Protein

MCA_04003_1

Length
1,954 amino acids

Gene name: SEC7

Description: Protein transport protein SEC7

Browser: contigC:1749080-1754945-

RNA-seq: read pairs 5281, FPKM 33.4, percentile rank 55.6% (100% = highest expression)

Protein function

Annotation:SEC7Protein transport protein SEC7
KEGG:K18442ARFGEF brefeldin A-inhibited guanine nucleotide-exchange protein
EGGNOG:0PG3RSEC7guanyl-nucleotide exchange factor
SGD closest match:S000002577SEC7Protein transport protein SEC7
CGD closest match:CAL0000201823SEC7Arf family guanine nucleotide exchange factor

Protein alignments

%idAln lengthE-value
MIA_05846_168.65%20030.0MIA_05846_1
A0A0J9X8V4_GEOCN61.08%19860.0Similar to Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi and ER-to-Golgi transport OS=Geotrichum candidum GN=BN980_GECA04s06247g PE=4 SV=1
UniRef50_A0A0J9X7S556.31%18610.0Similar to Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi and ER-to-Golgi transport n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X7S5_GEOCN
A0A060T737_BLAAD53.35%18820.0ARAD1C25608p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C25608g PE=4 SV=1
A0A1E3PSN5_9ASCO51.57%18460.0Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_54895 PE=4 SV=1
Q6C820_YARLI45.14%19560.0YALI0D23463p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D23463g PE=4 SV=1
Q5ANF9_CANAL46.13%16040.0Arf family guanine nucleotide exchange factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SEC7 PE=4 SV=1
A0A167F5J2_9ASCO59.05%11600.0Arf family guanine nucleotide exchange factor SEC7 OS=Sugiyamaella lignohabitans GN=SEC7 PE=4 SV=1
SEC7_YEAST44.26%17080.0Protein transport protein SEC7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC7 PE=1 SV=2
A0A1E4TCD9_9ASCO40.85%18310.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_139370 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0209

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
1 200 400 600 800 1000 1200 1400 1600 1800 1954

Detailed signature matches

  1. Domain IPR011989
    Armadillo-like helical
    1. G3DSA:1.25.10.10
  2. Domain IPR032629
    Mon2, dimerisation and cyclophilin-binding domain
    1. PF16213 (DCB)
  3. Domain IPR032691
    Guanine nucleotide exchange factor, N-terminal
    1. PF12783 (Sec7_N)
  4. Domain IPR000904
    Sec7 domain
    1. SM00222 (sec7_5)
    2. SSF48425 (Sec7 domain)
    3. PS50190 (SEC7)
    4. PF01369 (Sec7)
  5. Domain IPR023394
    Sec7 domain, alpha orthogonal bundle
    1. G3DSA:1.10.10...
  6. Domain IPR016024
    Armadillo-type fold
    1. SSF48371 (ARM repeat)
  7. Domain IPR015403
    Sec7, C-terminal
    1. PF09324 (DUF1981)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.22...
  2. cd00171 (Sec7)
  3. mobidb-lite (disord...)

Residue annotation

  1. active site/putati...

Protein sequence

>MCA_04003_1
MTTDSTEAVVPVEPIPDTQPKSQPEDQKSSEPITDESFDDVSLDDAKPKSDVAEATEPQPKETEEQDPTPSAESREETST
PVPSIAVVTETPENVPSTPSNNNEDDDVANDNLTVSPTRTGRRSKRSPSLALSVSSITATGQHVISSDVFIKKALKAIKA
HKSTSKVPALDGSVTKALNIFDAGELPPPAVVFEPLRLVCSQTSNIELKVIALDCIGKLFTFSYLVDTSQEQPPAEAGIT
PPPKVPLLDRAIKTVCDCFQSESTDSKVELQIIKALMAAVLNDDLIAHGATLLRAIRQTYTIFVLSHSPTNQTIAQATLS
QMITVIFERLKSVLKSSNRSITNDSSTFSIPFDANAESSTNGSVPETPTTQSNGKLTLKQMENLGSSSDVERFKEEVPTT
DEDENDLFAKDAFLVFRTLCRLSEKTLEGDSLDVRSHSMRSKLLSLHLIYNVLNSHMSIFLSNEIIIHSNLKGSETFLLS
VKDYICSTLARNAASINPAVFEISSEIFFLIVSNLRSQFKKEIEVFFAEIYFPITEMKTSTYHQKQYLLSIVQRICNDPR
ALVEIYLNYDCDANSTLNIYEQLIDFLVKLAVTPVSLTSLQLQMYQESKGKSIAQYNLSLTPALAIMNFQNYTAAADNTQ
FPIEHALKMTALESFVAVLRSLLTWSQRGIAAVSASLNKSTGESDKTIEESSEANDSKSVLSVTTGSSTVVSDDPSQFQS
LKIKKTALQEAIRQFNIKPKKGIKNLLSSGLIESDSPKDIAQFLLTTEGLDKALLGEYLGEGDAENIAIMHAFVDLMDFS
NMRFVDALRKFLQAFRLPGESQKIDRYMLKFAERYTLGNPKVFANADTAYVLAYSVIMLNTDLHSPQVKNRMTLDDFYRN
NRGIDDNQDLPKEYLEEIYNEIRDNEIKLLSEQHAALLSSDGQQAATGFAANLSSVLATVGRDLQREAYMQASKEMSNKT
EQLFKSLISRDSKKTQESIFYIASHFEHVKPMFEVVWMSLLAGLSGPFQESDDPAVIKLCLEGFKLSIRIACLFEIDLAR
ISFVSALAQFTNLQNLSEMKQKNVDAIKQLLTTALSEGNLLKSSWKEVLTCISQLERFQLIAQGIEAGAIPDVTNARFAS
RKTSTDTVNSKATGGFFSRPRHLTQSSSNYSHNNMNGHELSYSPELAEELQSREISLNMDKIFTNSALLSGDAIVDFVRA
LTEVSAEEIQSSGQSEHPRTFSLQKMVDICYYNMERIRFEWSRLWAIMGKQFNIVGCHENTNVVFFALDSLRQLSIRFFD
LEELSHFKFQKEFLEPFAYVMGHNDNSAVKDMVLQCLQQMVLAKSEKIRSGWKTMFATFSISARQPYANVVNTTFDIVKR
IQEGNLEQVIAQDSFGNMVNCFSELAKNQRFQKPSLHSVEILKDTISKILKMKDDFDSQNTEVGSEFYTKYWFPVLFALH
DIIMNGEDLEVRSRALNYMFDALTTHGDSFDTEFWDTICRKLLFPTFVVLKSRSEMARFNTQDDMSVWLSTTMIQALRNM
IALLTHYFDTLGHMLDGFLELLTTCINQENDTVSRIGSSCLQQLIQENVEKFEDHHWSAVVDTIQHLFELTTASELFGDY
SDLDESLNDQGKDIANGTSENYKGHRPTASVASTTSTSGKEAALTGQEISGPKRQFSTDYNHTRQKRFRKTIVKCILQLL
MIDTVDDILQKQETIDADREPNTNGPPSAMVIRRQTKVSGTEIYEKIPVGHLLRILVLLRKSFIFAHRFNNNKELRTNLW
RLGFMKQLPNLLKQETLSAHVYISVLFRLFNDHEKLYPESATGNEKLDKPIVVEKYDIDYPSKIVEREAEAQKHGNKSDD
EQLPAEPKEYITITTQSELKAYLSKELMPMMAQLLAIYDRLEPNDARANQAWTPVVFCILEGLMALPRVEFSDVIEDLYP
GILGIMNRDMSPSLRIALQGTLKRVGQVIFKKGK

GO term prediction

Biological Process

GO:0032012 regulation of ARF protein signal transduction

Molecular Function

GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding

Cellular Component

None predicted.