Protein

MCA_03813_1

Length
945 amino acids

Gene name: LAS21

Description: GPI ethanolamine phosphate transferase 2

Browser: contigC:1155794-1158632+

RNA-seq: read pairs 2413, FPKM 31.5, percentile rank 54.0% (100% = highest expression)

Protein function

Annotation:LAS21GPI ethanolamine phosphate transferase 2
KEGG:K05310GPI7 ethanolaminephosphotransferase [EC:2.7.-.-]
EGGNOG:0PHUDLAS21Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose
SGD closest match:S000003598LAS21GPI ethanolamine phosphate transferase 2
CGD closest match:CAL0000200443GPI7GPI ethanolamine phosphate transferase 2

Protein alignments

%idAln lengthE-value
MIA_05269_165.29%9450.0MIA_05269_1
A0A0J9XA45_GEOCN56.00%9160.0Similar to Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure OS=Geotrichum candidum GN=BN980_GECA06s04003g PE=4 SV=1
A0A167EB56_9ASCO48.65%9620.0Las21p OS=Sugiyamaella lignohabitans GN=LAS21 PE=4 SV=1
UniRef50_A0A167EB5648.65%9620.0Las21p n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167EB56_9ASCO
A0A060T0D6_BLAAD49.05%9460.0ARAD1C06490p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C06490g PE=4 SV=1
A0A1E3PHC3_9ASCO46.96%9540.0Alkaline phosphatase-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_71169 PE=4 SV=1
GPI7_YARLI41.81%9400.0GPI ethanolamine phosphate transferase 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=LAS21 PE=3 SV=1
GPI7_CANAL39.01%9463e-176GPI ethanolamine phosphate transferase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GPI7 PE=3 SV=3
A0A1E4TM24_9ASCO40.22%9251e-175Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1398 PE=4 SV=1
GPI7_YEAST33.22%9183e-117GPI ethanolamine phosphate transferase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LAS21 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5902
Predicted cleavage: 16

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 945

Detailed signature matches

  1. Family IPR002591
    Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
    1. PF01663 (Phosphodiest)
  2. Domain IPR017849
    Alkaline phosphatase-like, alpha/beta/alpha
    1. G3DSA:3.40.72...
  3. Domain IPR017850
    Alkaline-phosphatase-like, core domain
    1. SSF53649 (Alkaline ...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. CYTOPLASMIC_D... (C...)
  2. NON_CYTOPLASM... (N...)
  3. TMhelix
  4. TRANSMEMBRANE (Tran...)
  5. cd16024 (GPI_EPT_2)

Residue annotation

  1. putative active si...
  2. metal binding site...
  3. putative substrate...

Protein sequence

>MCA_03813_1
MSLLLRWIGIFIVLILQLTGLYFFGLGFFPQKIVLPGQATFLPDNDPSNVPDAAYNKFIFMVIDAFRSDFAFSTSSSMPF
IHQCIRDRKALGYTAFSTPPTVTLPRLKGLTSGGTPNFLDAILNIADEDTSEQSNKHDSWVRQLKSQGKKIHMFGDDTWM
KLFPDLFDKVDGTASFFVSDFTEVDNNVTRHLDYELSHQEEWDTLILHYLGLDHIGHKGGPESPFMAGKQKEMNGIIERI
YKEMSDDTLLLVVGDHGMNEAGNHGGSSSGETSAATIFFSKRPNLLLSQDSENPQAPLPLSNDFHYYRKISQSDIVPTLA
ALLKFPIPMNSLGIVLKDVVKAMWENKEDQHKVLKQNVYQMNNIIDSSYPGFTTLDADSTMFCESQIDFDDLPEIEKLKC
MWWKLQQEDNKELDEELAYSYLKSVQSMLSQASSNYNVNEMVTGLGFSVLSLLISAGCSWKLLRSVPLIRFILFMITLLY
TFSMFGSSLVEEEHHLWYWGITGWVSWLYILTTRKSFSDGFDWVLSLIMVRIIRSWNQTGQKYAGGPDIASYLARPESAG
MLWFLIMLYYGSLFERLWKGTFQSVNQMAGFVFSFLTIASSIAFKVTMACQSGETVPNLLQKLVAYEQMENANSDMSTLI
TLARLSFFIIAMGTLYELSNIVLADPQLMFLDQSGSTNGKGKSNKNKHITNMCVFLELLLVMQSKTSNIPLFIFFNMLKV
YLVKATNKSFVYRATNDLDQADDALKKERFGVRVIAILSITILILQHMSFFAMGNSNSLASLDLSNAYNGVSSYNIILVG
ILTFIGNFAGPLYWSATGLSILLEDDIRSEILRAHLLRSSEQLKEIMTQRTKEEKRGEVMVINRRKFEESVSMIGQNVVT
LRIVISQVFFSGVLVGILGACIALKDHLFIWTVFSPKLLYSIAWVILQHVTVDVIICTVLSFLRG

GO term prediction

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.