Protein

MCA_03947_1

Length
1,830 amino acids

Browser: contigC:1588691-1594257-

RNA-seq: read pairs 623, FPKM 4.2, percentile rank 16.1% (100% = highest expression)

Protein function

KEGG:K14541DUR1 urea carboxylase / allophanate hydrolase [EC:6.3.4.6 3.5.1.54]
EGGNOG:0PHUIFG10913.1carboxylase
SGD closest match:S000000412DUR1,2Urea amidolyase
CGD closest match:CAL0000184290DUR1,2Bifunctional urea carboxylase/allophanate hydrolase

Protein alignments

%idAln lengthE-value
MIA_00086_183.17%18360.0MIA_00086_1
A0A161HFE0_9ASCO67.61%18340.0Bifunctional urea carboxylase/allophanate hydrolase OS=Sugiyamaella lignohabitans GN=DUR1,2 PE=4 SV=1
A0A1E3PSD7_9ASCO67.56%18370.0Urea amidolyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48988 PE=4 SV=1
Q6C6Q4_YARLI65.67%18350.0YALI0E07271p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E07271g PE=4 SV=1
A0A060TC69_BLAAD65.67%18320.0ARAD1D39732p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39732g PE=4 SV=1
A0A1E4T9N7_9ASCO63.02%18280.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_146769 PE=4 SV=1
UniRef50_A0A1E4SN0762.68%18460.0Urea carboxylase n=1 Tax=Candida tanzawaensis NRRL Y-17324 TaxID=984487 RepID=A0A1E4SN07_9ASCO
A0A1D8PDC6_CANAL62.21%18420.0Bifunctional urea carboxylase/allophanate hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DUR1,2 PE=4 SV=1
DUR1_YEAST60.55%18530.0Urea amidolyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUR1,2 PE=1 SV=2
A0A0J9X8S2_GEOCN42.33%4372e-109Similar to Saccharomyces cerevisiae YBR208C DUR1,2 Urea amidolyase OS=Geotrichum candidum GN=BN980_GECA05s04498g PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0190

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 200 400 600 800 1000 1200 1400 1600 1830

Detailed signature matches

  1. Family IPR014084
    Urea carboxylase
    1. TIGR02712
  2. Domain IPR023631
    Amidase signature domain
    1. SSF75304 (Amidase s...)
    2. G3DSA:3.90.13...
    3. PF01425 (Amidase)
  3. Domain IPR014085
    Allophanate hydrolase
    1. TIGR02713
  4. Domain IPR016185
    Pre-ATP-grasp domain
    1. SSF52440 (PreATP-gr...)
  5. Domain IPR011764
    Biotin carboxylation domain
    1. PS50979 (BC)
  6. Domain IPR005481
    Biotin carboxylase-like, N-terminal domain
    1. PF00289 (Biotin_carb_N)
  7. Domain IPR011761
    ATP-grasp fold
    1. PS50975 (ATP_GRASP)
  8. Domain IPR005479
    Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
    1. PF02786 (CPSase_L_D2)
    2. PS00867 (CPSASE_2)
    3. PS00866 (CPSASE_1)
  9. Domain IPR013815
    ATP-grasp fold, subdomain 1
    1. G3DSA:3.30.14...
  10. Domain IPR011054
    Rudiment single hybrid motif
    1. SSF51246 (Rudiment ...)
  11. Domain IPR005482
    Biotin carboxylase, C-terminal
    1. SM00878 (Biotin_car...)
    2. PF02785 (Biotin_carb_C)
  12. Domain IPR003778
    Carboxyltransferase domain, subdomain A and B
    1. PF02626 (CT_A_B)
    2. TIGR00724
    3. SM00797 (ahs2)
  13. Domain IPR029000
    Cyclophilin-like domain
    1. SSF50891 (Cyclophil...)
    2. G3DSA:2.40.10...
  14. Domain IPR024946
    Arginine repressor C-terminal-like domain
    1. G3DSA:3.30.13...
  15. Domain IPR003833
    Carboxyltransferase domain, subdomain C and D
    1. SM00796 (ahs1)
    2. PF02682 (CT_C_D)
  16. Domain IPR011053
    Single hybrid motif
    1. SSF51230 (Single hy...)
  17. Domain IPR000089
    Biotin/lipoyl attachment
    1. PS50968 (BIOTINYL_L...)
    2. PF00364 (Biotin_lipoyl)
  18. SITE IPR001882
    Biotin-binding site
    1. PS00188 (BIOTIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:2.40.50...
  3. G3DSA:3.10.49...
  4. G3DSA:3.30.47...
  5. G3DSA:3.40.50.20
  6. SSF160467 (PH0987 N...)
  7. SSF56059 (Glutathio...)
  8. cd06850 (biotinyl_d...)

Residue annotation

  1. carboxyltransferas...
  2. biotinylation site...

Protein sequence

>MCA_03947_1
MSVSTIGWTISQWTDFTTKSDPSKVLEALTSLVSSFKKDDPAWITVATPDQIVSQWKSLQTQGEEAKKLPLYGVPYAVKD
NIDALDFPTTAACPAFKYDPKEDATVVSLLRKAGAIVVGKTNLDQFATGLVGTRSPYGKTPCVFSDKHVSGGSSAGSASV
VGRGLVPLALGTDTAGSGRVPAALNNLIGLKPTRGSLSCKGVVPACRSLDCPSIFTLNLQDAQLAYSIVAKFDEADGYSR
PLPNKLLTTFGKSPVFAVPDTPLFFGEEENPKLFAKAIETLKSIGVQIVEKDFSVLYKLANLLYEGPWVGERYAAIREFV
TSKKDEMDPVVYGIVKKAENFSAADCFDFEYARMDILRAIQKEFDQFDGLVVPTCPLNPTFDDIAAEPVLVNSRQGTYTN
FVNLADLSALAVPAGFRPDGLTTGITFISKKFNDYALLDIASKYLRATPSRPIGGLEIAVENGDLLHPSIPETSPALIPL
VVVGGHLSGMALNWQLQKVDAKLAKKTTTSPNYRLYALPNTTPAKPGLRRILTSDAPLVGEKIIVEVWNVPAENFGTFIS
MVPHPLGIGSVELADGSWVKGFICEQAGFHGAEDITSYGGWRAYMASKAKPEDRPFDTVLVANHGEIAVRIIKTLKKLGI
KAIAVFSEPDRYTQHVLDADDAVSLEGTTAAETYLNVQKIINAALKTGAQAIIPGYGFLSENADFAEACEDNGIIFVGPS
PESIRSLGLKHSAREIAEKAGVPMVPGSGLLDTVEEAIAAAEKVKYPVMIKSTAGGGGIGLQCVRDPKDLPKAFETVKHQ
GLSYFNDSGVFIERNVENARHVEVQVFGDGRGGAIALGERDCSLQRRHQKIVEETPAPRLSDSTRAAMRKAAQSLVSTMK
YKCAGTVEFIYDEKNEEFYFLEVNARLQVEHTITEEVTGLDLVEWMLYIAADRPPSFDKEIVPKGAAIEVRIYAENPVKD
FLPSPGQITDVHFPEDARVDTWVVKGSTISPEYDPTIAKMIVWGKDRDEAIKKMVKALDETVIYGPVTNIDYLRSIVGSE
MFSKAEVSTKVLDSYTYTPPALEITAPGSYTTVQDYPGRVQLWRIGVPPSGPMDSYAFRIANRIVGNDSKAPAIECTLIG
PSLIFHCDSVFALTGGLSPATLDGEPVEFWKPISAKAGSKLVVGKLSSGCRSYLAIRGGIDVPEYLNSRSTFALGTMGGF
NGRVLKFGDVLFLGNPKVSSCTIPAPIAEPIEVPKSLIPPVLSTRSTGSTTWNVGVTVGPHGSPDFFKAEYIETFFNSEW
KVHYNSNRFGVRLIGPKPQWARPDGGEAGLHPSNAHDYVYSLGAVNFTGDEPVVLTCDGPSLGGFVCAAVVVEAEMWKIG
QVKPGDMIKFVPITFDEAIELKNWQDKVIDAEGGFLDESPLEIVTKAATRGDEIAKSDPVLYHKEATSSSPKVVYRQAGD
RYILVEYGENIMDLNLSYRVFKLTEAVFGHNTKGVVEMSPGVRSVLIEFTGKKTTQKELLDTLIGYESKLQQTDNWQVPS
RVIRLPLAFEDSKTLGAVERYKETIRSTAPWLPNNVDFIKEVNGLKDRNEVRDMLYVARFLVLGLGDVFLGAPCAVPLDP
RHRFLGTKYNPSRTYTPNGTVGIGGMYMCIYTMESPGGYQLVGRTIPIWDKLTLGQQDRPWLLSQFDVIEYFSVTEEELD
EYCAQVENGQYHISIEDSVFDHGEYVKWIENNKESINAFAARQLEGNEEISRLIQISNAELEAAQSKDVEEDTTQYSDNA
EMVYAEVTGRFWKNMVNVGDKVEKGQGILIVEAMKTEMVVPASASGTVVKIVHKNGDIVESGDLVAVIEP

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0004075 biotin carboxylase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding

Cellular Component

None predicted.