Protein
MCA_04116_1
Length
498 amino acids
Gene name: HER2
Description: Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
Browser: contigC:2098442-2100075+
RNA-seq: read pairs 1285, FPKM 31.8, percentile rank 54.4% (100% = highest expression)
Protein function
| Annotation: | HER2 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial | |
|---|---|---|---|
| KEGG: | K02433 | gatA | aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] |
| EGGNOG: | 0PGBS | HER2 | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) |
| SGD closest match: | S000004907 | HER2 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial |
| CGD closest match: | CAL0000174814 | HER2 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_02673_1 | 69.76% | 496 | 0.0 | MIA_02673_1 |
| A0A0J9X8R2_GEOCN | 57.94% | 485 | 0.0 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Geotrichum candidum GN=HER2 PE=3 SV=1 |
| UniRef50_A0A0J9X8R2 | 57.94% | 485 | 0.0 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9X8R2_GEOCN |
| A0A060T486_BLAAD | 55.49% | 483 | 8e-173 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Blastobotrys adeninivorans GN=HER2 PE=3 SV=1 |
| A0A1E3PMN1_9ASCO | 49.49% | 493 | 1e-149 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Nadsonia fulvescens var. elongata DSM 6958 GN=HER2 PE=3 SV=1 |
| A0A1E4TKC0_9ASCO | 48.25% | 487 | 2e-137 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Tortispora caseinolytica NRRL Y-17796 GN=HER2 PE=3 SV=1 |
| GATA_YARLI | 46.23% | 478 | 8e-130 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=HER2 PE=3 SV=1 |
| A0A167F5D0_9ASCO | 53.49% | 387 | 6e-129 | Glutamyl-tRNA(Gln) amidotransferase subunit HER2 OS=Sugiyamaella lignohabitans GN=HER2 PE=4 SV=1 |
| GATA_CANAL | 43.86% | 456 | 5e-108 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HER2 PE=3 SV=2 |
| GATA_YEAST | 43.54% | 441 | 2e-105 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HER2 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.7096
Predicted cleavage: 25
Protein family membership
- Glutamyl-tRNA(Gln) amidotransferase A subunit (IPR004412)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
350
400
450
498
Detailed signature matches
Protein sequence
>MCA_04116_1 MNQISSALIRQQGERYISNILSKNKIYNAVVSMRKSDDILKDAEAATTANKGALSGKYYILKDNFCTTELPTACGSKALE NYVSPYNSTTHELLLKAGGSYIGKANMDEFAMGSNNMTSGLYPYTVNPIFEDAATNPRTTGGSSGGSAAAVAAEMCDFAL GSDTGGSVRLPAAYCGVVGFKPTYGAISRHGLVAYAQSLDTVGICAKDVATTETVYKVLNEFDERDPTSLDTSIRKKIED YQNSIKKNGEKRKYKIGVIYENNLSDLDEHVRNAWVESLETLRSQGHEIVTVSVPSLKHALPTYFVVTPSEASSNLARYD GIRYGHRAETDRLGDILYASTRSEGFCEEVQRRIILGVFNLSSDFFGNHFQQAQKVRRKIQMEFNNIFSFPNFASINQSA ALSVGPKHETPVDVVISPASKTIAPTHEDIKKTTDAEGAVKSYVNDVLTVCPNIAGLPAISIPWGSGPKTIGMQVIGQFG DDNTVLDVARILEKSQLE
GO term prediction
Biological Process
GO:0006412 translation
Molecular Function
GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
Cellular Component
GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex