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Entry type
Status
Per-residue features
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Protein
MCA_04018_1
Length
586 amino acids
Gene name: MSL5
Description: Branchpoint-bridging protein
Browser: contigC:1781731-1783548+
RNA-seq: read pairs 2110, FPKM 44.4, percentile rank 62.7% (100% = highest expression)
Protein function
Annotation: | MSL5 | Branchpoint-bridging protein | |
---|---|---|---|
KEGG: | K13095 | SF1 | splicing factor 1 |
EGGNOG: | 0PFVG | BBP | Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity) |
SGD closest match: | S000004106 | MSL5 | Branchpoint-bridging protein |
CGD closest match: | CAL0000178990 | BBP | Branchpoint-bridging protein |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
A0A0J9X9S3_GEOCN | 58.17% | 404 | 2e-141 | Similar to Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex, which defines the first step in the splicing pathway OS=Geotrichum candidum GN=BN980_GECA07s00318g PE=4 SV=1 |
UniRef50_A0A0J9X9S3 | 58.17% | 404 | 3e-138 | Similar to Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex, which defines the first step in the splicing pathway n=5 Tax=saccharomyceta TaxID=716545 RepID=A0A0J9X9S3_GEOCN |
MIA_01820_1 | 61.18% | 322 | 1e-123 | MIA_01820_1 |
A0A1E3PT32_9ASCO | 58.93% | 336 | 1e-121 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45099 PE=4 SV=1 |
A0A060T4S9_BLAAD | 56.29% | 334 | 1e-110 | ARAD1C06094p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C06094g PE=4 SV=1 |
A0A167C7J2_9ASCO | 49.60% | 377 | 9e-103 | Msl5p OS=Sugiyamaella lignohabitans GN=MSL5 PE=4 SV=1 |
BBP_YARLI | 49.06% | 373 | 1e-98 | Branchpoint-bridging protein OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BBP PE=3 SV=1 |
A0A1E4TH52_9ASCO | 53.62% | 304 | 2e-91 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_19902 PE=4 SV=1 |
BBP_YEAST | 50.00% | 310 | 7e-87 | Branchpoint-bridging protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSL5 PE=1 SV=1 |
BBP_CANAL | 41.06% | 302 | 1e-61 | Branchpoint-bridging protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BBP PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3368
Predicted cleavage: 22
Protein family membership
None predicted.
Domains and repeats
-
Domain52 - 162
- Splicing factor 1, helix-hairpin domain (IPR032570)
282 - 405- Zinc finger, CCHC-type (IPR001878)
-
Domain161 - 285
- K Homology domain (IPR004087)
- K Homology domain, type 1 (IPR004088)
- K Homology domain (IPR004087)
1
100
200
300
400
500
586
Detailed signature matches
no IPR
Unintegrated signatures
-
PS50084 (KH_TYPE_1)182 - 252
-
cd02395 (SF1_like-KH)168 - 285
-
mobidb-lite (disord...)1 - 49106 - 129368 - 586325 - 348
Residue annotation
-
RNA binding site c...181IRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)182NRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)184IRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)185GRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)186LRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)188IRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)189GRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)190PRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)191RRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)192GRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)195LRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)206IRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)207ARNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)208VRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)209RRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)210GRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)213SRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)214VRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)215KRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)271RRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)274LRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)275RRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)277LRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)278ARNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)282GRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)283TRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)284LRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH)285RRNA binding site
181I, 182N, 184I, 185G, 186L, 188I, 189G, 190P, 191R, 192G, 195L, 206I, 207A, 208V, 209R, 210G, 213S, 214V, 215K, 271R, 274L, 275R, 277L, 278A, 282G, 283T, 284L, 285R
CDD
cd02395 (SF1_like-KH) -
G-X-X-G motif cd02...
Protein sequence
>MCA_04018_1 MSHRFDSKTGTNSVPLGKRRSDSHSVTASDMIFGNSSTSNDERLSHTDRRKKYRWNDASEENNILNAIKLTTQLSSPMTP EQLDAYALNFRIEEITIKLRFGDVVPKDRERSPSPTPQYDSQGKRTNTREVRYRTKLETERHKLIQRALKEIPNYKPPAD YKKPPKIQEKIFIPVDDFPGINFIGLLIGPRGHTLKKMESESGAKIAVRGKGSVKEGKGKADGPHQATMNENLHVLITAE EEHNLNKAIQLVNQVIETAASTPEEQNELKRGQLRELAALNGTLRNDDTNFCPICGDPGHRKIDCPSRKSYSNNIVCRFC GSAGHLSRDCKSRPSSGYGNSYRSNDTQNSMSNLAAEEEYHKLMQELGTDMPSSPSSQNRLRLTDSNHNKYNSNTNNQPR GGPAPWQQRNSNQGNNDSQWQNNHYENRGNYNNYNNRQGYDRGDRPNNYRNDRDRGDDYNNYSNNSNNYNNNNNYNNYNK NHHGYNNRYDNNDNYGRNQYNNNHHHQPPPPSRPQENIPPSHIPTQPAMHQLPAFSHVNKPAPPPGLSNIHPPGKGLPPP PPPPGKGRLPPPPPPGSARLPPPPPS
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0008270 zinc ion binding
Cellular Component
None predicted.