Protein

MCA_04033_1

Length
645 amino acids

Gene name: ERG12

Description: Mevalonate kinase

Browser: contigC:1814833-1816771-

RNA-seq: read pairs 1662, FPKM 31.8, percentile rank 54.3% (100% = highest expression)

Protein function

Annotation:ERG12Mevalonate kinase
KEGG:K00869E2.7.1.36 mevalonate kinase [EC:2.7.1.36]
EGGNOG:0PIG8ERG12mevalonate kinase
SGD closest match:S000004821ERG12Mevalonate kinase
CGD closest match:CAL0000186221ERG12Mevalonate kinase

Protein alignments

%idAln lengthE-value
MIA_00959_154.79%4802e-130MIA_00959_1
A0A0J9XG91_GEOCN51.91%3932e-97Mevalonate kinase OS=Geotrichum candidum GN=BN980_GECA15s03178g PE=3 SV=1
UniRef50_A0A0J9XG9151.91%3934e-94Mevalonate kinase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XG91_GEOCN
A0A167CPL2_9ASCO38.67%3315e-59Mevalonate kinase OS=Sugiyamaella lignohabitans GN=ERG12 PE=3 SV=1
A0A1D8PEL1_CANAL36.14%3325e-53Mevalonate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG12 PE=3 SV=1
Q6CEF6_YARLI33.76%3113e-48Mevalonate kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B16038g PE=3 SV=1
A0A1E3PMY2_9ASCO33.54%3168e-47Mevalonate kinase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45732 PE=3 SV=1
KIME_YEAST32.06%3402e-38Mevalonate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG12 PE=1 SV=1
A0A1E4TM26_9ASCO30.70%3298e-33Mevalonate kinase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_93700 PE=3 SV=1
A0A060TB02_BLAAD37.69%1995e-26Mevalonate kinase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D30602g PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1143

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 645

Detailed signature matches

  1. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  2. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  3. Domain IPR006204
    GHMP kinase N-terminal domain
    1. PF00288 (GHMP_kinas...)
  4. Domain IPR013750
    GHMP kinase, C-terminal domain
    1. PF08544 (GHMP_kinas...)
    2. SSF55060 (GHMP Kina...)
    3. G3DSA:3.30.70...
  5. SITE IPR006203
    GHMP kinase, ATP-binding, conserved site
    1. PS00627 (GHMP_KINAS...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Protein sequence

>MCA_04033_1
MTVSLPQFAVSAPGKVIIFGEHAAVYNKPAIAASISLRTYLLVTPNPDPSDRIIRIQFPDIDLNFQYPIDKLPWDLIPSS
ESHKMMQNPVTCCATEDSELNASSNQDIHNEDEEIPSNVSSPTSANSSFASEEDRPRSASIFSAPSTASTPHSSTTSFSL
DSHHTKNSSSHSKSQPSEEKINSDTNQQKQNNQNTPLPLSALVVDDKIVQALHSILVDLDNSFQYAALMAFFYLYLHICT
KDTPAHSFVSKSTLPVGAGLGSSATFSVCLSSAFLMLSEKLNFPASSEIAKQTEQVEKIINDKLSTLSIDNPALSDNASK
SKSVNDEYNYNNTKTSITCLGNPYHDLVNKWAYIGEKCLHGNPSGIDNTVACRGGAVLFQRPSTLIPMKKFPELELLLTN
TKQPRRTKDMVSRVGDLYNTFRQGTESILDAIEHVTQEAFLLLGAAEPTPVDLDVASSVTGAANSRCSTSDNSEVPKAKH
TRTALAPTVATIAESNKSLKRLLHLVRINHGLLVSLGVSHPKLEKIRSVGDELGIGETKLTGAGGGGCAITLLHAEDSDD
TSTTPDGKANQKRDIADRLAEFKGRLQSEKNGFEIFQTTLGGPGVGVTLISEDNGAGTNRGQMSVDEYLSLSREELESLN
WQYWG

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005524 ATP binding

Cellular Component

None predicted.