Protein

MCA_03872_1

Length
489 amino acids

Gene name: ISC1

Description: Inositol phosphosphingolipids phospholipase C

Browser: contigC:1363218-1364763-

RNA-seq: read pairs 723, FPKM 18.2, percentile rank 38.9% (100% = highest expression)

Protein function

Annotation:ISC1Inositol phosphosphingolipids phospholipase C
KEGG:K12351SMPD2 sphingomyelin phosphodiesterase 2 [EC:3.1.4.12]
EGGNOG:0PMCNISC1phospholipase C
SGD closest match:S000000821ISC1Inositol phosphosphingolipids phospholipase C
CGD closest match:CAL0000175369ISC1Inositol phosphosphingolipid phospholipase

Protein alignments

%idAln lengthE-value
MIA_02068_164.47%5150.0MIA_02068_1
A0A167FEM2_9ASCO53.66%4643e-159Inositol phosphosphingolipid phospholipase OS=Sugiyamaella lignohabitans GN=ISC1 PE=4 SV=1
A0A0J9XDQ1_GEOCN60.80%3523e-144Similar to Saccharomyces cerevisiae YER019W ISC1 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide OS=Geotrichum candidum GN=BN980_GECA11s00494g PE=4 SV=1
UniRef50_A0A0J9XDQ160.80%3525e-141Similar to Saccharomyces cerevisiae YER019W ISC1 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XDQ1_GEOCN
A0A1E3PNA9_9ASCO58.58%3095e-123DNase I-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_23006 PE=4 SV=1
Q6C8M5_YARLI57.05%3057e-121YALI0D18458p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D18458g PE=4 SV=1
A0A060T926_BLAAD45.91%4641e-116ARAD1C34628p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C34628g PE=4 SV=1
A0A1E4TBC1_9ASCO42.52%4681e-102Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_27014 PE=4 SV=1
ISC1_YEAST40.00%4801e-99Inositol phosphosphingolipids phospholipase C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISC1 PE=1 SV=1
A0A1D8PT33_CANAL39.30%4867e-93Inositol phosphosphingolipid phospholipase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ISC1 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0502

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 450 489

Detailed signature matches

  1. Domain IPR005135
    Endonuclease/exonuclease/phosphatase
    1. SSF56219 (DNase I-like)
    2. PF03372 (Exo_endo_phos)
    3. G3DSA:3.60.10.10
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)

Protein sequence

>MCA_03872_1
MDSTHGEIKPSASTSGGNHVTARILSLNCWGLKYVSKFRPQRLRGIAEQLTRDGHLYDIVALQEIWVEEDYYLLKTMTCS
QFPYHKYFYSGILSGPGLLVLSKWPIESAYMLRYPLNGRPSAFYRGDWFVGKSAASVVIKPPGVNTRPIELLSTHLHAPY
GPGDAAYTCHRTGQAWELARLAKRASDLGHAVFVLGDLNSIPGSLSHRLFQHVALLRDTWEDIHGEYEGGPEAIALLSPE
DQILVAGTTCDSRLNTWRADRRPDEAKRLDYIFYDPKHATPVSCKVSFTEKIPGIGSYSDHFAVEASVIIKPINKVNTNN
DAPLIQPLVTDSKKEGYAHNSPAPSSENSSYFENPYNKQVMADISVDQPNKPKDLSLAQIKPDKEELKLLYTDILELIED
YKPTSIKQAKLRNAHFIASVVVLIGLLIAVWWGAAHDRAYVGFIFLLLTIVISVTGLLDGLIGFLFGRNEWRALLEFQSE
VELALDFLD

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.