276 (ABC_SMC6_euk)

1,120E

ATP binding site
1,119D, 1,120E, 1,154P
CDD
cd03276 (ABC_SMC6_euk)

1,154P

ATP binding site
1,119D, 1,120E, 1,154P
CDD
cd03276 (ABC_SMC6_euk)
D-loop cd03276

1,123V

D-loop
1,123V, 1,124F, 1,125M, 1,126D
CDD
cd03276 (ABC_SMC6_euk)

1,124F

D-loop
1,123V, 1,124F, 1,125M, 1,126D
CDD
cd03276 (ABC_SMC6_euk)

1,125M

D-loop
1,123V, 1,124F, 1,125M, 1,126D
CDD
cd03276 (ABC_SMC6_euk)

1,126D

D-loop
1,123V, 1,124F, 1,125M, 1,126D
CDD
cd03276 (ABC_SMC6_euk)
H-loop/switch regi...

1,150I

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

1,151F

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

1,152I

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

1,153T

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

1,154P

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

1,155N

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

1,156N

H-loop/switch region
1,150I, 1,151F, 1,152I, 1,153T, 1,154P, 1,155N, 1,156N
CDD
cd03276 (ABC_SMC6_euk)

Protein sequence

>MCA_04160_1
MAMEIQSQNYNKHALSPDVTDSSPRAKKARKSLSNLSETPDSETGSEDEQNTRQKDESIESETDESDIPVDEPDSSDEEL
KVTQVTSNFFTQTQKVIEDREKYIRERYEAIRNNQDAENSFDAGFITKLQLINFMCHKNLIIELGPKINFIVGHNGSGKS
AVLLALTICLGSSANKTDRAARLKDFIRSGQSRATIKVTLNNVGPSSYNHEIYGDEITIERTFDAKSSSYKIRNFQGKVI
SHFRKDLDDILDTFNIIVDNPLAILQQDAARSFLATSSNTERYEFFSKGINHEVWKKLSGMIDYNADQAHMAIETLKEEL
KKTKEELKMANAQYQAFDQFHEKAREIVQLEKTISWKKVELKEEDIEDLQQQIEEMEQKIQDYEQGMPKLIEAEKKVNDK
LEELASKKSISEEMKEEKDRQVEEAKQQCFESEQKLQRIKDTINELEQSTRRYQTSRQTVLDKIEEEERNIGGGYAEKRA
EYTKSKTILEQELQKVCGAIDEAITSKSATEEELENLKSQKIDIQKRINNLNQTINEHRHTIETIKKADSNFYEAFGPSM
ISILQQIESAGSRFKSKPIGPVGSFITLKAPQWAPIFNALYGKTLSSFIVNNAEDRQLLLSIFHNNNYKGSVITSQYDKF
NYEQNMPDRNKFTVAHDVLEFSNDHVKQVMIDYHRIEGTILFENRIQAEEVMKNRPSNVLNCIALISENQAVSIGSNVRG
ASGTTPLNGSYAALRMRTTGGASTLRACQEQLKESMREHETLLKEKIVKDRQYETVAKKADAMKKQMFSLNHRKSEITTE
LDKITDGLAQITDDQTLNDKLRNLQDQLSTIDETIKIYSSQHEEAQLEKVEYEQDVNDYKIILSKAEDEAEKEKSRIAEY
EEKEQTLRQELTSYRADSNDCLSAVNKKKDEKQKLLDEMELKKNELSELTNAATERAEERIHTSFTMEELNSQYIKLGNE
MKYIQNVTNSNTTFAQAVKRKAEAMKKYHDSREKLRVAKSVNEHLIVMQKERKKKYKSILDKTVSLVTETFANVLRERDF
EGSLHIDHDSREMIIKATPSGRGVSSNKRNDSRMMLPSSSEDNEGRDTRTLSGGEKSFSQIALLLAVWSAMTCRIRGLDE
FDVFMDEVNRKVSMKLMIDAVFSLDQGQTIFITPNNMADIKIDKRDVKIFKMADPERS

GO term prediction

Biological Process

GO:0051276 chromosome organization

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome

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Entry type

Status

Per-residue features